Vascular System Injuries

Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.

Also Known As:

Networked: 6501 relevant articles (248 outcomes, 594 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Inflammation (Inflammations)
2.	Hyperplasia
3.	Thrombosis (Thrombus)
4.	Hypertension (High Blood Pressure)
5.	Hemorrhage

Experts

1.	Touyz, Rhian M: 17 articles (01/2022 - 05/2003)
2.	Horiuchi, Masatsugu: 16 articles (01/2016 - 01/2002)
3.	Schiffrin, Ernesto L: 15 articles (01/2022 - 02/2003)
4.	Rasmussen, Todd E: 15 articles (01/2021 - 04/2005)
5.	Weber, Christian: 15 articles (01/2017 - 11/2003)
6.	Jiang, Hong: 14 articles (12/2020 - 11/2002)
7.	Brass, Lawrence F: 13 articles (01/2021 - 11/2002)
8.	Li, Wei: 12 articles (01/2022 - 05/2008)
9.	Paradis, Pierre: 12 articles (01/2022 - 03/2011)
10.	Robson, Simon C: 12 articles (03/2014 - 03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vascular System Injuries:

1.	Estrogens (Estrogen)FDA Link 01/01/2023 - "Estrogen protection against mechanical vascular injury was impaired in this model. " 08/01/2013 - "Many studies have shown that estrogen inhibits VSMC proliferation in response to vascular injury in the mouse carotid injury model. " 11/01/2008 - "Also, experimental studies have demonstrated beneficial effects of estrogen in improving vascular function and reducing vascular injury. " 06/04/2002 - "This study has characterized the expression of SRC-3 in cardiovascular tissue and the role of SRC-3 in estrogen-dependent vasoprotection from vascular injury. " 06/27/2000 - "Previous in vitro studies have suggested that estrogen attenuates the vascular injury response by modulating vascular smooth muscle cell (VSMC) expression of soluble factor(s) directing migration of adventitial fibroblasts. "
2.	Proteins (Proteins, Gene)FDA Link 02/01/2011 - "Immunoblotting results validated a significant reduction in these proteins in the plasma at 2 or 5 weeks after vascular injury, in comparison to control animals without vascular injury. " 07/01/2023 - "Animal studies indicated that Hom effectively upregulated the protein expression of p-AMPK and TFEB, enhanced autophagy, reduced apoptosis, and alleviated vascular injury. " 10/01/2019 - "In the present study, we examined the effect of RNA-binding motif protein 38 (Rbm38) during re-endothelialization in a murine model of experimental vascular injury. " 08/01/2012 - "In this study, we show that adenovirus-mediated overexpression of KLF5 increased neointimal formation, while human heart LIM protein (hhLIM) decreased neointimal formation following vascular injury. " 11/18/2011 - "Our proteomics study has identified Lp(a)-associated proteins that support a suggested role of Lp(a) in response to wounding which points to mechanisms of Lp(a) pathogenicity at sites of vascular injury and atherosclerotic lesions. "
3.	Retinaldehyde (Retinal)IBA 12/01/2022 - "We studied retinal vessels in a mouse model of neonatal HIE and the efficacy of 7,8-DHF in ameliorating HI-related retinal vascular injury. " 03/01/2015 - "Here, we test whether PEDF ameliorates retinal vascular injury induced by HETEs and the underlying mechanisms. " 08/05/2023 - "OCT-A seems to have potential diagnostic value in differentiating patients with PRP from patients with SSc and VEDOSS, and there is potential value in assessing prognostic roles, since findings from OCT-A images could be early indicators of retinal vascular injury long before overt SSc symptoms develop." 01/01/2021 - "OCTA analysis confirmed impairment of retinal and choroidal microperfusion in SSc patients, supporting the hypothesis of wide spreading vascular injury. " 01/01/2020 - "Afterward, the expression of miR-20b-3p and TXNIP, visual function, inflammatory factors, microvascular injury, vascular permeability, cell apoptosis, and angiogenesis in rats' retinal tissues were assessed. "
4.	CytokinesIBA 01/01/2013 - "They also exhibited a marked decrease in inflammatory cytokines, vascular injury markers, and neutrophil-associated inflammatory mediators. " 08/02/2021 - "In this study, we demonstrated that Re treatment significantly inhibited vascular injury-induced neointimal thickening, reduced the intimal area and intima/media (I/M) ratio, increased the lumen area, and inhibited pro-inflammatory cytokines. " 03/01/2019 - "Role of oxidative stress, angiogenesis and chemo-attractant cytokines in the pathogenesis of ischaemic protection induced by remote ischaemic conditioning: Study of a human model of ischaemia-reperfusion induced vascular injury." 08/15/2010 - "The data from these in vitro studies provide further evidence that cytokines and other vasoactive substances produced in macrophages potentially contribute to vascular injury in BTV-infected ruminants, along with direct effects of the virus itself on ECs." 10/01/2023 - "This article reviews previous findings about the pathophysiology of RT-induced vascular injury, including endothelial cell injury, oxidative stress, inflammatory cytokines, angiogenic pathways, and remodeling. "
5.	Hemostatics (Antihemorrhagics)IBA 01/01/2020 - "This is the first case of vascular injury managed specifically with only hemostatic matrix sealant agent described in literature and it has proven effective as well as the angiorrhaphy technique when it comes to small size artery lesions. " 10/01/2017 - "Unraveling the non-hemostatic role of endothelial vWF in the onset of endothelial dysfunction could provide new avenues for protection against vascular injury mediated by AngII." 10/23/2023 - "The objective of this study was to evaluate the hemostatic efficacy of pREBOA in a model of uncontrolled vascular injury. " 01/01/2023 - "This study aimed to compare next-generation hemostatic agents against the current military standard in a translational swine model of vascular injury and coagulopathy. " 06/01/2011 - "This study was conducted to compare and ascertain the hemostatic properties of SL and compare it with known hemostatic dressings: Combat Gauze® (CG) and WoundStat™ (WS) in a swine model with punch, vascular injury. "
6.	LipidsIBA 12/01/2022 - "ECFC-exosome treatment attenuated vascular endothelial injury, regulated lipid balance and activated autophagy in an atherogenic rat model of vascular injury, whereas these effects were eliminated with ECFC-exosomes with knockdown of miR-21-5p. " 09/01/2022 - "Both metabolomics analysis and network pharmacology results showed that IPTS ameliorates vascular injury and that lipid accumulation may be mediated by PI3K/AKT signaling pathway activation. " 12/01/2018 - "Our studies provide further support for the potential therapeutic role of specialized proresolving lipid mediators such as D-series resolvins in modulating vascular injury and repair." 01/19/2001 - "Biochemical and cell biology studies have defined multiple interactions of (.)NO with oxidizing lipids that could lead to either vascular protection or potentiation of inflammatory vascular injury. " 09/01/1998 - "Recent studies suggest that in addition to lowering plasma lipid levels, these drugs modify other factors that contribute to vascular injury. "
7.	AntioxidantsIBA 09/29/2022 - "Onion and Apple Functional Ingredients Intake Improves Antioxidant and Inflammatory Status and Vascular Injury in Obese Zucker Rats." 10/01/2018 - "Diabetes resulted in progressive alteration of redox balance in mice, as demonstrated by increased ROS levels and decreased antioxidant activity, which ultimately led to renal dysfunction and vascular injury. " 05/11/2011 - "The findings demonstrate that HT positively regulates the antioxidant defense system in VECs through the activation of Nrf2 followed by cell proliferation and resistance to vascular injury. " 03/27/2009 - "Thus, the mechanism for the accelerated vascular injury in older LDLR(-/-) mice was likely the profound inability to mount an antioxidant response. " 09/23/2008 - "Single antioxidant strategies to prevent vascular injury have met with mixed results. "
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/01/2013 - "Increased VEGF level in patients who showed no improvement with CSF drainage suggests that a possible greater ischemic or vascular injury may play a role in these patients. " 07/06/2023 - "The evaluation of vascular injury in DN has primarily focused on active molecules of VEGF, namely VEGFA and VEGF2(F2R). " 11/14/2022 - "Chronic aerobic exercise can effectively rescue the reduction of myocardial and circulating miR-126 and vascular endothelial growth factor (VEGF) in diabetic mice against diabetic vascular injury. " 01/01/2022 - "Vascular endothelial growth factor (VEGF) is a potent agonist of angiogenesis that induces proliferation and differentiation of endothelial progenitor cells (EPCs) after vascular injury. " 01/01/2020 - "Our results indicate that miR-126 protects against vascular injury by promoting CXCR4 expression and LOC homing via ERK/VEGF and Akt/eNOS signaling pathways and maintaining stemness via targeting KLF-8."
9.	EndotoxinsIBA 02/21/1997 - "Finally, 1400W was greater than 50-fold more potent against iNOS than eNOS in a rat model of endotoxin-induced vascular injury. " 01/01/1998 - "AT III prevented pulmonary vascular injury by inhibiting leukocyte activation in rats given endotoxin. " 12/01/1997 - "Since the increases in Ra, Kf and W/D weight ratio caused by endotoxin were blocked by pre-treatment with db-cAMP, agents that increase intracellular cAMP level may be useful to prevent acute pulmonary vascular injury." 09/01/1996 - "We have previously demonstrated that APC prevents endotoxin (ET)-induced pulmonary vascular injury by inhibiting activated leukocytes. " 06/01/1996 - "Pulmonary vascular injury was assessed 6 hrs after administration of endotoxin in terms of the increase in vascular permeability. "
10.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/01/2017 - "Statins will be less effective in attenuating IH after vascular injury in TSP-1-null (Thbs1-/-) mice compared with wild-type (WT) mice. " 05/01/2009 - "The radioprotective efficacy of GT3 against vascular injury is related to its properties as an HMG-CoA reductase inhibitor." 09/01/2008 - "Our results showed that statins retarded vascular injury and improved patient function. " 09/22/2023 - "Determine if irradiation causes chronic vascular injury and whether short-term administration of statins during and after irradiation is sufficient to prevent chronic injury compared to long-term administration. " 03/01/2018 - "Statins have significant immunomodulatory effects and reduce vascular injury. "

Therapies and Procedures

1.	Therapeutics 05/26/2009 - "These findings indicate that Notch1, rather than Notch3, mediates SMC proliferation and neointimal formation after vascular injury through CHF1/Hey2 and suggest that therapies that target Notch1/CHF1/Hey2 in SMCs may be beneficial in preventing vascular proliferative diseases." 02/01/2014 - "Recent advances in technology have resulted in endovascular therapy becoming a common first-line treatment, and interventional radiologists now play a major role in the management of these vascular injuries. " 07/01/2019 - "A staged approach of digital subtraction angiography and endovascular therapy followed by surgical treatment is a safe and effective management strategy for patients presenting with a retained transcranial knife and suspected vascular injury." 07/01/2019 - "These results suggested that DG improved diabetic vascular injury possibly by reducing oxidative stress, which provides scientific evidence for the application of DG for diabetic vascular therapy." 05/30/2023 - "Given the potentially devastating consequences of a missed BCVI, the addition of CTA to initial work-up may be worthwhile to evaluate for cervical vascular injury, but further studies into the outcomes of children who do receive prophylactic therapy are needed."
2.	Surgical Amputation (Amputations) 12/11/2009 - "Despite spontaneous resolution of the vascular insult, it is important to remember the association of such fractures with vascular injuries in order to diagnose them early and prevent serious complications including amputation." 12/01/2015 - "Only 38% of patients with extremity vascular injury or amputation received a C intervention, with a significant reduction in blood products and intravenous fluids associated with receiving a C PHI (both p < 0.05). " 10/01/1990 - "Progress in the management of complex vascular injuries of the limbs has not eliminated the necessity for amputations. " 05/01/1986 - "Progress in the management of complex vascular injuries of the extremities has not eliminated the necessity for amputation. " 10/01/2021 - "This study involved 199 patients presenting to 9 trauma centers with orthopaedic and vascular injuries resulting in ischemic limbs for whom the orthopaedic service was involved with the decision for salvage versus amputation. "
3.	Catheters 01/01/2019 - "Conventional catheter based angiography, however, remain the gold standard in the determination of vascular injury. " 01/01/2016 - "It has a lower device profile to reduce access-related vascular injury, an improved delivery catheter to facilitate accurate implantation, and incorporates an additional outer sealing cuff to minimize paravalvular leakage. " 05/01/2006 - "Although the reported sensitivity of computed tomographic angiography (CTA) for the diagnosis of blunt cervical vascular injury (BCVI) has been inadequate, we hypothesized that advances in computed tomographic technology have improved the diagnostic sensitivity of CTA at least to that of invasive catheter angiography (CA). " 12/01/2006 - "Blood vessels are easily accessible for the delivery of the gene product, and experimental studies using animal models have used catheter-delivered gene products at the site of vascular injury. " 07/01/1993 - "Recent studies in which animals were bled from a vascular injury rather than an intravascular catheter demonstrate increased blood loss and mortality with rapid volume expansion. "
4.	Resuscitation 07/01/1980 - "Greater civilian use of firearms and improved transportation and resuscitation of the injured have provided our institutions with an increasing experience with subclavian vascular injuries. " 01/01/2023 - "Patients with BSI who arrived hypotensive and were refractory to resuscitation required surgery and patients with vascular injury on abdominal computed tomography were considered for SAE. " 01/01/2020 - "Resuscitation and close monitoring prior to and during surgery are vital with anticipation of major organ and vascular injuries. " 01/01/2020 - "Resuscitation and close monitoring prior to and during surgery are vital with anticipation of major organ and vascular injuries. " 11/01/2019 - "An analysis of the vascular injuries and attempted resuscitation surrounding the assassination of Martin Luther King Jr."
5.	Stents 02/01/2014 - "Augmented systemic or local levels of HSP27 markedly improved RE after vascular injury, an effect that is of particular relevance to the safety profile of vascular stents." 04/15/2015 - "In conclusion, the use of self-expanding covered stents is safe and effective in case of TF-TAVI-induced vascular injury, with good short- and medium-term outcomes. " 01/01/2021 - "In this study, we examine the hypothesis that vascular injury is predictable from stent design and that the expanding force of stent deployment results in increased circumferential stress in the arterial tissue, which may explain acute injury poststent deployment. " 12/01/2015 - "The objective of this study was to evaluate the feasibility, stent deployment time (SDT), and stent patency of this technique in a ewe vascular injury model. " 04/09/1998 - "Initially, studies of endovascular implants such as stents focused on developing models of vascular injury. "