Claudins

06/01/2020 - "Previous clinical trials have revealed improved anti-tumor activity in patients treated with an anti-claudin antibody by investigating the expression of claudin 18.2 in tumor cells. "
08/22/2023 - "Recent studies have highlighted the role of claudins' expression in tumors throughout the body, and their prognostic and therapeutic role. "
07/19/2023 - "The groups of claudin-low and claudin-non-suppressed breast cancers from the extensive publicly available genomic cohorts of the METABRIC study were examined to delineate and compare their molecular landscape. "
01/01/2023 - "In addition, some studies have confirmed the role of some claudin proteins in the diagnosis and treatment of pancreatic tumors. "
09/01/2021 - "Studies on expression alterations of claudins have revealed a range of outcomes that reflect the complexity of claudins in terms of spatial localization, tumor type and stage of disease. "

01/01/2023 - "According to a clinical retrospective analysis, claudin-low breast cancer can achieve low pathological complete remission. "
09/25/2014 - "Our results uncover crosstalk between NFκB and GLI1 signals and suggest that targeting these pathways may be effective against the claudin-low breast cancer subtype."
01/01/2023 - "At present, although several therapeutic targets of claudin-low breast cancer have been identified, the effective treatment remains in basic research stages, and no animal studies or clinical trials have been designed. "
01/01/2022 - "This study integrated Spatial Transcriptomics (ST) with immunofluorescence to demonstrate their spatial distribution in human claudin-low breast cancer MDA-MB-231 engraft. "
01/01/2022 - "This study aimed to investigate the functional role of claudin 19 (CLDN19) in human breast cancer progression. "

11/16/2023 - "Claudin 18.2 has emerged as a promising therapeutic target in gastric cancer based on phase 3 studies. "
11/16/2023 - "In conclusion, claudin 18.2 was overexpressed in almost half of resectable gastric cancer patients. "
11/16/2023 - "Claudin 18.2 overexpression was also associated with Borrmann type 4 among patients with advanced gastric cancer and the diffuse histological type. "
11/16/2023 - "However, clinicopathologic features associated with claudin 18.2 overexpression have not been comprehensively studied specifically for patients with resectable gastric cancer. "
11/16/2023 - "Clinicopathologic features and prognostic value of claudin 18.2 overexpression in patients with resectable gastric cancer."

02/15/2023 - "Dysfunction of TJs and their components, especially claudins, have a significant role in the pathogenesis and vicious circle of inflammation in AD. "
06/03/2022 - "Meanwhile, the cerebral inflammation and cell apoptosis in claudin-5a-/- were assessed by live imaging of transgenic zebrafish, RT-qPCR, IF, and TUNEL assay. "
11/01/2021 - "Alterations to claudin proteins may reflect changes seen to intestinal permeability and inflammation in the context of NEC. "
11/01/2021 - "Claudin proteins appear to have a role in the stability of the gut epithelium through the regulation of intestinal permeability, maturity, and inflammation. "
01/01/2017 - "Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation."

01/01/2014 - "Thus, this claudin may be helpful in differentiating metastatic carcinoma from reactive mesothelial cells in pleural and peritoneal fluid cytology specimen."
01/01/2018 - "In this study, the nanoscale poroelasticity of human mammary basal/claudin low carcinoma cell (MDA-MB-231) was investigated using indentation-based atomic force microscopy. "
07/01/2007 - "The aim of the study was to elucidate the significance of claudins in surgically treated esophageal carcinoma. "
08/22/2023 - "In this review, we survey the available literature describing the aberrant expression of various claudins in carcinomas in this region, while highlighting their potential prognostic and therapeutic value. "
08/22/2023 - "Aberrant Expression of Claudins in Head and Neck Carcinomas and Their Prognostic and Therapeutic Value: A Narrative Review."