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Striae Distensae

Linear dermal scars accompanied by epidermal atrophy that affects skin that is subjected to continuous stretching. They usually do not cause any significant medical problems, only cosmetic problems.
Also Known As:
Stretch Marks; Distensae, Striae; Mark, Stretch; Marks, Stretch; Stretch Mark
Networked: 97 relevant articles (12 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Cicatrix (Scar)
2. Keloid
3. Cellulitis
4. Wounds and Injuries (Trauma)
5. Phlebitis

Experts

1. Strumia, Renata: 3 articles (01/2013 - 01/2005)
2. Bayat, Ardeshir: 2 articles (09/2015 - 09/2013)
3. Lee, Sang-Jun: 2 articles (12/2012 - 01/2007)
4. Song, Kye-Yong: 2 articles (12/2012 - 01/2007)
5. Suh, Dong-Hye: 2 articles (12/2012 - 01/2007)
6. Vogt, Peter M: 2 articles (10/2010 - 04/2008)
7. Hinek, Aleksander: 2 articles (10/2010 - 11/2005)
8. Aust, Matthias C: 2 articles (10/2010 - 04/2008)
9. Mitts, Thomas F: 2 articles (10/2010 - 11/2005)
10. Muratori, G: 2 articles (09/2003 - 09/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Striae Distensae:
1. Tretinoin (Retinoic Acid)FDA LinkGeneric
2. NitrogenIBA
3. Carbon MonoxideIBA
4. ElastinIBA
11/01/2005 - "Skin biopsies from normal subjects (NS), stretch-marked skin (SM), and normal-looking skin from patients with stretch marks (NL) were analyzed by histochemistry and assays of total protein, DNA, and elastin. "
08/01/1998 - "Analysis of these data reveals: 1) both regimens can improve the appearance of stretch marks; 2) these topical therapy regimens are safe and effective in study patients with minimal irritation; 3) elastin content within the reticular and papillary dermis can increase with topical 20% glycolic acid combined with 0.05% tretinoin emollient cream therapy; 4) both regimens increased epidermal thickness and decreased papillary dermal thickness in treated stretch marks when compared with untreated stretch marks; 5) combined epidermal and papillary dermal thickness in stretch marks treated with either topical regimen approaches that of normal skin; and 6) profilometry can objectively measure differences in skin texture associated with striae treatments when compared to controls, however, it is not sensitive enough to justify comparison or quantitative improvements between similarly effective treatments."
10/01/2010 - "Because aldosterone applied alone stimulates both collagen and elastin deposition in cultures of fibroblasts and in cultures of skin explants derived from dermal stretch marks, we postulate that this steroid should be used in the treatment of damaged skin that loses its volume and elasticity. "
07/01/1994 - "These observations suggest that expression of collagens, elastin and fibronectin genes are apparently decreased, and that there is a marked alteration of fibroblast metabolism, in striae distensae."
01/01/2000 - "Compared to placebo, treatment with a cream containing Centella asiatica extract, alpha tocopherol and collagen-elastin hydrolysates was associated with less women developing stretch marks (odds ratio 0.41, 95% confidence interval 0.17 to 0.99). "
5. glycolic acid (glycolate)IBA
6. atelocollagenIBA
7. Centella asiatica extractIBA
8. GelsIBA
9. CollagenIBA
10. Carbon DioxideIBA

Therapies and Procedures

1. Lasers (Laser)
2. Dye Lasers
3. Gas Lasers
4. Solid-State Lasers
5. Optical Devices