Transcription Factor 3

A basic helix-loop-helix transcription factor that plays a role in determining cell fate during embryogenesis. It forms a heterodimer with TWIST TRANSCRIPTION FACTOR and ACHAETE-SCUTE GENE COMPLEX-related TRANSCRIPTION FACTORS.
Also Known As:
E12 Helix-Loop-Helix Protein; E2A Immunoglobulin Enhancer Binding Factor E12; E2A Immunoglobulin Enhancer Binding Factor E47; E47 Helix-Loop-Helix Protein; Immunoglobulin Transcription Factor 1; Pan-1 DNA-Binding Protein; Pan-2 DNA-Binding Protein; Transcription Factor 3, Isoform E12; Transcription Factor 3, Isoform E47; kappa-E2-Binding Factor; DNA-Binding Protein, Pan-1; DNA-Binding Protein, Pan-2; E12 Helix Loop Helix Protein; E47 Helix Loop Helix Protein; Factor, kappa-E2-Binding; Helix-Loop-Helix Protein, E12; Helix-Loop-Helix Protein, E47; Pan 1 DNA Binding Protein; Pan 2 DNA Binding Protein; Transcription Factor E2 alpha; kappa E2 Binding Factor; Transcription Factor E2-alpha
Networked: 136 relevant articles (1 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Yamamoto, Kazuhide: 6 articles (08/2013 - 01/2011)
2. Shiraha, Hidenori: 6 articles (08/2013 - 01/2011)
3. Matsubara, Minoru: 4 articles (08/2013 - 01/2011)
4. Horiguchi, Shigeru: 4 articles (08/2013 - 01/2011)
5. Yagi, Takahito: 4 articles (08/2013 - 01/2011)
6. Iwamuro, Masaya: 4 articles (08/2013 - 01/2011)
7. Wang, Shuai: 3 articles (04/2014 - 01/2013)
8. Wang, Zhou: 3 articles (04/2014 - 01/2013)
9. Chen, Hua-Xia: 3 articles (04/2014 - 01/2013)
10. Kang, Kyoung Ah: 3 articles (11/2013 - 04/2012)

Related Diseases

1. Neoplasms (Cancer)
2. Glioma (Gliomas)
3. Hepatocellular Carcinoma (Hepatoma)
4. Carcinoma (Carcinomatosis)
5. Melanoma (Melanoma, Malignant)
05/01/2008 - "In this study, we investigated the expression of forkhead/winged helix transcription factor 3 (Foxp3) in melanoma-invaded LNs and determined proportion and functionality of Treg cells among TIL extracted from these 10 metastatic melanoma LNs at different steps of their in vitro expansion. "
04/28/2015 - "Niclocelle, a niclosamide loaded rigid core mixed micelle, was synthesized from a self-assembled well-defined amphiphilic diblock copolymer and an FDA-approved signal transducer and activator of transcription factor 3. Followed by a rigorous physico-chemical characterization, niclocelles were evaluated biologically for cytotoxicity and apoptosis in human melanoma (C32) and breast cancer (MDA-MB231 and MCF-7) cells. "
11/01/2005 - "Each specimen was assessed by quantitative real-time reverse transcriptase polymerase chain reaction for expression of four melanoma-associated markers: melanoma antigen recognized by T cells 1; beta1 --> 4-N-acetylgalactosaminyltransferase; paired box homeotic gene transcription factor 3; and melanoma antigen gene-A3 family, and the changes of CTCs during treatment and prognostic effect of CTCs after overall treatment on recurrence and survival were investigated. "
07/01/2004 - "PE SLNs (n = 308) from these patients were sectioned and assessed by qRT for mRNA of four melanoma-associated genes: MART-1 (antigen recognized by T cells-1), MAGE-A3 (melanoma antigen gene-A3 family), GalNAc-T (beta1-->4-N-acetylgalactosaminyl-transferase), and Pax3 (paired-box homeotic gene transcription factor 3). "
03/01/2015 - "Thirty-two cases of primary mediastinal seminomas were reviewed; and representative whole-tissue sections were selected for immunohistochemical studies using antibodies directed against high molecular weight cytokeratin 5/6 (CK5/6), low molecular weight cytokeratin (CAM5.2), octamer-binding transcription factor 3/4 (OCT3/4), spalt-like transcription factor 4 (SALL4), GATA binding protein 3 (GATA-3), sry-related HMG box 2 (SOX2), SOX17, human T cell leukemia/lymphoma 1 (TCL1), glypican 3, melanoma associated antigen C2 (MAGEC2), and paired box gene 8 (Pax8). "

Related Drugs and Biologics

1. Transcription Factors (Transcription Factor)
2. Keratins (Keratin)
3. Antigens
4. Glypicans
5. Cisplatin (Platino)
6. Carrier Proteins (Binding Protein)
7. Azacitidine (5 Azacytidine)
8. Antibodies
9. Keratin-5 (Keratin 5)
10. Chromatin

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Heterologous Transplantation (Xenotransplantation)
3. Photochemotherapy (Photodynamic Therapy)