|1.||Belvisi, Laura: 4 articles (01/2016 - 05/2012)|
|2.||Gennari, Cesare: 4 articles (01/2016 - 05/2012)|
|3.||Fregona, Dolores: 4 articles (07/2014 - 03/2012)|
|4.||Celegato, Marta: 3 articles (07/2014 - 03/2012)|
|5.||Ronconi, Luca: 3 articles (07/2014 - 03/2012)|
|6.||Nardon, Chiara: 3 articles (07/2014 - 03/2012)|
|7.||Aldinucci, Donatella: 3 articles (07/2014 - 03/2012)|
|8.||Satyanarayanajois, Seetharama: 3 articles (06/2014 - 09/2009)|
|9.||Piarulli, Umberto: 3 articles (06/2013 - 05/2012)|
|10.||Spampinato, Santi: 2 articles (09/2015 - 04/2007)|
11/01/2001 - "Preclinical studies found that several RGD peptidomimetics and a monoclonal antibody to alpha(v)beta3 can inhibit tumor growth by blocking tumor-induced angiogenesis."
06/01/2015 - "These results suggest that the novel peptidomimetics we have developed target the extracellular domain of HER2 protein and inhibit HER2:HER3 interaction, providing a novel method to treat HER2-positive cancer."
07/01/2014 - "This review provides an up-to-date perspective of the complexity of cellular signaling and strategies for targeting PPIs in disease states, particularly in cancer, using peptidomimetics, and highlights that the rational design of agents that target PPIs is not only feasible but is of the utmost clinical importance."
06/01/2014 - "We have designed several peptidomimetics to block the HER2-mediated dimerization, resulting in antiproliferative activity for cancer cells. "
08/19/2013 - "1,2,3-Triazoles as amide bond mimics: triazole scan yields protease-resistant peptidomimetics for tumor targeting."
|2.||Autoimmune Diseases (Autoimmune Disease)
09/01/2015 - "These peptidomimetics could be of interest for the development of small-molecule agents effective against inflammatory processes and correlated autoimmune diseases."
09/01/1995 - "We have further tested the capacity of retro-inverso peptidomimetics to serve as possible targets for antibodies produced by lupus mice and by patients with rheumatic autoimmune diseases. "
01/01/2014 - "The design of peptides/peptidomimetics for immunomodulation in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, systemic lupus and HIV infection is reviewed. "
08/03/2006 - "BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma."
08/03/2006 - "We have studied the efficacy of BH3 peptidomimetics consisting of the minimal death, or BH3, domains of the proapoptotic BH3-only proteins Bid and Bad to induce apoptosis using neuroblastoma (NB) as a model system. "
02/01/2007 - "Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells."
02/01/2007 - "Our results suggest that (hydroxyethyl)urea peptidomimetics containing unnatural amino acid substitutions could represent a novel class of gamma-secretase inhibitors with enhanced stability, providing the basis for the further development of effective therapeutics for AD and neuroblastomas."
10/01/2008 - "Both the peptidomimetics and precursors previously developed by us are promising drug candidates, as they were found to be active against rodent Plasmodium berghei malaria and Pneumocystis carinii pneumonia. "
01/01/2011 - "This trial was conducted to evaluate the safety and immunogenicity of two virosome formulated malaria peptidomimetics derived from Plasmodium falciparum AMA-1 and CSP in malaria semi-immune adults and children. "
07/15/2010 - "Herein we report the synthesis of a series of novel constrained peptidomimetics 2-10 endowed with a dipeptide backbone (D-Ser-Gly) and a vinyl ester warhead, structurally related to a previously identified lead compound 1, an irreversible inhibitor of falcipain-2, the main haemoglobinase of lethal malaria parasite Plasmodium falciparum. "
|1.||Proteins (Proteins, Gene)
|2.||Heterologous Transplantation (Xenotransplantation)
|3.||Drug Therapy (Chemotherapy)