Acute Kidney Injury (Acute Renal Failure)

Abrupt reduction in kidney function defined as an absolute increase in serum CREATININE of more than or equal to 0.3. mg/dl, a percentage increase in serum creatinine of more than or equal to 50%, or a reduction in urine output. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Also Known As:
Acute Renal Failure; Acute Kidney Failure; Acute Kidney Insufficiency; Acute Renal Injury; Acute Renal Insufficiency; Kidney Failure, Acute; Kidney Insufficiency, Acute; Renal Failure, Acute; Renal Insufficiency, Acute; Acute Kidney Failures; Acute Kidney Injuries; Acute Kidney Insufficiencies; Acute Renal Failures; Acute Renal Injuries; Acute Renal Insufficiencies; Kidney Failures, Acute; Kidney Injuries, Acute; Kidney Injury, Acute; Kidney Insufficiencies, Acute; Renal Failures, Acute; Renal Injuries, Acute; Renal Injury, Acute; Renal Insufficiencies, Acute
Networked: 14438 relevant articles (574 outcomes, 1224 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Sepsis (Septicemia)
2. Ischemia
3. Critical Illness (Critically Ill)
4. Chronic Kidney Failure (Chronic Renal Failure)
5. Inflammation


1. Bellomo, Rinaldo: 127 articles (12/2015 - 01/2002)
2. Ronco, Claudio: 96 articles (12/2015 - 01/2002)
3. Devarajan, Prasad: 84 articles (01/2016 - 12/2004)
4. Kellum, John A: 78 articles (01/2016 - 01/2002)
5. Bagshaw, Sean M: 69 articles (12/2015 - 08/2004)
6. Parikh, Chirag R: 62 articles (12/2015 - 07/2004)
7. Garg, Amit X: 50 articles (12/2015 - 12/2005)
8. Wald, Ron: 44 articles (12/2015 - 01/2006)
9. Bonventre, Joseph V: 44 articles (11/2015 - 01/2002)
10. Goldstein, Stuart L: 43 articles (12/2015 - 09/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Kidney Injury:
1. Cisplatin (Platino)FDA LinkGeneric
2. Glycerol (Glycerine)FDA LinkGeneric
3. CreatinineIBA
12/01/2011 - "Patients who met acute kidney injury criteria after adjustment of creatinine for fluid balance (but not before) had a mortality rate that was significantly greater than those who did not meet acute kidney injury criteria both before and after adjustment for fluid balance (31% vs. 12%, p < .001) and those who had acute kidney injury before but not after adjustment for fluid balance (31% vs. 11%, p = .005). "
09/01/2010 - "There was a significantly greater loss of kidney function among the TDF recipients, compared with control subjects (mean difference in calculated creatinine clearance, 3.92 mL/min; 95% confidence interval [CI], 2.13-5.70 mL/min), as well as a greater risk of acute renal failure (risk difference, 0.7%; 95% CI, 0.2-1.2). "
02/01/2012 - "Adding the urine albumin to creatinine ratio to the clinical model to predict acute kidney injury improved the area under the curve from 0.67 to 0.70 (P < .001), and the continuous net reclassification improvement was 29% (P < .001). "
06/01/2010 - "Acute renal failure was defined as 25% decrease from baseline of estimated creatinine clearance and estimated creatinine clearance of 60 mL/min or less on postoperative day 3. Owing to differences in preoperative characteristics between groups, propensity score analysis was used to adjust those differences. "
01/01/2010 - "In patients with acute kidney injury, glomerular filtration rate estimating equations can be improved by incorporating data on creatinine generation and fluid balance. "
4. Biological Markers (Surrogate Marker)IBA
5. Gentamicins (Gentamicin)FDA LinkGeneric
6. Furosemide (Lasix)FDA LinkGeneric
7. Uranyl NitrateIBA
8. Dopamine (Intropin)FDA LinkGeneric
9. VancomycinFDA LinkGeneric
10. Acetylcysteine (Siran)FDA LinkGeneric

Therapies and Procedures

1. Renal Dialysis (Hemodialysis)
2. Renal Replacement Therapy (Therapies, Renal Replacement)
3. Peritoneal Dialysis
4. Transplantation (Transplant Recipients)
5. Resuscitation