Calcitonin Receptor-Like Protein

A receptor protein that is associated with RECEPTOR ACTIVITY-MODIFYING PROTEINS. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 it forms the CALCITONIN GENE-RELATED RECEPTOR. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 it forms the ADRENOMEDULLIN RECEPTOR.

Also Known As:

Calcitonin Receptor Like Protein; Calcitonin Receptor Like Receptor; Receptor-Like Protein, Calcitonin; Receptor-Like Receptor, Calcitonin; Calcitonin Receptor-Like Receptor

Networked: 59 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Calcitonin Receptor-Like Protein: 59
        human CALCRL protein
        mouse Calcrl protein
        rat Calcrl protein

Experts

1.	Caron, Kathleen M: 6 articles (01/2020 - 04/2006)
2.	Kechele, Daniel O: 3 articles (01/2018 - 01/2016)
3.	Born, Walter: 3 articles (08/2015 - 10/2007)
4.	Fischer, Jan A: 3 articles (08/2015 - 10/2007)
5.	Rees, Margaret C P: 3 articles (10/2013 - 10/2006)
6.	Green, Kortney E: 3 articles (05/2007 - 04/2005)
7.	Kangawa, Kenji: 3 articles (01/2005 - 02/2003)
8.	Guo, Sun-Wei: 2 articles (02/2021 - 01/2019)
9.	Liu, Xishi: 2 articles (02/2021 - 01/2019)
10.	Yu, Long-Chuan: 2 articles (01/2021 - 06/2013)

Related Diseases

1.	Ileitis 01/08/2013 - "Local injection of dsRNA targeting calcitonin receptor-like receptor (CLR) ameliorates Clostridium difficile toxin A-induced ileitis."
2.	Pre-Eclampsia (Preeclampsia) 01/07/2021 - "Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study." 04/01/2005 - "The present study was designed to investigate the expression of CGRP receptor components, calcitonin receptor-like receptor (CRLR), and receptor activity modifying protein 1 (RAMP1), and the relaxation response to CGRP in fetoplacental vessels from normotensive pregnant women and women with preeclampsia. " 03/01/2009 - "To determine placental gene expression of calcitonin gene-related peptide (CGRP), calcitonin receptor-like receptor (CRLR), receptor activity modifying protein 1 (RAMP1), and endothelial and inducible nitric oxide synthases (eNOS and iNOS) in mild preeclampsia, and to assess the effects of magnesium sulfate (MgSO4). "
3.	Neoplasms (Cancer) 05/01/2006 - "CRLR (calcitonin receptor-like receptor) and CD 117, the gene product of c-kit have been shown to be expressed in cells of glial tumors, especially in those with higher malignancy. " 11/29/2022 - "AM impacts angiogenesis and tumor growth and binds to calcitonin receptor-like receptor/receptor activity-modifying protein 2 or 3 (CLR/RAMP2; CLR/RAMP3). " 10/01/2006 - "Calcitonin receptor-like receptor (CL) is a G protein-coupled receptor (GPCR) that mediates effects of AM, but little information is available on its expression and functional state in human tumors. " 08/01/2009 - "ADM is thought to act through the G protein-coupled receptor calcitonin receptor-like receptor, with specificity being conferred by receptor-associated modifying protein 2. The aim of the present study was to clarify the roles of ADM status, and tumor vessels in endometrium. " 09/15/2005 - "Because neuropeptide calcitonin is secreted by prostate tumors and endothelial cells are known to express calcitonin receptor-like receptor, we examined the potential action of calcitonin on endothelial cells. "
4.	Angle-Closure Glaucoma (Glaucoma, Angle Closure) 01/01/2008 - "In the present study, acutely and transiently elevated IOP, characteristic of acute angle-closure glaucoma in humans, was observed in CLR (calcitonin receptor-like receptor) transgenic mice between 1 and 3 months of age. " 08/01/2015 - "Therefore, we investigated PAX6 expression in wild-type and calcitonin receptor-like receptor transgenic (CLR(SMαA)) mice with angle-closure glaucoma. " 10/27/2009 - "To determine whether the polymorphisms of calcitonin receptor-like receptor gene (CALCRL) are associated with primary angle closure glaucoma (PACG) in a southern Chinese population. "
5.	Hydrops Fetalis (Fetal Edema) 04/01/2006 - "Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene." 05/01/2007 - "Recent studies have shown that homozygous knockout of gene for calcitonin gene-related peptide (CALCA) receptor component, calcitonin receptor-like receptor (CALCRL), led to extreme hydrops fetalis and embryonic death, underlining the critical role of CALCA in embryonic development and fetal growth. " 01/01/2018 - "We report the first case of nonimmune hydrops fetalis (NIHF) associated with a recessive, in-frame deletion of V205 in the G protein-coupled receptor, Calcitonin Receptor-Like Receptor (hCALCRL). "

Related Drugs and Biologics

1.	Clostridium difficile tcdA protein
2.	Adrenomedullin
3.	Calcitonin Gene-Related Peptide
4.	Receptor Activity-Modifying Protein 2
5.	Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)
6.	Proteins (Proteins, Gene)
7.	Receptor Activity-Modifying Proteins
8.	Receptor Activity-Modifying Protein 1
9.	Messenger RNA (mRNA)
10.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)

Related Therapies and Procedures

1.	Ligation
2.	Therapeutics