Cystine-Knot Miniproteins

A structurally-related family of small proteins that form a stable tertiary fold pattern which is supported by a series of disulfide bonds. The arrangement of disulfide bonds between the CYSTEINE moieties results in a knotted structure which is unique to this family of proteins.

Also Known As:

Networked: 29 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cochran, Jennifer R: 16 articles (10/2016 - 03/2009)
2.	Kimura, Richard H: 13 articles (10/2019 - 03/2009)
3.	Cheng, Zhen: 10 articles (10/2019 - 03/2009)
4.	Miao, Zheng: 6 articles (11/2014 - 12/2009)
5.	Gambhir, Sanjiv Sam: 5 articles (12/2022 - 03/2009)
6.	Gambhir, Sanjiv S: 5 articles (10/2019 - 03/2010)
7.	Jiang, Lei: 5 articles (06/2015 - 12/2009)
8.	Shen, Bin: 3 articles (12/2022 - 11/2014)
9.	Kintzing, James R: 3 articles (10/2016 - 01/2016)
10.	Liu, Hongguang: 3 articles (04/2011 - 12/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Targeting the tumor vasculature with engineered cystine-knot miniproteins." 01/14/2015 - "A chemical-based dimerization strategy was critical, as knottin dimers created through genetic fusion to a bivalent antibody domain exhibited only modest improvement (less than 5-fold) in tumor cell binding relative to the knottin monomer. " 11/03/2014 - "(18)F-FP-3-4A is a highly promising knottin based PET probe for translating into clinical imaging of tumor angiogenesis. " 01/01/2011 - "The aim of the current study was to evaluate tumor uptake and in vivo biodistribution of (18)F-labeled knottins in a U87MG glioblastoma model. " 12/01/2022 - "Knottin PET/CT detected all known pancreatic tumors in the 15 patients, although it did not detect small peri-pancreatic lymph nodes of less than 1 cm in short diameter in two of three patients who had lymph node metastases at surgery. "
2.	Glioblastoma (Glioblastoma Multiforme) 01/01/2011 - "The aim of the current study was to evaluate tumor uptake and in vivo biodistribution of (18)F-labeled knottins in a U87MG glioblastoma model. " 01/01/2013 - "Integrin-binding AgTx, AgRP, and EETI knottins all generated high tumor imaging contrast in U87MG glioblastoma xenograft models. " 12/01/2009 - "The binding affinities of unlabeled knottin peptide 2.5D and 19F-FB-2.5D to U87MG glioblastoma cells were measured by competition binding assay using 125I-labeled echistatin. " 11/01/2009 - "Select peptides were synthesized and were shown to compete for natural ligand binding to integrin receptors expressed on the surface of U87MG glioblastoma cells with half-maximal inhibitory concentration values of 10-30 nM. Receptor specificity assays demonstrated that engineered knottin peptides bind to both alpha(v)beta(3) and alpha(v)beta(5) integrins with high affinity. "
3.	Atherosclerotic Plaque (Atheroma) 06/01/2015 - "In this study, an engineered integrin αvβ3-targeting PET probe, (64)Cu-NOTA-3-4A, derived from a divalent knottin miniprotein was evaluated in a mouse model for carotid atherosclerotic plaques. "
4.	Chronic Pain 10/01/2016 - "Naturally occurring knottins are clinically approved for treating chronic pain and GI disorders. " 10/29/2019 - "The exquisite inhibitory properties of spider knottins over key NaV subtypes make them the best lead molecules for the development of novel analgesics to treat chronic pain." 10/01/2014 - "Several naturally-occurring knottins have recently received approval for treating chronic pain and irritable bowel syndrome, while others are under development for tumor imaging applications. "
5.	Pain (Aches) 01/01/2023 - "Excelsatoxin A (ExTxA), a pain-causing knottin peptide from the Australian stinging tree Dendrocnide excelsa, is the first reported plant-derived NaV channel modulating peptide toxin. " 10/29/2019 - "Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways." 10/17/2018 - "Here, we use chemoenzymatic ligation to produce double-knottins to probe the effect of bivalent modulation on the voltage-gated sodium channel subtype 1.7 (NaV1.7), which is implicated in pain signaling. "

Related Drugs and Biologics

1.	Integrins
2.	Peptides (Polypeptides)
3.	Spider Venoms (Venom, Spider)
4.	CY5.5 cyanine dye
5.	Cystine-Knot Miniproteins
6.	Proteins (Proteins, Gene)
7.	Cystine (L-Cystine)
8.	Voltage-Gated Sodium Channels
9.	Vitronectin
10.	Extracellular Matrix Proteins

Related Therapies and Procedures

1.	Therapeutics
2.	Microbubbles
3.	Ligation