Corneal Perforation

01/01/2023 - "Retrocorneal scleral patch supported cyanoacrylate is effective for corneal perforation with corneo-scleral melt."
09/01/2006 - "Cyanoacrylate glue is an effective and safe method for sealing small corneal perforations. "
11/01/2023 - "Cyanoacrylate glue was applied to treat corneal perforations. "
01/27/2023 - "The corneal perforation was managed with cyanoacrylate glueing, followed by a local conjunctival flap. "
01/01/2023 - "Cyanoacrylate glue is chiefly used as a corneal patch to manage acute corneal perforations and improve visual outcomes. "

03/01/2014 - "Intracameral fibrin glue may be effective in the closure of corneal perforations."
01/01/2016 - "Taken together, the corneal stromal equivalent with SMILE-derived lenticules and fibrin glue appears to be a safe and effective alternative for the repair of damage to the anterior cornea, which may provide new avenues in the treatment of deep corneal defects or corneal perforations."
09/01/2007 - "To describe fibrin glue manufacture, development of a device to test the glued perforated corneal area resistance, subsequent experimental investigations of the use of the fibrin glue in corneal perforations, reporting its efficacy, mechanical resistance experiments and histological study. "
01/01/2018 - "The average referral distance was 217 miles and the median number of follow-up visits within 6 months was 4. The combination of a modified conjunctival flap, AMT, fibrin glue, and a BCL could provide a temporary method to stabilize and secure the integrity of the globe as well as the ocular surface after a nontraumatic acute corneal perforation. "
03/01/2014 - "[Intracameral fibrin glue in spontaneous corneal perforation]."

01/01/2020 - "This study was conducted to characterize morphological and functional outcome of application of tissue adhesive (TA) in corneal perforations. "
05/01/1983 - "To study the effect of the introduction of tissue adhesive to The Wilmer Institute in 1974, the records of 104 consecutive non-traumatic corneal perforations or descemetoceles admitted to The Wilmer Institute from 1960 to 1980 were assessed retrospectively with follow-up being obtained from records or from referral physicians for 87 of these perforations. "
01/01/2023 - "The present review focuses on the two main types of tissue adhesives, their applications in the management of corneal perforations, the associated complications, safety and efficacy data related to their use available in the literature and the need for newer adhesives in this field."
01/01/2023 - "Tissue Adhesives for the Management of Corneal Perforations and Challenging Corneal Conditions."
01/01/2022 - "In the last few years, the use of tissue adhesives in corneal perforation has gained immense popularity in clinical practices. "

01/01/1989 - "Use of steroids decreased the incidence of recurrent erosions and corneal perforations. "
10/01/2019 - "Corneal perforation following inappropriate long-term aggressive use of topical steroid."
01/01/2011 - "Multiple corneal ulcerations coupled with use of topical steroids may result in corneal perforation and formation of anterior staphyloma."
01/01/2021 - "We anticipate that both adjunctive topical steroids and CXL will improved best spectacle corrected visual acuity and also reduce complications such as corneal perforation and the need for therapeutic penetrating keratoplasty. "
02/01/2003 - "The response to surgical procedure and intravenous steroid treatment was poor and corneal perforation occurred. "

07/01/2011 - "Furthermore, we also used agonistic anti-mTREM-1 antibody to activate TREM-1 signaling in B6 mice and found that TREM-1 activation resulted in worsened disease and earlier corneal perforation in infected B6 mouse corneas and elevated production of proinflammatory cytokines and TLR signaling molecules but reduced expression of mBD2, SIGIRR, and ST2. "
07/01/2015 - "Desiccating stress worsens outcome of ocular AB, creating a cytokine and protease storm with greater neutrophil infiltration, increasing the risk of corneal perforation."
01/15/2007 - "Vasoactive intestinal peptide balances pro- and anti-inflammatory cytokines in the Pseudomonas aeruginosa-infected cornea and protects against corneal perforation."
02/01/2007 - "The SP antagonist Spantide provides a novel approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea of B6 mice, leading to a significant reduction in corneal perforation and improved disease outcome."
02/01/2007 - "Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection."

01/01/2015 - "The aim of this study was to test the use of BioCornea, a fish scale-derived collagen matrix for sealing full-thickness corneal perforations in mini-pigs. "
10/01/2020 - "Despite the potential of a collagen construct, consisting of a major extracellular matrix component of the native cornea, as a patch graft to treat the corneal perforation, there has still been difficulty in acquiring sufficient mechanical properties for clinical availability. "
10/01/2020 - "Ultra-stiff compressed collagen for corneal perforation patch graft realized by in situ photochemical crosslinking."
01/01/2012 - "In collagen cross-linking treatment group, one rabbit showed corneal melting after injury 23 days, without corneal perforation; corneal dissolution rate between the two groups was significantly different (P <0.05). "
10/01/2020 - "With sufficient mechanical strength for surgical suture and the controllable thickness for patient specificity, the potential of the fabricated IPC-compressed collagen construct for clinical applications was demonstrated by using an in vivo rabbit corneal perforation model. "

12/01/2016 - "Overall, no difference in the rate of corneal perforation or the need for TPK was determined for oral voriconazole vs placebo (hazard ratio, 0.82; 95% CI, 0.57-1.18; P = .29). "
11/01/2007 - "Fungal cultures of corneal scrapings revealed growth of Scedosporium apiospermum, a strain for which the main antifungals showed high minimal inhibitory concentrations (MICs), whereas the MIC of voriconazole was 0.125 microg/mL. Despite some improvement with topical 1% voriconazole and oral voriconazole (200 mg/day) treatment, a therapeutic penetrating keratoplasty was performed because of the high risk of corneal perforation. "
06/01/2010 - "Corneal perforations in the voriconazole group (10 of 60 patients) were not significantly different than in the natamycin-treated group (9 of 60 patients) (P >.99). "
04/09/2015 - "On average, people randomised to natamycin had better spectacle-corrected visual acuity at two to three months compared to people randomised to voriconazole but the estimate was uncertain and the 95% confidence intervals included 0 (no difference) (mean difference -0.12 logMAR, 95% CI -0.31 to 0.06, 434 participants; 3 studies, low quality evidence) and a decreased risk of corneal perforation or therapeutic penetrating keratoplasty, or both (RR 0.61; 95% CI 0.40 to 0.94, 434 participants, high quality evidence). "
05/01/2012 - "Despite aggressive antifungal therapy with voriconazole and amphotericin B, she required penetrating keratoplasty for impending corneal perforation. "

06/01/2013 - "The combined use of autologous fibrin membrane and E-PRP clot is a safe and effective surgical alternative for the closure of corneal perforations. "
06/01/2013 - "The combined use of autologous fibrin membrane and the eye platelet-rich plasma (E-PRP) clot could be considered as a new surgical alternative for the closure of corneal perforations. "
05/01/2009 - "Intracameral fibrin tissue sealant as an adjunct in tectonic lamellar keratoplasty for large corneal perforations."
07/01/2015 - "PRP for ophthalmologic use (E-PRP) has achieved successful outcomes as reported in the peer-review literature in the treatment of dry eye, post-laser in-situ keratomileusis ocular surface syndrome, dormant ulcers, and for ocular surface surgical reconstruction after corneal perforation associated to amniotic membrane transplantation, bovine pericardium membrane transplantation, or autologous fibrin membrane combined with solid PRP clot. "
06/01/2013 - "Nylon stitches were used to fixate the fibrin membrane to the conjunctiva and then the E-PRP clot was placed over the corneal perforation, underneath the fibrin membrane. "

02/01/2007 - "The SP antagonist Spantide provides a novel approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea of B6 mice, leading to a significant reduction in corneal perforation and improved disease outcome."
04/01/2008 - "Studies have shown that blocking substance P (SP) binding to neurokinin 1 receptor with spantide I prevents Pseudomonas aeruginosa-induced corneal perforation in susceptible C57BL/6 mice. "
02/01/2007 - "Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection."

01/01/2016 - "Corneal perforation secondary to a bird injury can be treated successfully with surgical closure and broad intravenous antibiotic coverage. "
11/01/2014 - "Furthermore, there was no evidence of difference in the risk of corneal perforation with any included antibiotics or antibiotic classes. "
01/01/2013 - "A 42-year-old man from Ghana presented with bilateral painful corneal perforations following ingestion of a sulphur-based antibiotic. "
01/01/1997 - "Treatment with local antibiotics was initiated but the condition of the eye worsened, ultimately resulting in corneal perforation. "
01/01/2017 - "Inappropriate or non-optimal antibiotic chemotherapy can lead to corneal perforation and rapid sight loss. "

01/01/2016 - "Multilayer amniotic membrane transplantation (AMT) was performed to seal the corneal perforation, which was effective for a short period. "
08/01/2004 - "To determine if multilayer amniotic membrane transplantation (AMT) is useful in the treatment of corneal perforations, and in particular to assess to what extent efficacy is affected by perforation size. "
12/01/2001 - "To evaluate the efficacy of amniotic membrane transplantation (AMT) in persistent corneal epithelial defect with or without stromal thinning and corneal perforation. "
01/01/2022 - "This study aimed to evaluate the effectiveness of combined UCP grafting and human amniotic membrane (HAM) transplantation for the management of corneal perforation or descemetocele. "
06/01/2014 - "This study included 6 eyes from 6 patients with corneal perforation who had received AM transplantation between May 2011 and April 2012. "

08/01/2004 - "These results suggest that multilayer AMT is effective for treating corneal perforations with diameter less than 1.5 mm. The technique may be a good alternative to penetrating keratoplasty, especially in acute cases in which graft rejection risk is high."
07/01/2009 - "Small-diameter penetrating keratoplasty seems to be effective in treating various eccentric corneal perforations. "
01/01/2017 - "The primary outcome of the trial was the rate of corneal perforation or the need for therapeutic penetrating keratoplasty. "
12/01/2016 - "The primary outcome of the trial was rate of corneal perforation or the need for therapeutic penetrating keratoplasty (TPK) within 3 months. "
10/27/2023 - "DALK combined with intralamellar tectonic patch graft may serve as a secure and effective alternative in treating frank corneal perforation, with reduced complications compared to conventional penetrating keratoplasty."

04/01/2023 - "Double lamellar keratoplasty presents a new therapeutic option for patients undergoing corneal perforation, and it provides improvement in visual acuity and reduces the risk of postoperative adverse events."
01/01/2019 - "Acellular porcine corneal stroma seems to be effective in the treatment of HSK and can be used in HSK with corneal perforation by using double lamellar keratoplasty in an emergency."
04/01/2023 - "Safety and Efficacy of Double Lamellar Keratoplasty for Corneal Perforation."
06/01/2022 - "The purpose of this study was to describe a novel surgical technique using an ab interno stromal patch to treat corneal perforation and to present the histological findings of the patch after its removal during definitive mushroom keratoplasty. "
01/01/2019 - "Thirteen patients with HSK including five patients with corneal perforation were included in this study, nine patients underwent deep anterior lamellar keratoplasty (DALK) and five perforation patients underwent double lamellar keratoplasty. "

01/01/2015 - "BioCornea seems to be a safe and effective alternative for emergency treatment of corneal perforations. "
01/01/2019 - "To describe the use of equine pericardium as an off-label temporary emergency treatment of scleral and corneal perforations. "
01/01/2018 - "The clinical and histologic findings showed that autologous lamellar scleral grafts can be successfully used for the emergency treatment of corneal perforation when a corneal transplant is not available. "
06/01/2014 - "This procedure is an excellent choice for the emergency treatment of corneal perforation, especially in those centres that have no other therapeutic options, preserving the eye and visual acuity."
01/01/1996 - "They represent one of the best emergency treatments of corneal descemetoceles, preperforated corneal ulcers, impending corneal perforations and small corneal perforations. "

12/01/2022 - "To describe a case of late spontaneous postradial keratotomy corneal perforation after scleral contact lens (SCL) wear for optic correction. "
12/01/2022 - "Late Spontaneous Postradial Keratotomy Corneal Perforation After Scleral Contact Lens Use-Case Report."
01/01/2021 - "Modified Contact Lens Sandwich Technique of Glue for Management of Medium to Large Corneal Perforations in the COVID Era."
10/17/2019 - "[Corneal perforation due to 'lost' contact lenses]."
10/01/2019 - "Comparison was made in eight eyes with small traumatic corneal perforation that was sealed using therapeutic contact lenses without hydration. "