Kashin-Beck Disease

Disabling osteochondrodysplasia with OSTEOSCLEROSIS, cone-shaped METAPHYSIS, and shortening of the DIAPHYSIS. It is endemic in parts of Siberia and northern China. Mineral deficiencies (e.g., selenium, iodine), fungal cereal contamination, and water contamination may be contributing factors in its etiology.

Also Known As:

Networked: 250 relevant articles (9 outcomes, 65 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Knee Osteoarthritis
2.	Osteoarthritis
3.	Pain (Aches)
4.	Keshan disease
5.	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)

Experts

1.	Guo, Xiong: 72 articles (10/2022 - 01/2006)
2.	Wang, Xi: 19 articles (10/2022 - 07/2015)
3.	Han, Jing: 15 articles (10/2022 - 09/2012)
4.	Lammi, Mikko J: 15 articles (06/2022 - 04/2008)
5.	Zhang, Feng: 15 articles (01/2022 - 07/2012)
6.	Ning, Yujie: 15 articles (01/2022 - 02/2013)
7.	Wu, Cuiyan: 12 articles (10/2022 - 09/2012)
8.	Chen, Jinghong: 12 articles (01/2022 - 02/2009)
9.	Yang, Lei: 12 articles (01/2022 - 03/2016)
10.	Wang, Sen: 11 articles (04/2022 - 02/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Kashin-Beck Disease:

1.	SeleniumIBA 07/01/2003 - "The results of this study do not rule out the possibility that selenium may help to prevent the occurrence of Kashin-Beck disease. " 11/02/2023 - "A Metabolomics Study of Feces Revealed That a Disturbance of Selenium-Centered Metabolic Bioprocess Was Involved in Kashin-Beck Disease, an Osteoarthropathy Endemic to China." 10/15/2017 - "In the present study, we investigated the expression of ERK and JNK signal molecular, as well as nuclear factor-ĸB in the pathogenesis of Kashin-Beck disease, evaluated the effect of selenium on ERK signal pathway. " 11/01/2015 - "Previous studies have shown that the selenium (Se) deficiency is an important factor for the etiology of Kashin-Beck disease (KBD). " 02/01/2009 - "We searched eight electronic databases and seven journals (upto July 2007) to identify randomized controlled trials (RCTs) and prospective non-RCTs comparing selenium supplementations with placebo or no intervention for preventing Kashin-Beck disease (KBD). "
2.	Hyaluronic Acid (Hyaluronan)IBA 01/01/2015 - "The long-term efficacy and tolerability of hyaluronic acid in adult patients with Kashin-Beck disease of the knee." 06/01/2014 - "To assess the efficacy and safety of intra-articular hyaluronic acid (IAHA) injection in knee joints of patients with Kashin-Beck disease (KBD). " 03/01/2019 - "Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee." 08/01/2016 - "The aim of the present study was to determine whether hyaluronic acid (HA) or physical therapy agents (PTA) can improve functional parameters in patients with knee Kashin-Beck disease (KBD). " 08/01/2016 - "The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study."
3.	Glucosamine (Dona)IBA 05/01/2016 - "Hyaluronic acid and glucosamine sulfate for adult Kashin-Beck disease: a cluster-randomized, placebo-controlled study." 07/01/2012 - "Chondroitin sulfate and/or glucosamine hydrochloride for Kashin-Beck disease: a cluster-randomized, placebo-controlled study." 05/01/2016 - "To evaluate the efficacy and safety of hyaluronic acid (HA) and glucosamine sulfate (GS) in alleviating symptoms and improving function of Kashin-Beck disease (KBD). " 07/01/2012 - "To evaluate the efficacy and safety of chondroitin sulfate and/or glucosamine hydrochloride in alleviating symptoms and improving the dysfunction of Kashin-Beck disease (KBD) patients. " 01/01/2012 - "The objective of the study was to identify adults with symptomatic Kashin-Beck disease (KBD) and observe the efficacy and safety of diclofenac sodium, naproxen, and glucosamine hydrochloride in these adult patients in Rang-tang (Sichuan Province), China. "
4.	IodineIBA 01/01/2001 - "The percentages of low urinary iodine concentration were significantly greater in the subjects with Kashin-Beck disease. " 01/01/2001 - "Kashin-Beck disease and iodine deficiency in Tibet." 10/15/1998 - "Kashin-Beck disease--expanding the spectrum of iodine-deficiency disorders." 10/15/1998 - " Mean urinary iodine concentration was lower in subjects with Kashin-Beck disease than in control subjects and hypothyroidism was more frequent. " 10/15/1998 - "The mean urinary iodine concentration was lower in subjects with Kashin-Beck disease than in control subjects (1.2 vs. 1.8 microg per deciliter [94 vs. 142 nmol per liter], P<0.001) and hypothyroidism was more frequent (23 percent vs. 4 percent, P=0.01). "
5.	Sodium SeleniteIBA 07/01/2012 - "Sodium selenite for treatment of Kashin-Beck disease in children: a systematic review of randomised controlled trials." 07/01/2012 - "To assess the effectiveness and safety of sodium selenite in treatment of patients with Kashin-Beck disease (KBD). " 01/01/2016 - "We examined the expression levels of JNK in Kashin-Beck disease (KBD) patients, tested the potential protective effects of sodium selenite on tert-butyl hydroperoxide (tBHP)-induced oxidative injury and apoptosis in human chondrocytes as well as its underlying mechanism in this study. " 01/01/2016 - "Effects of sodium selenite on c-Jun N-terminal kinase signalling pathway induced by oxidative stress in human chondrocytes and c-Jun N-terminal kinase expression in patients with Kashin-Beck disease, an endemic osteoarthritis." 05/01/1986 - "The effect of sodium selenite on DNA and sulfated proteoglycan synthesis by cultured rabbit articular and growth plate chondrocytes was studied as an in vitro model for Kashin-Beck disease. "
6.	Meloxicam (Mobic)FDA LinkGeneric 07/01/2012 - "A randomized, single-blind comparison of the efficacy and tolerability of hyaluronate acid and meloxicam in adult patients with Kashin-Beck disease of the knee." 07/01/2012 - "The aim of this study was to prospectively evaluate the efficacy and tolerability of hyaluronic acid (HA) and meloxicam for the treatment of knee pain due to Kashin-Beck disease (KBD). " 09/01/2011 - "Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients." 09/01/2011 - "The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck disease. " 09/01/2011 - "Adults (n = 168) with Kashin-Beck disease were randomised in clusters to receive six week courses of celecoxib 200 mg once daily, meloxicam 7.5 mg once daily or paracetamol 300 mg three times daily. "
7.	fulvic acidIBA 02/01/1993 - "High concentrations of fulvic acid and selenium deficiency are the main causative factors of Kashin-Beck disease, an endemic, chronic and degenerative osteoarticular disorder found in China. " 12/18/1991 - "Accordingly, one may assume that the impaired conversion of pro-pN-collagen II to collagen II and the structural alteration of collagen II, presumably caused by fulvic acid and other environmental factors, play an important role in the pathogenesis of Kashin-Beck disease." 12/18/1991 - "Fulvic acid disturbs processing of procollagen II in articular cartilage of embryonic chicken and may also cause Kashin-Beck disease." 01/01/1993 - "Selenium deficiency and fulvic acid supplementation induces fibrosis of cartilage and disturbs subchondral ossification in knee joints of mice: an animal model study of Kashin-Beck disease." 09/01/1997 - "In order to investigate the effect of ginger on Kashin-Beck disease (KBD), the ginger volatile oil was taken as a scavenger and proved effective in inhibiting the production of hydrogen peroxide in chondrocytes induced by fulvic acid from KBD area."
8.	ChondroitinIBA 10/01/2013 - "Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin-Beck disease and primary osteoarthritis." 12/01/2019 - " Points• There were 23 nutraceuticals, pharmaceuticals and surgical and complementary treatments assessed for Kashin-Beck disease (KBD) in randomised trials.• Among the 23 treatments, chondroitin, glucosamine, IAH and non-steroid anti-inflammatory drugs are more effective than placebo to relieve symptoms for adults with KBD.• Selenium supplement is more effective than placebo for radiographic improvement in children or adolescents.• The efficacy of surgeries, aspirin, vitamin C and complementary treatments for KBD has not been established yet."
9.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 02/01/1992 - "Thus, FA and the mycotoxin, which are seen as exogenous free-radical carriers, are important environmental factors in the pathogenesis of Kashin-Beck disease; and selenium, vitamin C, and vitamin E, which inhibit free-radical formation, are considered to be protective." 12/01/2019 - " Points• There were 23 nutraceuticals, pharmaceuticals and surgical and complementary treatments assessed for Kashin-Beck disease (KBD) in randomised trials.• Among the 23 treatments, chondroitin, glucosamine, IAH and non-steroid anti-inflammatory drugs are more effective than placebo to relieve symptoms for adults with KBD.• Selenium supplement is more effective than placebo for radiographic improvement in children or adolescents.• The efficacy of surgeries, aspirin, vitamin C and complementary treatments for KBD has not been established yet."
10.	tert-ButylhydroperoxideIBA 01/01/2016 - "We examined the expression levels of JNK in Kashin-Beck disease (KBD) patients, tested the potential protective effects of sodium selenite on tert-butyl hydroperoxide (tBHP)-induced oxidative injury and apoptosis in human chondrocytes as well as its underlying mechanism in this study. "

Therapies and Procedures

1.	Debridement 10/01/2021 - "Long-term outcomes of arthroscopic debridement of the knee in adults with Kashin-Beck disease: an 18-year follow-up." 09/01/2015 - "Long-Term Efficacy of Arthroscopic Debridement on Knee Osteoarthritis in Patients with Kashin-Beck Disease."
2.	Injections 03/01/2019 - "Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee." 03/01/2019 - "To prospectively evaluate the long-term efficacy and safety of repeated sodium hyaluronate injections for the treatment of knee pain due to Kashin-Beck disease (KBD). "
3.	Knee Replacement Arthroplasty (Total Knee Replacement) 04/01/2014 - "This study aimed to prospectively determine the functional outcomes of total knee arthroplasty (TKA) in adult patients with severe Kashin-Beck disease (KBD) of the knee. " 04/01/2014 - "Total knee arthroplasty in elderly patients with severe Kashin-Beck disease of the knee." 06/01/2017 - "This study reported two cases of patients with Grade III Kashin-Beck disease (KBD) with skeletal dysplasia concomitant with complex knee deformity and functional limitation treated by staged total knee arthroplasty (TKA). " 01/01/2022 - "Patients with Kashin-Beck Disease Obtained Lower Functional Activities but Better Satisfaction Than Patients with Osteoarthritis After Total Knee Arthroplasty: A Retrospective Study." 12/01/2020 - "Comment on Liu et al.: a comparative study of clinical effect of total knee arthroplasty in the treatment of primary osteoarthritis and osteoarthritis of Kashin-Beck disease."
4.	Physical Therapy Modalities (Physical Therapy Technique) 01/01/2001 - "One-hundred and thirty-five patients with Kashin-Beck disease were allocated to either physical therapy (72 patients) or prescription of multivitamins (63 patients). " 01/01/2001 - "A clinical trial of physical therapy treatment for patients suffering from Kashin-Beck disease (KBD) has been carried out in Tibet. " 01/01/2001 - "Effects of physical therapy on patients with Kashin-Beck disease in Tibet." 08/01/2016 - "The aim of the present study was to determine whether hyaluronic acid (HA) or physical therapy agents (PTA) can improve functional parameters in patients with knee Kashin-Beck disease (KBD). " 08/01/2016 - "The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study."
5.	Lasers (Laser) 01/01/2008 - "Detection of serum proteomic changes and discovery of serum biomarkers for Kashin-Beck disease using surface-enhanced laser desorption ionization mass spectrometry (SELDI-TOF MS)." 01/01/2008 - "The purpose of the current study was to investigate the changes of serum proteome and discover potential biomarkers for Kashin-Beck disease (KBD) using surface-enhanced laser desorption ionization mass spectrometry (SELDI-TOF MS). "