EP1 Subtype Prostaglandin E Receptors

A subtype of prostaglandin E receptors that specifically couples to GTP-BINDING PROTEIN ALPHA SUBUNIT, GQ and the subsequently activates TYPE C PHOSPHOLIPASES. Additional evidence has shown that the receptor can act through a calcium-dependent signaling pathway.

Also Known As:

Receptors, Prostaglandin E, EP1 Subtype; PGE Receptor, EP1 Subtype; Prostaglandin E Receptor 1; Prostaglandin E2 Receptor, EP1 Subtype; Prostanoid Receptor EP1; EP1, Prostanoid Receptor

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Eicosanoid Receptors: 13
        Prostaglandin Receptors: 143
        Prostaglandin E Receptors: 196
        EP1 Subtype Prostaglandin E Receptors: 8
        human PTGER1 protein
        mouse Ptger1 protein
        rat Ptger1 protein

Experts

1.	Ito, Takashi: 1 article (10/2018)
2.	Jia, Huijuan: 1 article (10/2018)
3.	Kato, Hisanori: 1 article (10/2018)
4.	Miura, Fumihito: 1 article (10/2018)
5.	Miyoshi, Moe: 1 article (10/2018)
6.	Otani, Lila: 1 article (10/2018)
7.	Saito, Kenji: 1 article (10/2018)
8.	Sato, Masayuki: 1 article (10/2018)
9.	Shirahige, Katsuhiko: 1 article (10/2018)
10.	Harano, N: 1 article (01/2018)

Related Diseases

1.	Hypertension (High Blood Pressure) 10/05/2018 - "In the present study, we focus on DNA methylation profiles of prostaglandin E receptor 1 gene (ptger1), which is known to be associated with hypertension. "
2.	Hyperalgesia 12/15/1995 - "In the present study, we examined the effect of the PGE receptor EP1 subtype antagonist ONO-NT-012, the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, and the NO synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME) on the allodynia. "
3.	Oral Ulcer (Mouth Ulcer) 01/01/2018 - "Spontaneous nociceptive behavior in oral ulcer model rats was inhibited by swab applications of BQ-788 (ETB receptor antagonist), ONO-8711 (prostanoid receptor EP1 antagonist), and HC-030031 (TRPA1 antagonist). "
4.	Pain (Aches) 10/01/2011 - "The prostanoid receptor EP1 is a G-protein-coupled receptor (GPCR) known to be involved in a variety of pathological disorders such as pain, fever and inflammation. "
5.	Neoplasms (Cancer) 09/01/2001 - "Thus, we have shown that skin tumor cells depend in part on PGE(2) signaling through the EP1 prostanoid receptor for their in vitro growth."

Related Drugs and Biologics

1.	NG-Nitroarginine Methyl Ester (L-NAME)
2.	Nitric Oxide Synthase (NO Synthase)
3.	Dizocilpine Maleate (Dizocilpine)
4.	N-Methylaspartate (NMDA)
5.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
6.	ONO-NT 012
7.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
8.	Prostaglandins E
9.	Phosphotransferases (Kinase)
10.	2- (1,3- dimethyl- 2,6- dioxo- 1,2,3,6- tetrahydro- 7H- purin- 7- yl)- N- (4- isopropylphenyl)acetamide