Cysteine Loop Ligand-Gated Ion Channel Receptors

A subfamily of ligand-gated ion channel receptors that share a characteristic loop which is formed by a disulfide bond between two CYSTEINE residues. These receptors typically contain five subunits with the cysteine-loop occurring near an N-terminal extracellular domain.

Also Known As:

Cys-Loop Receptor Superfamily; Cys-Loop Receptors; Cys Loop Receptor; Cys Loop Receptor Superfamily; Cys Loop Receptors; Cysteine Loop Ligand Gated Ion Channel Receptor; Cysteine Loop Ligand Gated Ion Channel Receptors; Receptor Superfamily, Cys-Loop; Receptor, Cys-Loop; Receptors, Cys-Loop; Superfamily, Cys-Loop Receptor; Cys-Loop Receptor; Cysteine Loop Ligand-Gated Ion Channel Receptor

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Ligand-Gated Ion Channels: 221
        Cysteine Loop Ligand-Gated Ion Channel Receptors: 14
        Nicotinic Receptors: 3452
        GABA-A Receptors: 2216
        5-HT3 Serotonin Receptors: 909
        Glycine Receptors: 484
        human ZACN protein
  - Membrane Proteins: 10078

Experts

1.	Gouaux, Eric: 2 articles (11/2021 - 08/2014)
2.	Zhu, Hongtao: 1 article (11/2021)
3.	Barragán Álvarez, Carla Patricia: 1 article (01/2021)
4.	Flores Fernández, José Miguel: 1 article (01/2021)
5.	Gutiérrez, Rodolfo Hernández: 1 article (01/2021)
6.	Herrera Rodríguez, Sara Elisa: 1 article (01/2021)
7.	Lagunes Quintanilla, Rodolfo Esteban: 1 article (01/2021)
8.	Martínez Velázquez, Moisés: 1 article (01/2021)
9.	Ortega, Abel Gutiérrez: 1 article (01/2021)
10.	Ramírez Rodríguez, Patricia Berenice: 1 article (01/2021)

Related Diseases

1.	Glioma (Gliomas) 05/19/2023 - "Consequently, LGICs, including purinoceptors, glutamate-gated receptors, and Cys-loop receptors, have been targeted in clinical trials for their potential therapeutic benefit in the diagnosis and treatment of gliomas. "
2.	Pain (Aches) 01/01/2015 - "Glycine receptors (GlyRs) belong to the superfamily of pentameric cys-loop receptor-operated channels and are involved in numerous physiological functions, including movement, vision, and pain. " 10/20/2020 - "The α7 nicotinic acetylcholine receptor is a homopentameric ion channel from the Cys-loop receptor superfamily targeted for psychiatric indications and inflammatory pain. " 06/05/2016 - "The glycine receptor is a member of the Cys-loop receptor superfamily of ligand-gated ion channels and is implicated as a possible therapeutic target for the treatment of diseases such as alcoholism and inflammatory pain. "
3.	Nervous System Diseases (Neurological Disorders) 01/01/2020 - "Cys-loop receptors control neuronal excitability in the brain and their dysfunction results in numerous neurological disorders. " 10/08/2015 - "Neurotransmitter-gated ion channels of the Cys-loop receptor family are essential mediators of fast neurotransmission throughout the nervous system and are implicated in many neurological disorders. "
4.	Substance-Related Disorders (Drug Abuse) 01/01/2010 - "AChRs, members of the Cys-loop receptor superfamily, have essential functional roles in the nervous system and its malfunctioning has been considered as the origin of several neurological diseases including Alzheimer's disease, drug addiction, depression, and schizophrenia. "
5.	Tick Infestations 01/01/2021 - "Immunoprotection evaluation of the recombinant N-terminal domain of Cys-loop receptors against Rhipicephalus (Boophilus) microplus tick infestation."

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Purinergic Receptors (Receptors, Purine)
3.	Ion Channels (Ion Channel)
4.	Glycine Receptors (Glycine Receptor)
5.	Ligand-Gated Ion Channels
6.	Neurotransmitter Agents (Neurotransmitter)
7.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
8.	Ionotropic Glutamate Receptors
9.	Venoms
10.	Proteins (Proteins, Gene)