Virus-Like Particle Vaccines

Vaccines using supra-molecular structures composed of multiple copies of recombinantly expressed viral structural proteins. They are often antigentically indistinguishable from the virus from which they were derived.

Also Known As:

Vaccines, Virus-Like Particle; Particle Vaccine, Virus-Like; Particle Vaccines, Virus-Like; Vaccine, Virus-Like Particle; Vaccines, Virus Like Particle; Virus Like Particle Vaccine; Virus Like Particle Vaccines; Virus-Like Particle Vaccine

Networked: 101 relevant articles (25 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ward, Brian J: 8 articles (01/2022 - 12/2010)
2.	Landry, Nathalie: 7 articles (01/2022 - 12/2010)
3.	Kang, Sang-Moo: 6 articles (01/2017 - 01/2010)
4.	Trépanier, Sonia: 5 articles (01/2022 - 12/2010)
5.	Barr, Eliav: 5 articles (04/2009 - 11/2006)
6.	Peng, Zhikang: 4 articles (07/2019 - 11/2007)
7.	Ferris, Daron G: 4 articles (12/2011 - 11/2004)
8.	Giacoletti, Katherine E D: 4 articles (12/2011 - 11/2006)
9.	Wheeler, Cosette M: 4 articles (12/2011 - 06/2007)
10.	Paavonen, Jorma: 4 articles (04/2009 - 06/2007)

Related Diseases

1.	Infections 06/30/2007 - "Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial." 11/13/2004 - "Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial." 08/01/2012 - "Norovirus virus-like particle vaccine may provide protection against infection after challenge with a homologous virus." 01/01/2019 - "Since its inception as a surrogate preclinical model for high-risk human papillomavirus (HPV) infections, the SfPV1/rabbit model has been widely used to study viral-host interactions and has played a pivotal role in the successful development of three prophylactic virus-like particle vaccines. " 09/13/2023 - "Self-Assembled Virus-Like Particle Vaccines via Fluorophilic Interactions Enable Infection Mimicry and Immune Protection."
2.	Human Influenza (Influenza) 01/01/2020 - "Efficacy of a plant-produced virus-like particle vaccine in chickens challenged with Influenza A H6N2 virus." 10/07/2014 - "As an approach to improve cross-protection in the presence of pre-existing strain-specific immunity, we investigated the efficacy of heterologous and heterosubtypic protection in previously vaccinated mice at earlier times after subsequent immunization with conserved-antigenic target influenza M2 ectodomain (M2e) virus-like particle vaccine (M2e5× VLP). " 08/01/2021 - "Preparation and evaluation of virus-like particle vaccine against H3N8 subtype equine influenza." 12/01/2017 - "A Single Intramuscular Dose of a Plant-Made Virus-Like Particle Vaccine Elicits a Balanced Humoral and Cellular Response and Protects Young and Aged Mice from Influenza H1N1 Virus Challenge despite a Modest/Absent Humoral Response." 12/12/2016 - "Influenza H7N9 LAH-HBc virus-like particle vaccine with adjuvant protects mice against homologous and heterologous influenza viruses."
3.	Uterine Cervical Neoplasms (Cancer of the Cervix) 10/01/2000 - "Developing HPV virus-like particle vaccines to prevent cervical cancer: a progress report." 06/01/2008 - "In Phase II/III trials, administration of quadrivalent human papillomavirus (HPV) (types 6/11/16/18) L1 virus-like-particle vaccine was highly effective in preventing HPV6/11/16/18-related cervical intraepithelial neoplasia and non-invasive cervical cancer in women aged 16-26 years who were naïve to these HPV types at enrollment. " 05/07/2007 - "Two HPV L1 virus-like particle vaccines have been developed, a quadrivalent HPV16/18/6/11 product and a bivalent HPV16/18 product; both have been shown to be highly immunogenic with a good safety profile and 100% efficacy against HPV16/18-related high-grade cervical intra-epithelial neoplasia (CIN2/3), implying that they will be effective at preventing HPV16/18-related cervical cancer." 05/01/2008 - "This vaccine is a prophylactic AS04 adjuvanted bivalent L1 virus-like-particle vaccine against human papillomavirus types 16 and 18, which together account for approximately 70% of cervical cancers worldwide. " 03/01/2007 - "Cervarix--a bivalent L1 virus-like particle vaccine for prevention of human papillomavirus type 16- and 18-associated cervical cancer."
4.	Neoplasms (Cancer) 03/01/2010 - "The prophylactic HPV L1 virus like particle vaccines are highly efficacious preventing >98% of HPV 16/18 caused high grade cervical intra-epithelial neoplasia (CIN2/3) according to protocol group in phase III randomized clinical trials over approximately 4 years. " 09/01/2005 - "Recently, chimeric virus-like particle vaccines have been developed to treat existing human papillomavirus-induced neoplasms. " 05/07/2007 - "Two HPV L1 virus-like particle vaccines have been developed, a quadrivalent HPV16/18/6/11 product and a bivalent HPV16/18 product; both have been shown to be highly immunogenic with a good safety profile and 100% efficacy against HPV16/18-related high-grade cervical intra-epithelial neoplasia (CIN2/3), implying that they will be effective at preventing HPV16/18-related cervical cancer." 04/01/2020 - "Bovine papillomavirus prostate cancer antigen virus-like particle vaccines are efficacious in advanced cancers in the TRAMP mouse spontaneous prostate cancer model." 04/01/2008 - "Whereas routine screening of female patients with Papanicolaou tests helps prevent advanced stages of cancer through early detection and treatment, the recently developed HPV L1 capsid protein virus-like particle vaccines offer an option for prevention of HPV-related diseases, including cervical cancer."
5.	Influenza in Birds (Avian Flu) 01/01/2022 - "A Single Vaccination of Chimeric Bivalent Virus-Like Particle Vaccine Confers Protection Against H9N2 and H3N2 Avian Influenza in Commercial Broilers and Allows a Strategy of Differentiating Infected from Vaccinated Animals." 01/01/2021 - "Single dose of multi-clade virus-like particle vaccine protects chickens against clade 2.3.2.1 and clade 2.3.4.4 highly pathogenic avian influenza viruses." 11/19/2020 - "Virus-like Particle Vaccines: A Prospective Panacea Against an Avian Influenza Panzootic." 05/23/2011 - "H9N2 avian influenza virus-like particle vaccine provides protective immunity and a strategy for the differentiation of infected from vaccinated animals." 01/22/2009 - "Influenza-pseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge."

Related Drugs and Biologics

1.	Vaccines
2.	GTP-Binding Proteins (G-Protein)
3.	Hemagglutinins (Hemagglutinin)
4.	Proteins (Proteins, Gene)
5.	Epitopes
6.	Peptides (Polypeptides)
7.	Neutralizing Antibodies
8.	Antigens
9.	Papillomavirus Vaccines (HPV Vaccines)
10.	Transforming Growth Factor beta1 (TGF beta 1)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy