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Single-Chain Antibodies

A form of antibodies consisting only of the variable regions of the heavy and light chains, connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
Also Known As:
ScFv Antibodies; Single-Chain Fv; Single-Chain Fv Antibody; Single-Chain Variable Fragment; Single-Chain Variable Fragment Antibodies; Single-Chain Variable Fragment Antibody; Single-Chain Variable Fragments; Antibodies, ScFv; Antibodies, Single-Chain; Antibody, Single-Chain Fv; Fragment, Single-Chain Variable; Fragments, Single-Chain Variable; Fv Antibody, Single-Chain; Fv, Single-Chain; Single Chain Antibodies; Single Chain Fv; Single Chain Fv Antibody; Single Chain Variable Fragment; Single Chain Variable Fragment Antibodies; Single Chain Variable Fragment Antibody; Single Chain Variable Fragments; Variable Fragment, Single-Chain; Variable Fragments, Single-Chain
Networked: 538 relevant articles (25 outcomes, 53 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Marks, James D: 8 articles (01/2012 - 01/2004)
2. Liu, Bin: 7 articles (07/2010 - 01/2004)
3. Rosenblum, Michael G: 6 articles (01/2012 - 05/2006)
4. Marks, J D: 6 articles (08/2005 - 05/2000)
5. Kuroki, Masahide: 5 articles (08/2014 - 03/2002)
6. Deyev, Sergey M: 5 articles (01/2013 - 01/2008)
7. Adams, Gregory P: 5 articles (01/2012 - 03/2006)
8. Chester, Kerry A: 5 articles (02/2010 - 01/2002)
9. Kufer, Peter: 5 articles (05/2009 - 04/2005)
10. Baeuerle, Patrick A: 5 articles (05/2009 - 04/2005)

Related Diseases

1. Neoplasms (Cancer)
2. Hodgkin Disease (Hodgkin's Disease)
3. Residual Neoplasm
4. Breast Neoplasms (Breast Cancer)
5. Melanoma (Melanoma, Malignant)

Related Drugs and Biologics

1. Antibodies
2. Single-Chain Antibodies
3. Immunoglobulin G (IgG)
4. Streptavidin
5. Antigens
6. Immunotoxins (Immunotoxin)
7. DNA (Deoxyribonucleic Acid)
8. Glycoproteins (Glycoprotein)
9. Monoclonal Antibodies
10. Epidermal Growth Factor Receptor (EGF Receptor)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Radioimmunotherapy
3. Ligation
4. Gamma Cameras (Gamma Camera)
5. Immunotherapy