Septins

A family of GTP-binding proteins that were initially identified in YEASTS where they were shown to initiate the process of septation and bud formation. Septins form into hetero-oligomeric complexes that are comprised of several distinct septin subunits. These complexes can act as cytoskeletal elements that play important roles in CYTOKINESIS, cytoskeletal reorganization, BIOLOGICAL TRANSPORT, and membrane dynamics.

Also Known As:

Networked: 320 relevant articles (2 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mostowy, Serge: 12 articles (04/2022 - 10/2009)
2.	Talbot, Nicholas J: 9 articles (01/2021 - 02/2013)
3.	Kinoshita, Makoto: 9 articles (01/2018 - 12/2005)
4.	Montagna, Cristina: 7 articles (10/2021 - 05/2003)
5.	Spiliotis, Elias T: 7 articles (10/2021 - 01/2006)
6.	Mabjeesh, Nicola J: 7 articles (01/2019 - 04/2009)
7.	Tulassay, Zsolt: 7 articles (07/2017 - 05/2009)
8.	Trimble, William S: 7 articles (01/2017 - 05/2002)
9.	Russell, S E Hilary: 7 articles (03/2006 - 12/2003)
10.	Ryder, Lauren S: 6 articles (01/2021 - 02/2013)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 09/01/2018 - "This study aimed to investigate the detection of methylated Septin 9 (mSEPT9) in Korean patients with colorectal cancer (CRC) and compare the results with those of previous studies. " 10/01/2023 - "The septin 9 blood test is indicated for colorectal cancer screening in individuals who decline first-line tests, but participation in this context is unclear. " 10/01/2022 - "Expression of Septin 2 and Her2/neu in Colorectal Cancer." 10/01/2022 - "Septin 9 is the most frequently reported hypermethylated gene in colorectal cancer (CRC). " 04/15/2022 - "The Septin 9 test analyzes the methylation status of the SEPT9 gene, which appears to be hypermethylated in patients with colorectal cancer (CRC). "
2.	Neoplasms (Cancer) 01/01/2023 - "This study identifies potential targets for treating entosis-associated tumors, showing that Orai1 is an entotic Ca2+ channel that provides essential Ca2+ signaling and sheds light on the molecular mechanism underlying entosis that involves SEPTIN filaments, Orai1, and MLCK." 01/01/2021 - "Here, we build upon our septin studies to develop a new approach for identifying chaperone interactions in living cells, and use it to expand our understanding of chaperone involvement, kinetic folding delays, and oligomerization in the recessive behavior of tumor-derived mutants of the tumor suppressor p53. " 01/01/2019 - "Background: Aberrant hypermethylation of the Septin 9 (SEPT9) is an early event in several human cancers, and increasing studies have reported good performance of methylated SEPT9 (mSEPT9) in cancer diagnosis. " 05/01/2010 - "In this study, we examined the expression pattern of the other 13 known septin genes in altogether 67 cases of myeloid neoplasia, including three patients with the MLL-SEPT2 fusion gene, four with MLL-SEPT6 fusion, and three patients with the MLL-SEPT9 fusion gene. " 01/01/2006 - "Hence, studies of these molecules might provide new insights not only into how cells coordinate their functions, but also into the pathogenesis of cancer and other diseases in which septins are abnormally expressed."
3.	Infections 01/01/2019 - "In this Review, we discuss a selection of mechanistic insights recently gained from studying three infection paradigms: the rice blast fungus Magnaporthe oryzae, the poxvirus family member vaccinia virus and the Gram-negative bacterium Shigella flexneri These studies have respectively discovered that higher-order septin assemblies enable fungal invasion into plant cells, entrap viral particles at the plasma membrane and recognize dividing bacterial cells for delivery to lysosomes. " 01/01/2019 - "Moreover, infection biology studies have illuminated important roles for septins in mediating the outcome of host-microbe interactions. " 10/01/2012 - "These studies demonstrate that not only are septins important for cytokinesis, but they also promote polarized morphogenesis and selection of germ tube sites that may help disseminate an infection in host tissues." 09/27/2010 - "However, in contrast to studies in other fungal pathogens, in which septins were reported to be necessary during the infection process, we found a minor role of septins during corn infection by U. " 11/29/2023 - "Septins of some pathogenic fungi are involved in morphological changes related to infection. "
4.	Schizophrenia (Dementia Praecox) 07/01/2004 - "Altered levels of the septin CDCrel-1 in isolation-reared rats may contribute to changes in neuronal connectivity and neurotransmission, and suggest a potential role for CDCrel-1 in schizophrenia related to chromosome 22q11 deletion syndrome." 08/01/2011 - "Additionally, the expression of septin 7 and OPA1, proteins downstream of truncated p35, is decreased in schizophrenia. " 01/01/2018 - "This review focuses on the structure, function and mechanism of septin 7 in vivo, and summarizes the role of septin 7 in cell proliferation, cytokinesis, nervous and reproductive systems, as well as the underlying molecular events linking septin 7 to various diseases, such as Alzheimer's disease, schizophrenia, neuropsychiatric systemic lupus erythematosus, tumour and so on." 08/11/2013 - "Together, these data indicate that septin dysregulations commonly found in postmortem human brains with Parkinson's disease, schizophrenia and bipolar disorders may be responsible for a subset of behavioral abnormalities in the patients." 04/01/2009 - "This finding in mouse models is in agreement with the recent findings that qualitative and/or quantitative dysregulation of septins is involved in neurodegenerative disorders such as Parkinson disease and psychological disorders such as schizophrenia and bipolar disorder. "
5.	Neoplasm Metastasis (Metastasis) 10/01/2022 - "This study aimed to assess the clinical relevance of Septin 9 methylation in regional lymph nodes in recurrence/metastases of CRC. " 01/01/2022 - "Here, we aimed to explore whether LSD1 affects the metastasis of NSCLC by mediating Septin 6 (SEPT6) through the TGF-β1 pathway. " 02/28/2022 - "Methylated septin 9 gene is an important prognostic marker in stage II and stage III colorectal cancer for evaluating local recurrence or distant metastasis after surgery." 01/01/2016 - "In this minireview, we focus on the importance of the subunit composition and subcellular localization of septins relevant to tumor initiation, progression, and metastasis. " 01/01/2020 - "This study provides evidence that Cdc42EP5 is a regulator of cancer cell motility that coordinates actin and septin networks and describes a unique role for SEPT9 in melanoma invasion and metastasis."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Proteins (Proteins, Gene)
3.	Biomarkers (Surrogate Marker)
4.	Septins
5.	GTP-Binding Proteins (G-Protein)
6.	Messenger RNA (mRNA)
7.	Chemokines
8.	Peptides (Polypeptides)
9.	Ligands
10.	Epidermal Growth Factor (EGF)

Related Therapies and Procedures

1.	Therapeutics