Purinergic P2X3 Receptors

A purinergic P2X neurotransmitter receptor involved in sensory signaling of TASTE PERCEPTION, chemoreception, visceral distension, and NEUROPATHIC PAIN. The receptor comprises three P2X3 subunits. The P2X3 subunits are also associated with P2X2 RECEPTOR subunits in a heterotrimeric receptor variant.

Also Known As:

Networked: 211 relevant articles (15 outcomes, 46 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liang, Shangdong: 24 articles (12/2020 - 05/2008)
2.	Li, Guilin: 23 articles (09/2021 - 12/2009)
3.	Liu, Shuangmei: 22 articles (12/2020 - 12/2009)
4.	Gao, Yun: 22 articles (10/2020 - 05/2008)
5.	Xu, Changshui: 16 articles (10/2020 - 05/2008)
6.	Wu, Bing: 13 articles (11/2019 - 05/2014)
7.	Nistri, Andrea: 13 articles (04/2019 - 06/2006)
8.	Zou, Lifang: 12 articles (12/2020 - 03/2016)
9.	Zhang, Chunping: 12 articles (11/2019 - 05/2008)
10.	Xu, Hong: 12 articles (09/2019 - 01/2012)

Related Diseases

1.	Chronic Cough 10/01/2023 - "Focusing on four P2X3 receptor antagonists with proven efficacy in clinical studies, we analyzed the characteristics and disadvantages of each drug by comparing their clinical results of them and theoretically explained the common side effects of these drugs, as well as their potential for treating refractory chronic cough. " 10/01/2023 - "KEY MESSAGE: There were plenty of studies about P2X3 receptor antagonists in the past, and in recent years this series of drugs are effective in refractory chronic cough. " 09/09/2023 - "Safety and efficacy of P2X3 receptor antagonist for the treatment of refractory or unexplained chronic cough: A systematic review and meta-analysis of 11 randomized controlled trials." 09/09/2023 - "We conducted this systematic review and meta-analysis to determine the long-term safety and efficacy of P2X3 receptor antagonist drugs in chronic cough. " 10/01/2023 - "Recently, several studies have identified P2X3 receptor antagonists for the treatment of refractory chronic cough, and this paper reviews the background, mechanism of action, evidence-based proof and application prospects of this class of drugs. "
2.	Hyperalgesia 01/01/2017 - "Therefore, the inhibition of the P2X3 receptor in rat DRG neurons relieved gp120-induced mechanical hyperalgesia." 04/01/2013 - "In conclusion, this study suggests that neuronal P2X3 receptor activation and the consequent PKCɛ translocation increase the susceptibility of nociceptor to inflammatory mediators allowing the development of inflammatory hyperalgesia." 09/01/2021 - "The results indicated that the expression of P2X3 receptor was significantly increased in the DRGs of CCI rats and that mechanical allodynia and thermal hyperalgesia were also enhanced in CCI rats. " 01/01/2018 - "Variable transcriptional responsiveness of the P2X3 receptor gene during CFA-induced inflammatory hyperalgesia." 12/01/2017 - "In contrast, the expression of the P2X3 receptor, a marker for non-peptidergic nerve fibers, was not only significantly reduced but could also be correlated with behavioral hyperalgesia. "
3.	Neuralgia (Stump Neuralgia) 04/01/2019 - "The results of the present study provided the first evidence regarding the regulation of the expression of the P2X1-6 receptor in sensory neurons being directly associated with chronic nerve injury in rats and also suggest that compared with the P2X3 receptor, the P2X2/3 heteromeric receptor is not the major receptor involved in peripheral neuropathic pain sensation. " 01/01/2017 - "In this study, we aimed to explore the role of the P2X3 receptor in gp120-induced neuropathic pain. " 05/01/2023 - "In turn, P2X3 receptor-expressed TG neurons are enhanced via mGluR5 signaling, resulting in orofacial neuropathic pain." 04/26/2021 - "P2X3 receptor upregulation in trigeminal ganglion neurons through TNFα production in macrophages contributes to trigeminal neuropathic pain in rats." 10/01/2017 - "The P2X3 receptor in the dorsal root ganglia (DRG) is associated with the transmission of neuropathic pain. "
4.	Chronic Pain 01/01/2018 - "The P2X3 receptor is primarily expressed in the peripheral sensory nerves, and therefore, antagonists of this receptor may be useful for the treatment of chronic pain. " 01/01/2017 - "Blocking membrane currents evoked by the activation of purinergic P2X3 receptors localized on nociceptive neurons represents a promising strategy for the development of agents useful for the treatment of chronic pain conditions. " 11/14/2015 - "This novel mechanism of receptor control might be a target for future studies aiming at decreasing dysregulated P2X3 receptor activity in chronic pain." 01/01/2019 - "Accumulated evidence suggests that purinergic P2X3 receptors (P2X3Rs) in dorsal root ganglion neurons play a major role in mediating chronic pain associated with nerve injury. " 06/01/2001 - "The ability to specifically downregulate the P2X3 receptor by ASO treatment will allow investigation of the biologic role of this receptor in neuronal tissues and eventually in in vivo models of chronic pain."
5.	Hypersensitivity (Allergy) 01/01/2020 - "The behavioral studies, histopathology of colon, electrophysiology, immunofluorescence histochemistry, and real-time polymerase chain reaction assays were used to observe the role of P2X3 receptor in the colon and related DRG in relieving visceral hypersensitivity by EA. " 01/01/2020 - "To reveal the neurobiological mechanism that P2X3 receptor of colonic primary sensory neurons in the dorsal root ganglia of the lumbosacral segment is involved in the alleviation of visceral hypersensitivity by EA in an IBS rat model. " 03/25/2013 - "Immunohistochemistry was used to detect P2X2 and P2X3 receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. " 07/01/2006 - "Thus, it is suggested that the activation of the P2X3 receptor is involved in the phosphorylation of ERK in DRG neurons and the mechanical hypersensitivity of the inflamed knee joint." 03/25/2013 - "After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X2 and P2X3 receptor expression decreased in rats with visceral hypersensitivity. "

Related Drugs and Biologics

1.	A-317491
2.	Gefapixant
3.	Narcotics (Narcotic Analgesics)
4.	Hesperidin
5.	2',3'-O-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate
6.	Interleukin-1beta (Interleukin 1 beta)
7.	Epinephrine (Adrenaline)
8.	Octoxynol (Triton X 100)
9.	Biomarkers (Surrogate Marker)
10.	Enzymes

Related Therapies and Procedures

1.	Electroacupuncture
2.	Therapeutics
3.	Analgesia
4.	Spinal Injections
5.	Ligation