Purinergic P2Y1 Receptors

A subclass of purinergic P2Y receptors that have a preference for ATP and ADP. The activated P2Y1 receptor signals through the G-PROTEIN-coupled activation of PHOSPHOLIPASE C and mobilization of intracellular CALCIUM.

Also Known As:

Receptors, Purinergic P2Y1; P2Y1 Purinoceptor; P2Y1 Purinoceptors; P2Y1 Receptor; P2Y1 Receptors; Purinergic Receptor P2Y, G-Protein Coupled, 1; Purinoceptor P2Y1; P2Y1 Receptors, Purinergic; Purinoceptor, P2Y1; Purinoceptors, P2Y1; Receptor, P2Y1; Receptors, P2Y1

Networked: 98 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gachet, Christian: 5 articles (01/2020 - 07/2003)
2.	Gachet, C: 4 articles (06/2003 - 07/2001)
3.	Kandhavelu, Meenakshisundaram: 3 articles (01/2022 - 12/2019)
4.	Le, Hien Thi Thu: 3 articles (01/2022 - 12/2019)
5.	Murugesan, Akshaya: 3 articles (01/2022 - 12/2019)
6.	Yli-Harja, Olli: 3 articles (01/2022 - 12/2019)
7.	Lechleiter, James D: 3 articles (10/2021 - 01/2014)
8.	Jacobson, Kenneth A: 3 articles (01/2020 - 07/2005)
9.	Beitz, Alvin J: 3 articles (01/2017 - 01/2014)
10.	Choi, Hoon-Seong: 3 articles (01/2017 - 01/2014)

Related Diseases

1.	Thrombosis (Thrombus) 12/01/2001 - "Studies in P2Y1-knockout mice and experimental thrombosis models using selective P2Y1 antagonists have shown that the P2Y1 receptor, like the P2Y12 receptor, is a potential target for new antithrombotic drugs." 07/01/2001 - "Studies in P2Y1 knock-out mice and experimental thrombosis models using selective P2Y1 antagonists have shown that the P2Y1 receptor, like the P2Y12 receptor, is a potential target for new antithrombotic drugs." 07/01/2023 - "Loss of P2Y1 receptor desensitization does not impact hemostasis or thrombosis despite increased platelet reactivity in vitro." 11/01/2015 - "In this review, we focus on the specific role of the 3 platelet P2 receptors P2Y1, P2Y12, and P2X1 in hemostasis and arterial thrombosis. " 01/01/2003 - "Overall, these findings emphasize the importance of the P2Y1 receptor in hemostasis and thrombosis and suggest that variable expression levels of this receptor on platelets might play a role in thrombotic states in human, which remains to be assessed."
2.	Traumatic Brain Injuries (Traumatic Brain Injury) 12/01/2015 - "Moreover, antagonists of the P2Y1 receptor, one of the most abundant P2Y receptor subtypes in brain tissue, decreased neuronal loss and improved spatial memory in rats after traumatic brain injury (TBI). " 01/01/2022 - "Anti-inflammatory effect of P2Y1 receptor blocker MRS2179 in a rat model of traumatic brain injury." 01/01/2013 - "Finally, the most promising therapeutic candidate from our in vitro screen (MRS 2179, a P2Y1 receptor antagonist) also improves histological and cognitive outcomes in a preclinical model of traumatic brain injury. "
3.	Astrocytoma (Pilocytic Astrocytoma) 11/01/1996 - "A3P5PS, A3P5P, and adenosine-2',5'-diphosphate also were competitive antagonists in studies with the cloned human P2Y1 receptor stably expressed in 1321N1 human astrocytoma cells. " 05/01/2014 - "However, 1321N1 astrocytoma cells, which lack any endogenous P2Y1 receptors, did not display a reduction. " 02/10/2011 - "ADPr increased [Ca(2+)](i) in transfected human astrocytoma cells (1321N1) that express human P2Y1 receptors, but not in untransfected astrocytoma cells. " 05/01/2005 - "We now show that Ca2+ release evoked by P2Y1 receptors expressed in 1321-N1 astrocytoma cells is markedly potentiated by small increases in external K+ concentration. " 11/01/1997 - "1. The rat homologue of the P2Y1 receptor has been heterologously expressed in 1321N1 human astrocytoma cells and in C6 rat glioma cells. "
4.	Alzheimer Disease (Alzheimer's Disease) 11/27/2000 - "In the present study, the distribution of the P2Y1 receptor was investigated in Alzheimer's disease (AD) brains. " 01/01/2018 - "P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model." 11/19/2014 - "Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model." 01/01/2016 - "The findings discussed here may explain how P2Y1 receptor activation during brain injury, hypoxia, inflammation, schizophrenia, or Alzheimer's disease leads to an impairment of cognitive processes. "
5.	Seizures (Absence Seizure) 01/01/2019 - "Recent studies of P2Y1 receptor function in seizures and epilepsy have produced contradictory results, suggesting that the role of this receptor during seizure pathology may be highly sensitive to context. " 02/16/2023 - "Differently expression of the metabotropic P2Y receptor family after hypoxia-induced seizures in neonates and seizure suppression via P2Y1 receptor agonism." 01/01/2023 - "Besides that, other components from the ATPergic signalling cascade such as the metabotropic P2Y receptors (e.g., P2Y1 receptor) and ATP-release channels (e.g., pannexin-1), have also been shown to contribute to seizures and epilepsy. "

Related Drugs and Biologics

1.	Purinergic P2Y Receptor Antagonists
2.	Adenosine Triphosphate (ATP)
3.	Glutamic Acid (Glutamate)
4.	Lactic Acid (Lactate)
5.	Purinergic P2 Receptors (ADP Receptor)
6.	Calcium Channels (Calcium Channel)
7.	Glucose (Dextrose)
8.	Adenosine Diphosphate (ADP)
9.	Nucleotides
10.	Purinergic P2Y1 Receptors

Related Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation)
2.	Electroacupuncture
3.	Therapeutics
4.	Spinal Injections
5.	Injections