Striae Distensae

Linear dermal scars accompanied by epidermal atrophy that affects skin that is subjected to continuous stretching. They usually do not cause any significant medical problems, only cosmetic problems.

Also Known As:

Networked: 209 relevant articles (34 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Striae Distensae
2.	Alopecia (Baldness)
3.	Cicatrix (Scar)
4.	Weight Loss (Weight Reduction)
5.	Keloid

Experts

1.	Hersant, Barbara: 5 articles (01/2022 - 01/2019)
2.	La Padula, Simone: 5 articles (01/2022 - 01/2019)
3.	Meningaud, Jean Paul: 5 articles (01/2022 - 01/2019)
4.	D'Andrea, Francesco: 4 articles (01/2022 - 01/2021)
5.	Errico, Concetta: 4 articles (01/2022 - 01/2021)
6.	Persichetti, Paolo: 4 articles (01/2022 - 01/2021)
7.	Pizza, Chiara: 4 articles (01/2022 - 01/2021)
8.	Rega, Umberto: 4 articles (01/2022 - 01/2021)
9.	Guida, Stefania: 3 articles (11/2021 - 01/2018)
10.	Vogt, Peter M: 3 articles (01/2019 - 04/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Striae Distensae:

1.	Tretinoin (Retinoic Acid)FDA LinkGeneric 07/01/2001 - "In this small study, topical application of tretinoin significantly improved the clinical appearance of pregnancy-related stretch marks." 08/01/1994 - "Low-dose tretinoin does not improve striae distensae: a double-blind, placebo-controlled study." 09/25/2020 - "Based on the results of network meta-analysis, we recommend treating striae distensae with bipolar radio frequency combined topical tretinoin. " 05/01/2018 - "Platelet-Rich Plasma Versus Tretinoin in Treatment of Striae Distensae: A Comparative Study." 02/01/2013 - "Transepidermal retinoic acid delivery using ablative fractional radiofrequency associated with acoustic pressure ultrasound for stretch marks treatment."
2.	NitrogenIBA 09/01/2003 - "Study results have shown that the use of MAP, in conjunction with the ANC/OMP, has proven to be safe and effective by preventing those adverse effects associated with a negative nitrogen balance, such as oversized or flabby tissue, stretch marks, sagging of breast tissue, increased hair loss, faded hair color, and fragile or brittle nails. " 09/01/2003 - "Study results have shown that the use of MAP, in conjunction with the ANC/OMP regimen, has proven to be safe and effective by preventing those adverse effects associated with a negative nitrogen balance, such as oversized or flabby tissue, stretch marks, the sagging of breast tissue, increased hair loss, faded hair color, and fragile or brittle nails. "
3.	EmollientsIBA 01/01/2016 - "The aim of this research was to formulate an emollient water-in-oil cosmetic cream containing argan oil, which may be helpful in the prevention or early treatment of striae distensae. " 01/01/2016 - "Intensive moisturization of the lesions and use of emollient oils have been recommended for the prevention and treatment of striae distensae rubra. " 08/01/1998 - "Analysis of these data reveals: 1) both regimens can improve the appearance of stretch marks; 2) these topical therapy regimens are safe and effective in study patients with minimal irritation; 3) elastin content within the reticular and papillary dermis can increase with topical 20% glycolic acid combined with 0.05% tretinoin emollient cream therapy; 4) both regimens increased epidermal thickness and decreased papillary dermal thickness in treated stretch marks when compared with untreated stretch marks; 5) combined epidermal and papillary dermal thickness in stretch marks treated with either topical regimen approaches that of normal skin; and 6) profilometry can objectively measure differences in skin texture associated with striae treatments when compared to controls, however, it is not sensitive enough to justify comparison or quantitative improvements between similarly effective treatments."
4.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/01/2022 - "Striae Distensae: In Vitro Study and Assessment of a Combined Treatment with Sodium Ascorbate and Platelet Rich Plasma on Fibroblasts." 01/01/2022 - "Striae Distensae: In Vitro Study and Assessment of Combined Treatment with Sodium Ascorbate and Platelet-Rich Plasma on Fibroblasts." 01/01/2021 - "Invited Response on: Striae Distensae: In Vitro Study and Assessment of a Combined Treatment With Sodium Ascorbate and Platelet-Rich Plasma on Fibroblasts." 01/01/2021 - "Comment on: "Striae Distensae: In Vitro Study and Assessment of Combined Treatment with Sodium Ascorbate and Platelet-Rich Plasma on Fibroblasts"." 01/01/2021 - "Striae Distensae: In Vitro Study and Assessment of Combined Treatment With Sodium Ascorbate and Platelet-Rich Plasma on Fibroblasts."
5.	CollagenIBA 08/01/2023 - "Our results demonstrated PRP per quadrant treatment was most effective in reducing the area of the abdominal stretch marks, with consequent stimulation of the synthesis and remodeling of collagen and elastic fibers. " 01/01/2022 - "Authors present a study about the contraction forces observed in striae distensae fibroblasts (SMF) in a collagen scaffold. " 04/01/2018 - "In vivo study of dermal collagen of striae distensae by confocal Raman spectroscopy." 06/01/2023 - "The stretch mark width, skin elasticity, skin color, skin thickness, and collagen density were noninvasively measured. " 04/01/2021 - "At T2 confocal microscopy of stretch marks, dermal collagenous fibers assumed casual disposition with reticular pattern and refractivity, as signs of collagen remodeling and neocollagenesis, and also the T2 cutaneous ultrasound revealed increased epidermal thickness and decreased dermal hypoechogenicity as for a higher skin hydration. "
6.	ElastinIBA 06/01/2021 - "In addition, pro-collagen I and elastin concentrations were found to be higher in the TLE-treated stretch mark skin explants compared to the untreated ones, associated with higher quantities of TGF-β production. " 01/01/2020 - "The main differences observed when comparing skin with and without stretch marks were at depths between 75 and 95 μm, corresponding to the dermal-epidermal junction and dermis regions and showing differences between normal skin and stretched skin regarding collagen, collagen hydration, and elastin fibers. " 06/01/2021 - "Matricial proteins (pro-collagen I and elastin) and pro-matricial factors, like TGF-β concentrations, were quantified from cultures of human skin explants presenting stretch marks, treated with TLE or vehicle control. " 11/01/2005 - "Skin biopsies from normal subjects (NS), stretch-marked skin (SM), and normal-looking skin from patients with stretch marks (NL) were analyzed by histochemistry and assays of total protein, DNA, and elastin. " 07/01/1994 - "These observations suggest that expression of collagens, elastin and fibronectin genes are apparently decreased, and that there is a marked alteration of fibroblast metabolism, in striae distensae."
7.	Carbon DioxideIBA 11/01/2021 - "The aim of this study was to compare the efficacy and safety of fractional carbon dioxide (CO2 ) laser versus carboxytherapy in treatment of striae distensae. " 11/01/2010 - "Treatment of striae distensae using an ablative 10,600-nm carbon dioxide fractional laser: a retrospective review of 27 participants." 01/01/2021 - "To evaluate the safety and effectiveness of combined fractional radiofrequency microneedling (FRM) and fractional carbon dioxide (FCO2 ) laser treatment for striae distensae and to compare the results to those of FRM alone and those of FCO2 alone. " 10/01/2013 - "To evaluate the efficacy and safety of combination therapy with fractionated microneedle radiofrequency (RF) and fractional carbon dioxide (CO2) laser in the treatment of striae distensae. " 04/01/2011 - "In the current article, a review of fractional ablative resurfacing is presented alongside the results from a multi-center clinical study employing the fractional carbon dioxide (CO2) laser (SmartXide DOT, DEKA) for the treatment of rhytides, photoaging, scars and striae distensae."
8.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 02/01/2021 - "Ablative fractional CO2 laser vs lyophilized growth factor intralesional injection vs combination of both modalities for striae distensae treatment." 03/01/2020 - "Safety/Efficacy of New Topical Silicone Formulation with Selective Growth Factors for Treating Striae Distensae." 08/01/2023 - "Based on the current findings, PRP constitutes a promising therapeutic approach in patients with stretch marks, since it promoted modulation of inflammatory cytokines and growth factors, with consequent remodeling of extracellular matrix, culminating with tissue improvement." 08/01/2023 - "Incisional biopsies were collected from abdominal stretch marks with a 2 mm diameter punch in female patients, at the beginning of treatment, after 6 and 12 weeks of treatment, and submitted to morphological analyzes of elastic and collagen fibers, and immunohistochemistry for TLRs signaling pathways and growth factors. " 08/01/2023 - "The aims of this study were to characterize and to compare the structural alterations of collagen and elastic fibers in the abdominal stretch marks of patients submitted to intralesional and per quadrant (region close to stretch marks) Platelet-Rich Plasma (PRP) treatment, as well as, to establish the possible mechanisms of action of this treatment involving toll-like receptors (TLRs) signaling pathways and growth factors. "
9.	glycolic acid (glycolate)IBA 03/01/2012 - "A superficial texture analysis of 70% glycolic acid topical therapy and striae distensae." 12/17/2022 - "Regarding treatment, there are various treatment strategies currently available for stretch marks, including topical preparations such as tretinoin and glycolic acid, and also laser. " 08/01/1998 - "Analysis of these data reveals: 1) both regimens can improve the appearance of stretch marks; 2) these topical therapy regimens are safe and effective in study patients with minimal irritation; 3) elastin content within the reticular and papillary dermis can increase with topical 20% glycolic acid combined with 0.05% tretinoin emollient cream therapy; 4) both regimens increased epidermal thickness and decreased papillary dermal thickness in treated stretch marks when compared with untreated stretch marks; 5) combined epidermal and papillary dermal thickness in stretch marks treated with either topical regimen approaches that of normal skin; and 6) profilometry can objectively measure differences in skin texture associated with striae treatments when compared to controls, however, it is not sensitive enough to justify comparison or quantitative improvements between similarly effective treatments."
10.	Durapatite (Hydroxylapatite)IBA 02/01/2021 - "This study evaluated the efficacy and safety of a single treatment combining microfocused ultrasound with visualization (MFU-V) and subdermal diluted calcium hydroxylapatite with lidocaine (CaHA+) for Striae Distensae Albae (SDA). " 09/01/2017 - "Calcium Hydroxylapatite Combined with Microneedling and Ascorbic Acid is Effective for Treating Stretch Marks." 09/01/2017 - "We treat stretch marks using injections of diluted calcium hydroxylapatite (CaHA, Radiesse) filler combined with microneedling and topical ascorbic acid. "

Therapies and Procedures

1.	Gas Lasers 01/01/2022 - "Both fractional CO2 laser and carboxytherapy may be considered as safe and effective lines of treatment for striae distensae, but fractional CO2 laser showed excellent improvement clinically, radiologically when compared with carboxytherapy which made it a promising module in treatment of striae distensae." 03/01/2016 - "Fractional CO2 laser was found to be more effective in the treatment of striae distensae compared with intense pulse light." 10/01/2021 - "Efficacy of platelet-poor plasma gel in combination with fractional CO2 laser in striae distensae: A clinical, histological, and immunohistochemical study." 02/01/2021 - "Different studies had evaluated the efficacy of fractional CO2 laser and platelet-rich plasma (PRP) in treating striae distensae (SD). " 01/01/2022 - "Comparative Study Between the Efficacy of Fractional CO2 Laser/Radiofrequency, PRP and a Combination of Both in the Treatment of Striae Distensae: A Pilot Study."
2.	Lasers (Laser) 04/01/2011 - "The ablative fractional resurfacing laser was effective in the clinical improvement of striae distensae. " 01/01/2002 - "The use of lasers alone or in combination with other therapeutic modalities can provide a safe and effective reduction in the appearance of both red and white striae distensae. " 11/01/2011 - "These results support the use of nonablative fractional laser and ablative CO(2) fractional laser as effective and safe treatment modalities for striae distensae of Asian skin. " 11/01/2021 - "The efficacy of picosecond laser (PSL) in the treatment of striae distensae (SD) has been recently reported; otherwise, the base for this improvement has not been clarified yet. " 11/01/2011 - "Although a variety of laser and light sources have been used for the treatment of striae distensae, to date no definite 'gold standard' treatment modality has been determined. "
3.	Percutaneous Collagen Induction 01/01/2020 - "The clinical results obtained in this study support the safe and effective treatment of striae distensae with microneedling in light and dark skin tones in various body locations. " 09/01/2017 - "Combining 1:1 diluted CaHA with microneedling and topical ascorbic is safe and effective for treating stretch marks." 10/01/2021 - "The Use of Microneedling to Treat Striae Distensae." 01/01/2020 - "Twenty-five consecutive adults (SPT I-V) with striae distensae involving the trunk and extremities were treated using a microneedling device. " 01/01/2020 - "To describe the clinical results and side effects of microneedling in a series of 25 individuals with striae distensae. "
4.	Dye Lasers 06/01/2014 - "Efficacy of pulsed dye laser versus intense pulsed light in the treatment of striae distensae." 06/01/2014 - "Pulsed dye laser (PDL) and intense pulsed light (IPL) have been used to treat striae distensae. " 01/01/2007 - "Thirty-seven patients with abdominal striae distensae were treated with the Thermage and 585-nm pulsed dye laser in the first session at baseline. " 01/01/2007 - "Radiofrequency and 585-nm pulsed dye laser treatment of striae distensae: a report of 37 Asian patients." 04/01/1996 - "Treatment of stretch marks with the 585-nm flashlamp-pumped pulsed dye laser."
5.	Solid-State Lasers 09/01/2014 - "We suggest that variable square pulse Er: YAG and long pulse Nd: YAG lasers are not useful in the treatment of striae distensae alba." 09/01/2014 - "We compared the efficacy of 1064 nm long pulse (LP) Nd: YAG laser and 2940 nm variable square pulse (VSP) erbium: YAG laser in the treatment of striae distensae. " 01/01/2019 - "Clinical benefit of using a multifractional Er:YAG laser combined with a spatially modulated ablative (SMA) module for the treatment of striae distensae: A prospective pilot study in 20 patients." 12/01/2017 - "A pilot study of treatment of striae distensae with variable square pulse Erbium: YAG laser resurfacing." 12/01/2016 - "Comparison of the effectiveness of two fluences using long-pulsed Nd:YAG laser in the treatment of striae distensae. "