|1.||Gachet, C: 4 articles (06/2003 - 07/2001)|
|2.||Reiser, Georg: 3 articles (12/2015 - 01/2008)|
|3.||Gachet, Christian: 3 articles (11/2015 - 07/2003)|
|4.||Burnstock, Geoffrey: 3 articles (06/2005 - 01/2002)|
|5.||Shen, Hong: 2 articles (02/2015 - 06/2014)|
|6.||Han, Ho-Jae: 2 articles (04/2014 - 01/2014)|
|7.||Lee, Jang-Hern: 2 articles (04/2014 - 01/2014)|
|8.||Roh, Dae-Hyun: 2 articles (04/2014 - 01/2014)|
|9.||Kwon, Soon-Gu: 2 articles (04/2014 - 01/2014)|
|10.||Yoon, Seo-Yeon: 2 articles (04/2014 - 01/2014)|
06/01/2014 - "Blockade of the P2Y1 receptor is important to the treatment of thrombosis with potentially improved safety margins compared with P2Y12 receptor antagonists. "
12/01/2001 - "Studies in P2Y1-knockout mice and experimental thrombosis models using selective P2Y1 antagonists have shown that the P2Y1 receptor, like the P2Y12 receptor, is a potential target for new antithrombotic drugs."
07/01/2001 - "Studies in P2Y1 knock-out mice and experimental thrombosis models using selective P2Y1 antagonists have shown that the P2Y1 receptor, like the P2Y12 receptor, is a potential target for new antithrombotic drugs."
11/01/2015 - "In this review, we focus on the specific role of the 3 platelet P2 receptors P2Y1, P2Y12, and P2X1 in hemostasis and arterial thrombosis. "
11/01/2014 - "Antithrombotic activity of a new P2Y1 receptor antagonist, substance Sbt-119, on experimental models of thromboses in rats."
|2.||Brain Injuries (Brain Injury)
12/01/2015 - "Moreover, antagonists of the P2Y1 receptor, one of the most abundant P2Y receptor subtypes in brain tissue, decreased neuronal loss and improved spatial memory in rats after traumatic brain injury (TBI). "
01/01/2013 - "Finally, the most promising therapeutic candidate from our in vitro screen (MRS 2179, a P2Y1 receptor antagonist) also improves histological and cognitive outcomes in a preclinical model of traumatic brain injury. "
|3.||Astrocytoma (Pilocytic Astrocytoma)
11/01/1996 - "A3P5PS, A3P5P, and adenosine-2',5'-diphosphate also were competitive antagonists in studies with the cloned human P2Y1 receptor stably expressed in 1321N1 human astrocytoma cells. "
05/01/2014 - "However, 1321N1 astrocytoma cells, which lack any endogenous P2Y1 receptors, did not display a reduction. "
02/10/2011 - "ADPr increased [Ca(2+)](i) in transfected human astrocytoma cells (1321N1) that express human P2Y1 receptors, but not in untransfected astrocytoma cells. "
05/01/2005 - "We now show that Ca2+ release evoked by P2Y1 receptors expressed in 1321-N1 astrocytoma cells is markedly potentiated by small increases in external K+ concentration. "
11/01/1997 - "1. The rat homologue of the P2Y1 receptor has been heterologously expressed in 1321N1 human astrocytoma cells and in C6 rat glioma cells. "
|4.||Venous Thrombosis (Deep-Vein Thrombosis)
08/01/2012 - "The current study demonstrates that P2Y1 deletion or antagonism significantly reduced venous thrombosis in mice, suggesting that P2Y1 receptors play a role in the pathogenesis of venous thrombosis, at least in this species. "
06/01/2003 - "These results demonstrate a role for the P2Y1 receptor in both arterial and venous thrombosis, further establishing this receptor as a potential target for antithrombotic drugs."
06/01/2003 - "In the present work, we used models of localized arterial and venous thrombosis to assess the role of the P2Y1 receptor in these processes. "
|5.||Alzheimer Disease (Alzheimer's Disease)
|1.||Adenosine Triphosphate (ATP)
|2.||Uridine Triphosphate (UTP)
|3.||Type C Phospholipases
|4.||Purinergic P2Y1 Receptors
|5.||p38 Mitogen-Activated Protein Kinases
|7.||Adenylate Cyclase (Adenylyl Cyclase)
|8.||Adenosine Diphosphate (ADP)
|10.||pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid
|1.||Homologous Transplantation (Allograft)
|2.||Drug Therapy (Chemotherapy)