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Dent Disease

X-linked recessive NEPHROLITHIASIS characterized by HYPERCALCIURIA; HYPOPHOSPHATEMIA; NEPHROCALCINOSIS; and PROTEINURIA. It is associated with mutations in the voltage-gated chloride channel, CLC-5 (Dent Disease I). Another group of mutations associated with this disease is in phosphatidylinositol 4,5-bisphosphate-5-phosphatase gene.
Also Known As:
Dents Disease; Disease, Dent; Disease, Dent's; Disease, Dents; Dent's Disease
Networked: 136 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Bartter Syndrome (Syndrome, Bartter)
2. Hypercalciuria
3. Nephrolithiasis
4. Hypophosphatemia
5. Oculocerebrorenal Syndrome (Lowe Syndrome)

Experts

1. Devuyst, Olivier: 13 articles (09/2015 - 04/2003)
2. Thakker, Rajesh V: 12 articles (04/2013 - 01/2002)
3. Ludwig, Michael: 8 articles (01/2011 - 01/2003)
4. Thakker, R V: 8 articles (11/2001 - 01/2000)
5. Igarashi, Takashi: 7 articles (07/2014 - 01/2002)
6. Scheinman, Steven J: 7 articles (01/2009 - 01/2002)
7. Blanchard, Anne: 6 articles (08/2015 - 01/2006)
8. Norden, Anthony G W: 6 articles (02/2012 - 01/2002)
9. Guggino, William B: 6 articles (05/2008 - 04/2003)
10. De Camilli, Pietro: 5 articles (01/2014 - 05/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dent Disease:
1. CalciumIBA
2. Chloride Channels (Chloride Channel)IBA
3. Proteins (Proteins, Gene)IBA
4. Hydrochlorothiazide (Esidrix)FDA LinkGeneric
5. Dent disease 1IBA
6. Vitamin A (Retinol)FDA LinkGeneric
7. Peroxidase (Myeloperoxidase)IBA
8. RNA (Ribonucleic Acid)IBA
9. Genetic Markers (Genetic Marker)IBA
10. Protons (Proton)IBA

Therapies and Procedures

1. Transplants (Transplant)
2. Nephrectomy