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Frontotemporal Lobar Degeneration (Semantic Dementia)

Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.
Also Known As:
Semantic Dementia; Degeneration, Frontotemporal Lobar; Dementia, Semantic; FTLD; Degenerations, Frontotemporal Lobar; Dementias, Semantic; FTLDs; Frontotemporal Lobar Degenerations; Lobar Degeneration, Frontotemporal; Lobar Degenerations, Frontotemporal; Semantic Dementias
Networked: 1012 relevant articles (19 outcomes, 90 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Frontotemporal Lobar Degeneration (Semantic Dementia)
2. Alzheimer Disease (Alzheimer's Disease)
3. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
4. Neurodegenerative Diseases (Neurodegenerative Disease)
5. Dementia (Dementias)

Experts

1. Trojanowski, John Q: 80 articles (01/2016 - 05/2005)
2. Dickson, Dennis W: 66 articles (10/2015 - 05/2005)
3. Lee, Virginia M-Y: 55 articles (01/2016 - 06/2006)
4. Rademakers, Rosa: 54 articles (10/2015 - 03/2006)
5. Grossman, Murray: 45 articles (01/2016 - 12/2005)
6. Neumann, Manuela: 43 articles (07/2015 - 06/2005)
7. Hasegawa, Masato: 40 articles (08/2015 - 12/2006)
8. Miller, Bruce L: 38 articles (02/2016 - 03/2004)
9. Arai, Tetsuaki: 37 articles (02/2015 - 12/2006)
10. Akiyama, Haruhiko: 37 articles (02/2015 - 12/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Frontotemporal Lobar Degeneration:
1. protein TDP-43 (TDP-43)IBA
2. UbiquitinIBA
3. DNA-Binding Proteins (DNA Binding Protein)IBA
4. Biological Markers (Surrogate Marker)IBA
5. AntibodiesIBA
6. Protein Isoforms (Isoforms)IBA
7. Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
8. pemetrexed (MTA)FDA Link
9. Fluvoxamine (Luvox)FDA LinkGeneric
10. polyglutamineIBA

Therapies and Procedures

1. Therapeutics
2. Aftercare (After-Treatment)
3. Activities of Daily Living (ADL)
4. Ligation
5. Intravenous Injections