|1.||Balk, Steven P: 2 articles (03/2013 - 02/2006)|
|2.||Deng, Ling-Xiao: 1 article (12/2015)|
|3.||Wang, Qian: 1 article (12/2015)|
|4.||Qiao, Wei-Zhen: 1 article (12/2015)|
|5.||Kikuchi, Alex: 1 article (12/2015)|
|6.||Shou, Weinian: 1 article (12/2015)|
|7.||Singh, Sucha: 1 article (12/2015)|
|8.||Xu, Yan-Juan: 1 article (12/2015)|
|9.||Zhou, Lili: 1 article (12/2015)|
|10.||Cui, Hua: 1 article (12/2015)|
|1.||Colorectal Neoplasms (Colorectal Cancer)
10/15/2010 - "Inactivation of the Apc gene is recognized as the key early event in the development of sporadic colorectal cancer (CRC), where its loss leads to constitutive activation of β-catenin/T-cell factor 4 signaling and hence transcription of Wnt target genes such as c-Myc. "
08/01/2015 - "[T Cell Factor 4, beta-catenin and SFRP1 Expression of Wnt Signaling Pathway in Colorectal Carcinoma and the Prognosis]."
02/01/2013 - "We identified promoter regions of 960 genes that interacted with the Wnt pathway nuclear effector T-cell factor 4 in 4 different human colorectal cancer-derived cell lines; 18 of these promoters were present in all chromatin precipitates. "
10/01/2015 - "Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells."
04/01/2007 - "Likewise, a significant reduction in the development and growth of colorectal tumors was found in Villin-Cre Foxm1-/- mice compared with Foxm1 fl/fl mice after AOM/DSS treatment, which was associated with decreased expression of cyclin A2, cyclin B1, survivin, and T-cell factor 4 genes. "
01/01/2015 - "The objective of this study was to explore the prognostic role of T cell factor 4 (TCF4) expression in predicting tumor response to nCRT and tumor outcomes for patients with LARC. "
01/01/2012 - "The TCF7L2 transcription factor is linked to a variety of human diseases, including type 2 diabetes and cancer. "
03/22/2011 - "T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis."
08/01/2015 - "Abnormal activation of Wnt signaling pathway is closely related to the occurrence of tumor, and T cell factor 4 (Tcf4 ) and beta-catenin are important signal transmission factors of this pathway. "
07/17/2009 - "T cell factor 4 (TCF4) interacts with beta-catenin in the WNT signaling pathway and transactivates downstream target genes involved in cancer progression. "
|3.||Breast Neoplasms (Breast Cancer)
03/01/2013 - "SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/β-catenin activation in breast cancer."
03/23/2012 - "MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells."
12/30/2011 - "Tumor-suppressive effects of psoriasin (S100A7) are mediated through the β-catenin/T cell factor 4 protein pathway in estrogen receptor-positive breast cancer cells."
01/01/2013 - "The decreased expression of Wnt/β-Catenin targeting genes, such as cyclin D1, C-myc and survivin, and the inhibition of the activity of the transcription factor (T-cell factor 4, TCF-4) were observed in GL-treated breast cancer cells. "
05/15/2009 - "We studied the effects of TZDs on DNA synthesis (BrdU enzyme-linked immunosorbent assay), gene expression (microarray, quantitative reverse transcription-polymerase chain reaction, and immunoblot), serine phosphorylation and localization of beta-catenin (nuclear/cytoplasmic fractionation and immunoblot), transactivation activity of beta-catenin/T cell factor 4 (TCF4) (luciferase assay with wild-type and mutant TCF4 responsive element), and beta-catenin/TCF4 complex (immunoprecipitation) in human breast cancer cells MDA-MB-231 and T47D. "
|4.||Prostatic Neoplasms (Prostate Cancer)
|5.||Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
07/01/2005 - "In addition, the regulation of SERCA3 expression was analyzed in the context of the adenomatous polyposis coli/beta-catenin/T-cell factor 4 (TCF4) pathway and of specificity protein 1 (Sp1)-like factor-dependent transcription. "
01/01/2011 - "A tumor suppressor gene, Adenomatous polyposis coli (Apc), is expressed in the nervous system from embryonic to adulthood stages, and transmits the Wnt signaling pathway in which schizophrenia susceptibility genes, including T-cell factor 4 (TCF4) and calcineurin (CN), are involved. "
|6.||Transcription Factors (Transcription Factor)
|7.||Androgen Receptors (Androgen Receptor)
|9.||Estrogen Receptor beta