Receptor Activity-Modifying Protein 1

A receptor activity-modifying protein that is a subunit of specific G-PROTEIN COUPLED RECEPTORS. The CALCITONIN GENE-RELATED PEPTIDE RECEPTOR is formed from a dimer of this protein and CALCITONIN RECEPTOR-LIKE PROTEIN, while an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.

Also Known As:

Networked: 29 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tsujikawa, Kazutake: 4 articles (10/2020 - 07/2011)
2.	Russo, Andrew F: 3 articles (01/2019 - 07/2009)
3.	Guo, Sun-Wei: 2 articles (02/2021 - 01/2019)
4.	Liu, Xishi: 2 articles (02/2021 - 01/2019)
5.	Abboud, Francois M: 2 articles (01/2019 - 03/2010)
6.	Chapleau, Mark W: 2 articles (01/2019 - 03/2010)
7.	Kuburas, Adisa: 2 articles (01/2019 - 07/2009)
8.	Sabharwal, Rasna: 2 articles (01/2019 - 03/2010)
9.	Shi, Bei: 2 articles (03/2014 - 08/2012)
10.	Fukada, So-ichiro: 2 articles (01/2012 - 07/2011)

Related Diseases

1.	Migraine Disorders (Migraine) 07/08/2009 - "Our findings demonstrate that a single gene, receptor activity-modifying protein 1 (RAMP1), can be a modifier of photophobia and, by extension, suggest that genetic or epigenetic modulation of RAMP1 levels may contribute to migraine susceptibility. " 02/15/2013 - "This study investigates whether variants in the gene that encodes CGRP, calcitonin-related polypeptide alpha (CALCA) or in the gene that encodes a component of its receptor, receptor activity modifying protein 1 (RAMP1), are associated with migraine pathogenesis and susceptibility. " 01/01/2015 - "Receptor activity modifying protein 1(RAMP1) is a key receptor subunit of calcitonin gene related peptide (CGRP) playing a critical role in migraine. " 07/25/2018 - "[Manual Acupuncture Stimulation Regulates Expression of Receptor Activity-modifying Protein 1 and 5-HT 1 D Receptor Proteins and Genes in Migraine Rats]." 05/01/2011 - "CGRP, an important mediator of migraine pathogenesis, and the 3 components of its receptor, calcitonin-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and receptor component protein (RCP) mRNAs were quantified in the trigeminal ganglion and medulla to identify baseline sex differences and changes associated with application of IS or PBS to the dura. "
2.	Pain (Aches) 01/01/2012 - "CGRP binds to CGRP receptors composed of receptor activity-modifying protein 1 (RAMP1) and calcitonin receptor-like receptor (CLR) to modulate various functions such as pain transmission and vasodilation. " 06/07/2013 - "Although the release of CGRP is well observed in pain-related regions after chronic morphine treatment, a lack of evidence is obvious for the expression of CGRP-receptor subunits, calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) in the brain. " 01/01/2022 - "Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) implicates peripherally-released CGRP in migraine pain. "
3.	Pre-Eclampsia (Preeclampsia) 04/01/2005 - "The present study was designed to investigate the expression of CGRP receptor components, calcitonin receptor-like receptor (CRLR), and receptor activity modifying protein 1 (RAMP1), and the relaxation response to CGRP in fetoplacental vessels from normotensive pregnant women and women with preeclampsia. " 03/01/2009 - "To determine placental gene expression of calcitonin gene-related peptide (CGRP), calcitonin receptor-like receptor (CRLR), receptor activity modifying protein 1 (RAMP1), and endothelial and inducible nitric oxide synthases (eNOS and iNOS) in mild preeclampsia, and to assess the effects of magnesium sulfate (MgSO4). "
4.	Chronic Hepatitis B 06/10/2020 - "[Study on the correlation between prognosis of patients with chronic hepatitis B under interferon treatment and polymorphism of both calcitonin gene related peptide and receptor activity modifying protein 1]." 06/10/2020 - "Objective: To analyze the association of two single-nucleotide polymorphisms (SNP) [Calcitonin gene related peptide (CGRP) rs155209 and receptor activity modifying protein 1 (RAMP1) rs3754701] and the prognosis of chronic hepatitis B patients who were under interferon therapy. "
5.	Myocardial Infarction 08/14/2012 - "To observe the effects of mesenchymal stem cells (MSC) modified by human receptor activity-modifying protein 1 (hRAMP1) on restenosis and cardiac function post-myocardial infarction (MI) and explore the therapeutic safety for gene modification of MSC. " 03/01/2014 - "Transplantation of mesenchymal stem cells carrying the human receptor activity-modifying protein 1 gene improves cardiac function and inhibits neointimal proliferation in the carotid angioplasty and myocardial infarction rabbit model." 03/01/2014 - "Here, we investigated the effects of MSCs overexpressing the human receptor activity-modifying protein 1 (hRAMP1) on heart function and artery repair in rabbit models of myocardial infarction (MI) reperfusion and carotid artery injury. "

Related Drugs and Biologics

1.	Calcitonin Gene-Related Peptide
2.	Calcitonin Receptors (Calcitonin Receptor)
3.	Monoclonal Antibodies
4.	Calcitonin Receptor-Like Protein
5.	Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)
6.	Interferons
7.	Procalcitonin
8.	Proteins (Proteins, Gene)
9.	Substance P
10.	Neuropeptides

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Muscle Denervation
4.	Percutaneous Collagen Induction