Sorting Nexins

A large family of phosphatidylinositol phosphate-binding proteins that are involved in mediating intracellular transport and sorting of proteins via a variety of endocytic pathways.

Also Known As:

Networked: 114 relevant articles (0 outcomes, 12 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Shen, Xiaoyan: 9 articles (01/2021 - 01/2016)
2.	You, Yan: 7 articles (01/2021 - 01/2016)
3.	Wang, Xin: 5 articles (07/2021 - 04/2013)
4.	Jose, Pedro A: 5 articles (02/2021 - 01/2013)
5.	Hu, Bin: 5 articles (01/2021 - 02/2016)
6.	Zhang, Sulin: 5 articles (01/2021 - 02/2016)
7.	Xu, Huaxi: 4 articles (07/2021 - 04/2013)
8.	Armando, Ines: 4 articles (02/2021 - 01/2013)
9.	Shen, Weixing: 4 articles (01/2021 - 01/2016)
10.	Villar, Van Anthony M: 4 articles (01/2020 - 01/2013)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "In xenograft-based studies, SNX27-depleted cell lines showed prolonged survival of SCID mice, suggesting a possible implication for overexpression of the sorting nexin in tumor samples." 04/01/2017 - "However, studies of the association of sorting nexin 10 with different types of cancer are limited, prompting further study. " 01/01/2021 - "The molecular structure and function of sorting nexin 10 in skeletal disorders, cancers, and other pathological conditions." 01/01/2020 - "Sorting nexin 16 (SNX16), a member of the sorting nexin family, has been implicated in tumor development. " 01/01/2020 - "Sorting nexin (SNX) family members are associated with tumor progression. "
2.	Osteopetrosis 04/01/2023 - "In this study, we describe a 4-year-old boy with increased bone density due to osteopetrosis, autosomal recessive 8. Using genome sequencing, we identified a large deletion in the 5'-untranslated region (UTR) of SNX10 (sorting nexin 10), where the regulatory region of this gene is located. " 12/01/2014 - "Sorting nexin 10 (SNX10), the unique member of the SNX family having vacuolation activity in cells, was shown to be involved in the development of autosomal recessive osteopetrosis (ARO) in recent genetic studies. " 01/01/2021 - "In this article we describe one such "error of nature," namely the development of acute recessive osteopetrosis (ARO) in humans that is caused by mutations in sorting nexin 10 (SNX10) that affect OCL functioning. " 01/01/2021 - "Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From Osteopetrosis." 01/01/2021 - "Homozygosity for the R51Q mutation in sorting nexin 10 (SNX10) inactivates osteoclasts (OCLs) and induces autosomal recessive osteopetrosis in humans and in mice. "
3.	Virus Diseases (Viral Diseases) 01/01/2021 - "Previous studies have identified an interaction between the human papillomavirus (HPV) L2 minor capsid protein and sorting nexins 17 and 27 (SNX17 and SNX27) during virus infection. " 01/01/2013 - "Previous studies have shown that the human papillomavirus type 16 (HPV-16) L2 capsid protein plays an essential role in viral infection, in part through its interaction with sorting nexin 17 (SNX17). " 12/24/2020 - "Underlying their importance, genetic defects in sorting nexins are linked with a variety of human diseases including neurodegenerative, cardiovascular diseases, viral infections, and cancer. " 10/01/2015 - "We show that small interfering RNA (siRNA)-mediated knockdown of SNX27 alone leads to a marginal reduction in the efficiency of viral infection but that double knockdown of both sorting nexins results in a striking reduction in infection, greater than that observed for the knockdown of either sorting nexin alone. "
4.	Neoplasm Metastasis (Metastasis) 12/01/2020 - "Using in vivo and in vitro models, we further investigated the effect of sorting nexins 3 on tumor growth and metastasis and underling mechanism. " 03/09/2016 - "Here, we identify sorting nexin 9 (SNX9) as a new regulator of breast cancer metastasis. " 12/15/2010 - "Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression." 12/01/2020 - "In vitro study showed that sorting nexins 3 knockdown suppressed esophageal adenocarcinoma cell invasion, metastasis, and epithelial-mesenchymal translation (EMT) process, and this result was confirmed by in vivo tumor metastasis assays. " 12/01/2020 - "Our data provided strong evidence that sorting nexins 3 played a critical role in esophageal adenocarcinoma metastasis through Wnt/β-catenin signal pathway."
5.	Infections 01/01/2021 - "This study shows that the newly identified retriever complex also plays an important role and begins to shed light on how both sorting nexins contribute to retromer and retriever recruitment during the infection process." 01/01/2021 - "We also show that both sorting nexins may interact with either of the recycling complexes but that the interaction between SNX17 and HPV16 L2 is not responsible for retriever recruitment during infection, instead being required for retromer recruitment. " 10/01/2017 - "Sorting nexin (MoVps17) is required for fungal development and plant infection by regulating endosome dynamics in the rice blast fungus." 01/01/2019 - "We performed a screen utilizing a direct virus-cell fusion assay as readout and identified several host proteins involved in endosomal trafficking/maturation, including Rab5A and sorting nexins, as factors regulating HIV-1 fusion and infection. " 10/01/2015 - "We show that small interfering RNA (siRNA)-mediated knockdown of SNX27 alone leads to a marginal reduction in the efficiency of viral infection but that double knockdown of both sorting nexins results in a striking reduction in infection, greater than that observed for the knockdown of either sorting nexin alone. "

Related Drugs and Biologics

1.	Capsid Proteins (Capsid Protein)
2.	Carrier Proteins (Binding Protein)
3.	Biomarkers (Surrogate Marker)
4.	Dextran Sulfate
5.	Pilocarpine (Ocusert)
6.	Proteins (Proteins, Gene)
7.	Sorting Nexins
8.	Phosphatidylinositols (Phosphatidylinositol)
9.	Small Interfering RNA (siRNA)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Therapeutics