Member 1 Group C Nuclear Receptor Subfamily 2

A DNA-binding orphan nuclear receptor that has specificity for directly repeated (DR) AGGTCA sequences. It binds DNA as either as a homodimer or as a heterodimer with the closely-related orphan nuclear receptor NUCLEAR RECEPTOR SUBFAMILY 2, GROUP C, MEMBER 2. The protein was originally identified as a PROSTATE-specific protein and is involved in the regulation of variety of cellular processes, including CELL DIFFERENTIATION; CELL PROLIFERATION; and APOPTOSIS.

Also Known As:

Nuclear Receptor Subfamily 2, Group C, Member 1; Nuclear Receptor NR2C1; Nuclear Receptor TR2; Orphan Nuclear Receptor NR2C1; Orphan Nuclear Receptor TR2; TR2-11 Receptor; Receptor TR2, Nuclear; TR2 11 Receptor

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Cytoplasmic and Nuclear Receptors: 3987
    - Orphan Nuclear Receptors: 423
      - Member 1 Group C Nuclear Receptor Subfamily 2: 1
        human NR2C1 protein
        mouse Nr2c1 protein
        rat Nr2c1 protein
  - DNA-Binding Proteins: 2009
    - Orphan Nuclear Receptors: 423
      - Member 1 Group C Nuclear Receptor Subfamily 2: 1
        human NR2C1 protein
        mouse Nr2c1 protein
        rat Nr2c1 protein

Experts

1.	Chang, Chawnshang: 1 article (10/2003)
2.	Mu, Xiaomin: 1 article (10/2003)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 10/01/2003 - "Orphan nuclear receptor TR2 suppressed androgen-mediated transactivation in prostate cancer PC-3 cells, and over-expression of TR2 suppressed PSA expression. "

Related Drugs and Biologics

1.	Androgens