Neglected Diseases

Diseases that are underfunded and have low name recognition but are major burdens in less developed countries. Neglected diseases include many tropical infectious diseases, e.g., HELMINTHIASIS; LEPROSY; LYMPHATIC FILARIASIS; ONCHOCERCIASIS; SCHISTOSOMIASIS; and TRACHOMA.

Also Known As:

Networked: 962 relevant articles (37 outcomes, 66 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chagas Disease (American Trypanosomiasis)
2.	Leishmaniasis
3.	Schistosomiasis (Bilharziasis)
4.	Visceral Leishmaniasis (Kala Azar)
5.	Infections

Experts

1.	Hotez, Peter J: 24 articles (01/2021 - 04/2006)
2.	Keiser, Jennifer: 14 articles (03/2021 - 10/2007)
3.	Maes, Louis: 13 articles (07/2022 - 08/2009)
4.	Utzinger, Jürg: 11 articles (11/2017 - 01/2006)
5.	Bottazzi, Maria Elena: 10 articles (01/2021 - 04/2006)
6.	Pollastri, Michael P: 9 articles (03/2017 - 08/2011)
7.	Kaiser, Marcel: 8 articles (01/2021 - 12/2010)
8.	de Moraes, Josué: 7 articles (01/2022 - 01/2014)
9.	Anderson, Roy M: 7 articles (12/2021 - 01/2013)
10.	Brun, Reto: 7 articles (09/2015 - 04/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neglected Diseases:

1.	VaccinesIBA 01/01/2023 - "The availability and accessibility of safe and effective drugs, vaccines, and diagnostics are essential to reducing the immense global burden of neglected tropical diseases (NTDs). " 10/01/2023 - "This study provides a platform that would be useful to develop other suitable vaccine candidates to prevent helminthic neglected tropical diseases in near future." 06/01/2012 - "Advances in vaccines against neglected tropical diseases: enhancing physical stability of a recombinant hookworm vaccine through biophysical and formulation studies." 11/30/2022 - "A strategic model for developing vaccines against neglected diseases: An example of industry collaboration for sustainable development." 11/01/2022 - "The designed vaccine has shown the required effectiveness against MPXV without any side effects, a significant milestone against the neglected disease."
2.	Antiparasitic Agents (Antiparasitics)IBA 07/15/2018 - "The development of safe and affordable antiparasitic agents effective against neglected tropical diseases is a big challenge of the drug discovery. " 07/01/2018 - "In this brief review article, we will provide an overview of the current situation regarding antiparasitic molecules derived from filamentous fungi, in particular, those which are effective against protozoan parasites, such as Plasmodium, Trypanosoma, and Leishmania, vectors of some neglected tropical diseases. " 10/10/2023 - "Exploring the Potential of Natural Products as Antiparasitic Agents for Neglected Tropical Diseases." 02/27/2021 - "The discovery of novel antiparasitic drugs for neglected tropical diseases (NTDs) constitutes a global urgency and requires a range of innovative strategies to ensure a sustainable pipeline of lead compounds. " 01/01/2019 - "All isolated altenuisol derivatives were screened for their antiparasitic activities, which provide a preliminary structure-activity relationship of this class of compounds against neglected tropical diseases."
3.	Proteins (Proteins, Gene)FDA Link 08/01/2021 - "Altogether, these results are consistent with those from other functional SGT proteins and add to the understanding of the PQC system in Aedes aegypti, an important aim that may help to develop inhibitory strategies against this vector of neglected diseases." 01/01/2023 - "Editorial: Computational approaches to build therapeutic paradigms targeting genes, proteins and pathways against neglected tropical diseases (NTDs)." 05/27/2019 - "As a consequence, the proteins involved in Leishmania apoptosis seem a target of choice for the development of new therapeutic tools against these neglected tropical diseases. " 01/01/2018 - "The protein obtained can be used to explore novel strategies to induce immunity against Leishmania sp. or it can be employed in diagnostic kits to detect this neglected disease." 01/01/2017 - "Inhibition of Protein-Protein Interactions: New Options for Developing Drugs against Neglected Tropical Diseases."
4.	benzonidazole (benznidazole)IBA 01/01/2014 - "The nitroheterocycle benznidazole is currently used to treat this neglected tropical disease, although this drug causes severe side effects and has limited efficacy during the chronic phase of the disease. " 05/01/2014 - "The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). " 09/01/2012 - "Benznidazole shortage makes chagas disease a neglected tropical disease in developed countries: data from Spain." 08/01/2016 - "After the publication of the results of the BENEFIT study concluding that the benznidazole (5 mg/kg/d/60 d) is ineffective to stop the progression of the established Chagas' cardiomyopathy in adults, the author evokes the new experiences and the new challenges of 2016 regarding Chagas disease while speculating on its future and by calling back some elements little known of his history, in particular the fact that it is Chagas who invented about it to some extent the concept of "neglected disease". " 11/08/2021 - "The treatment of this neglected disease relies on benznidazole and nifurtimox, two nitroheterocyclic drugs that show limited efficacy and severe side effects. "
5.	fexinidazoleIBA 01/01/2018 - "Fexinidazole could be a key asset in the elimination of this fatal neglected disease. " 02/19/2020 - "The Drugs for Neglected Disease initiative (DNDi), founded in 2003, has developed the first all oral therapy for both stage 1 and stage 2 HAT in fexinidazole. " 12/01/2015 - "In response to these concerns, the Drugs for Neglected Diseases Initiative (DNDi), an independent nonprofit organization founded by a coalition of public sector and international organizations, developed a mechanism to facilitate more effective and efficient host country ethics review for a study of the use of fexinidazole for the treatment of late stage African Trypanosomiasis (HAT). " 01/01/2019 - "Fexinidazole and Human African Trypanosomiasis: good news for this important neglected tropical disease." 12/21/2010 - "Here it is shown that fexinidazole, a 2-substituted 5-nitroimidazole rediscovered by the Drugs for Neglected Diseases initiative (DNDi) after extensive compound mining efforts of more than 700 new and existing nitroheterocycles, could be a short-course, safe and effective oral treatment curing both acute and chronic HAT and that could be implemented at the primary health care level. "
6.	Praziquantel (Biltricide)FDA Link 01/01/2021 - "The control and treatment of this neglected tropical disease is based on a single drug, praziquantel, which raises concerns about the development of drug resistance. " 01/01/2017 - "Although the disease threatens millions of lives, it is still at the top list of neglected tropical diseases and praziquantel, the only common schistosocidal drug in use, has records of decreasing efficiency and cases of resistance. " 09/01/2018 - "Growing resistance to therapy with praziquantel (PZQ) has encouraged the search for novel treatments against this neglected disease. " 01/09/2014 - "The national neglected tropical disease control program started mass drug administration (MDA) with praziquantel (PZQ) in six districts in 2009 targeting primary school children only. " 11/15/2010 - "For its treatment, praziquantel remains the only effective drug available and the dependence on this sole chemotherapy emphasizes the urgent need for new drugs to control this neglected disease. "
7.	4-nitroimidazoleIBA 12/21/2010 - "Here it is shown that fexinidazole, a 2-substituted 5-nitroimidazole rediscovered by the Drugs for Neglected Diseases initiative (DNDi) after extensive compound mining efforts of more than 700 new and existing nitroheterocycles, could be a short-course, safe and effective oral treatment curing both acute and chronic HAT and that could be implemented at the primary health care level. " 09/01/2012 - "Fexinidazole, a 2-substituted 5-nitroimidazole rediscovered by the Drugs for Neglected Diseases initiative (DNDi) after extensive compound mining of public and pharmaceutical company databases, has the potential to become a short-course, safe and effective oral treatment, curing both acute and chronic HAT. " 01/01/2012 - "Fexinidazole, a 2-subsituted 5-nitroimidazole drug candidate rediscovered following extensive compound mining by the Drugs for Neglected Diseases initiative and currently in Phase I clinical study for the treatment of human African trypanosomiasis, was evaluated in experimental models of acute and chronic CD caused by different strains of Trypanosoma cruzi. "
8.	Ivermectin (Mectizan)FDA Link 01/01/2021 - "Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). " 01/01/2019 - "Yearly, millions of children are treated globally with ivermectin mainly for neglected tropical diseases. " 01/01/2017 - "The success of ivermectin in driving two of the most devastating and disfiguring neglected tropical diseases (NTD) to the brink of elimination has been well documented. " 05/01/2008 - "Much of the experience gained in the development of ivermectin mass treatment can be usefully applied in the recent broader perspective of control of neglected tropical diseases. " 01/01/2020 - "Integrating ivermectin distribution into chemoprophylaxis strategies for other neglected diseases could increase coverage in a cost-effective manner."
9.	AntigensIBA 01/01/2013 - "The novel antigens identified here may have potential use in both the development of new tests and the improvement of currently available assays for diagnosing this neglected tropical disease. " 01/01/2023 - "The proposed protocol allowed us to obtain genus-specific antigens that can be developed and reproduced in all laboratories in Brazil and South America, where paracoccidioidomycosis is a neglected disease, contributing to an early diagnosis, especially in endemic regions, regardless of the species. " 10/01/2021 - "In silico analysis may have an even more important role when information concerning antigens from etiologic agents of neglected diseases, such as leprosy, is scarce. " 01/01/2014 - "The challenge of producing skin test antigens with minimal resources suitable for human application against a neglected tropical disease; leprosy." 03/01/2014 - "These findings illustrate the potential use of rLdccys1 as an additional tool for the immunotherapy of canine visceral leishmaniasis and support further studies designed to improve the efficacy of this recombinant antigen for the treatment of this neglected disease."
10.	NitroimidazolesIBA 12/01/2019 - "Drugs for Neglected Diseases initiative (DNDi) has identified three chemical lead series, the nitroimidazoles, benzoxaboroles and aminopyrazoles, as innovative treatments for visceral leishmaniasis. " 01/01/2018 - "Three new chemical series (bicyclic nitroimidazoles, aminopyrazoles and oxaboroles) were selected by Drugs for Neglected Diseases initiative as potential new drug leads for leishmaniasis. " 10/17/2022 - "The screening of the Drugs for Neglected Diseases initiative (DNDi) HAT-library by the Swiss TPH had singled out fexinidazole, originally developed by Hoechst (now Sanofi), as the most promising of a series of over 800 nitroimidazoles and related molecules. " 06/01/2011 - "The Drugs for Neglected Diseases initiative (DNDi) rediscovered a nitroimidazole, fexinidazole, which is currently in Phase I clinical trials. " 05/01/2014 - "Benznidazole (Bzn) is a nitroimidazole drug currently used as first line treatment against Chagas disease, a neglected tropical disease caused by the flagellated protozoan Trypanosoma cruzi. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/2015 - "Monitoring the efficacy of drugs for neglected tropical diseases controlled by preventive chemotherapy." 03/01/2020 - "Penicillium being a polyextremophile Antarctic species, exhibited strong biological activities and the presence of aromatic compounds in its extracts may indicate that they are wild ancient strains with high genetic and biochemical potentials that enable them to produce bioactive compounds which can be researched in further studies and used in the chemotherapy of neglected tropical diseases as well as in agriculture." 10/24/2007 - "Using a MEDLINE search (1966 through June 2007), randomized controlled trials (RCTs) were reviewed that examined simultaneous treatment of 2 or more of the 7 most prevalent neglected tropical diseases using oral drug therapy. " 01/01/2023 - "Challenges of implementation of the preventive chemotherapy neglected tropical diseases programme in Ghana." 12/01/2022 - "By 2020, the World Health Organization and the Ghana Neglected Tropical Diseases programme intended to treat 75% and 100% of school-age children, respectively, during preventative chemotherapy (PCT), to control soil-transmitted helminths. "
2.	Mass Drug Administration 01/01/2019 - "Additionally, combined mass administration of drugs for two or more neglected diseases has potential practical advantages, but efficacy of potential combinations should be confirmed. " 07/05/2021 - "It has been identified as one of the Neglected Tropical Diseases that can be controlled and even eliminated through mass drug administration and other effective interventions. " 06/30/2022 - "Mass drug administration (MDA) of antimicrobials has shown promise in the reduction and potential elimination of a variety of neglected tropical diseases (NTDs). " 05/16/2023 - "This study examines the effectiveness of the neglected tropical disease (NTD) mass drug administration (MDA) campaign approach as a means to deliver UHC, using the example of the Liberia national programme. " 11/01/2020 - "Few studies have been done of patterns of treatment during mass drug administration (MDA) to control neglected tropical diseases. "
3.	Therapeutics 01/01/2013 - "Neglected tropical diseases constitute a significant public health burden, affecting over one billion people globally, yet this group of diseases is underrepresented in the appropriation of both monetary and intellectual capital for developing improved therapies and public health campaigns. " 01/01/2013 - "These studies support the use of HTS assays and reprofiling FDA-approved drugs for new therapy for neglected tropical diseases." 09/01/2023 - "Determining the fungal pathogen in skin-related fungal neglected tropical diseases (NTDs) determines optimal therapy. " 01/01/2023 - "Recent approaches in nanocarrier-based therapies for neglected tropical diseases." 01/01/2022 - "Drug associations as alternative and complementary therapy for neglected tropical diseases."
4.	Immunotherapy 01/01/2014 - "Immunotherapy and Immunochemotherapy in Visceral Leishmaniasis: Promising Treatments for this Neglected Disease." 03/01/2014 - "These findings illustrate the potential use of rLdccys1 as an additional tool for the immunotherapy of canine visceral leishmaniasis and support further studies designed to improve the efficacy of this recombinant antigen for the treatment of this neglected disease."
5.	Vertebroplasty 03/01/2001 - "Vertebroplasty for osteoporotic compression fracture: effective treatment for a neglected disease."