Purinergic P2X2 Receptors

A purinergic P2X neurotransmitter receptor involved in sensory signaling of TASTE PERCEPTION, chemoreception, visceral distension and NEUROPATHIC PAIN. The receptor comprises three P2X2 subunits. The P2X2 subunits also have been found associated with P2X3 RECEPTOR subunits in a heterotrimeric receptor variant.

Also Known As:

Receptors, Purinergic P2X2; P2X2 Purinoceptor; P2X2 Purinoceptors; P2X2 Receptor; Purinergic Receptor P2X, Ligand-Gated Ion Channel, 2; P2X2 Receptors, Purinergic; Purinoceptor, P2X2; Purinoceptors, P2X2; Receptor, P2X2

Networked: 18 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Ligand-Gated Ion Channels: 221
        Purinergic P2X Receptors: 62
        Purinergic P2X2 Receptors: 18
        human P2RX2 protein
        mouse P2rx2 protein
        rat P2rx2 protein
  - Membrane Proteins: 10078

Experts

1.	Castelucci, Patricia: 3 articles (09/2015 - 08/2011)
2.	Liu, Zeng-Xu: 2 articles (10/2020 - 01/2019)
3.	Palombit, Kelly: 2 articles (09/2015 - 08/2011)
4.	Mizuno, Márcia Sanae: 2 articles (10/2014 - 08/2011)
5.	Burnstock, Geoffrey: 2 articles (03/2004 - 12/2003)
6.	Xiang, Zhenghua: 2 articles (03/2004 - 12/2003)
7.	Gourine, Alexander V: 2 articles (12/2003 - 10/2003)
8.	Spyer, K Michael: 2 articles (12/2003 - 10/2003)
9.	Ishihara, Hiroyuki: 1 article (01/2022)
10.	Kamei, Tadashi: 1 article (01/2022)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 10/01/2020 - "The purpose of this study was to determine the effect of microencapsulated olfactory ensheathing cells (MC-OECs) transplantation on neuropathic pain (NPP) caused by sciatic nerve injury in rats, and its relationship with the expression levels of P2X2 receptor (P2X2R) in the L4-5 spinal cord segment. " 10/01/2020 - "Transplantation of microencapsulated olfactory ensheathing cells inhibits the P2X2 receptor over-expressionmediated neuropathic pain in the L4-5 spinal cord segment." 01/01/2019 - "In the present study, We thus investigated in the spinal cord dorsal horn whether 1,8-cineole inhibits the expression of P2X2 receptor-mediated neuropathic pain. " 01/01/2019 - "Effects of 1,8-cineole on neuropathic pain mediated by P2X2 receptor in the spinal cord dorsal horn."
2.	Hyperesthesia 06/01/2015 - "This study provides a basis for the study of P2X2 receptor in ICC in bladder hyperesthesia of OAB patients. "
3.	Body Weight (Weight, Body) 11/24/2010 - "The aim of this study was to study the cellular localization and to identify the chemical phenotypes of ionotropic P2X2 receptor (P2X2R)-containing neurons in the rat mediobasal hypothalamus by immunohistochemistry using three different P2X2R antisera, with special reference to neurons that influence food intake and body weight. "
4.	Hypoxia (Hypoxemia) 01/01/2006 - "In normal preparations, CSN activity evoked by hypoxia in vitro was 65% inhibited in the presence of specific P2X2 receptor antagonists. " 12/01/2004 - "Furthermore, our data show that acute hypoxia selectively modulates the P2X2 receptor and that the response of P2X2 receptor subunits to hypoxia is mediated through the mitochondrial production of ROS." 12/10/2003 - "Mice deficient in P2X2 receptor subunit showed a markedly attenuated ventilatory response to hypoxia, whereas the response to hypoxia in P2X3-deficient mice was comparable with that seen in wild-type controls. " 01/01/2006 - "The present experiments examined the effects of CH (9-16 days at 380 Torr) on the expression of P2X2 purinoceptors in carotid body and chemoafferent neurons, as well as the effectiveness of P2X2 receptor blocking drugs on CSN activity evoked by hypoxia. " 12/10/2003 - "Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia."
5.	Ganglion Cysts (Ganglion) 09/01/2006 - "Age-associated changes in distribution of the P2X2 receptor in the major pelvic ganglion of the male rat." 03/01/2004 - "Approximately 60%, 70% and 50% of the ganglion cells in the myenteric plexus of the gastric corpus, ileum and distal colon, and 56% and 45% in the submucosal plexus of the ileum and distal colon, respectively, showed positive immunoreactivity to the P2X2 receptor. " 09/01/2006 - "P2X purinoceptors constitute a group of ligand-gated ion channels one of which, the P2X2 receptor has previously been described in neurons within autonomic ganglia, including the major pelvic ganglion (MPG). "

Related Drugs and Biologics

1.	Immune Sera (Antisera)
2.	Eucalyptol
3.	Purinergic P2X2 Receptors
4.	Ion Channels (Ion Channel)
5.	Adenosine Triphosphate (ATP)
6.	Purinergic P2X Receptors
7.	Ligand-Gated Ion Channels
8.	Tretinoin (Retinoic Acid)
9.	Messenger RNA (mRNA)
10.	Purinergic Receptors (Receptors, Purine)

Related Therapies and Procedures

1.	Transplantation