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Member 1 Group A Nuclear Receptor Subfamily 4

An orphan nuclear receptor that is closely related to members of the thyroid-steroid receptor gene family. It was originally identified in NERVE CELLS and may play a role in mediation of NERVE GROWTH FACTOR-induced CELL DIFFERENTIATION. However, several other functions have been attributed to this protein including the positive and negative regulation of APOPTOSIS.
Also Known As:
Nuclear Receptor Subfamily 4, Group A, Member 1; Early Response Protein NAK1; NGFI-B Orphan Nuclear Receptor; Nerve Growth Factor-inducible B Protein; Nuclear Receptor NR4A1; Nur77 Orphan Nuclear Receptor; Orphan Nuclear Receptor HMR; Orphan Nuclear Receptor NGFI-B; Orphan Nuclear Receptor NR4A1; Orphan Nuclear Receptor TR3; TR3 Orphan Nuclear Receptor; NGFI B Orphan Nuclear Receptor; Nerve Growth Factor inducible B Protein; Orphan Nuclear Receptor NGFI B
Networked: 59 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Safe, Stephen: 9 articles (04/2021 - 09/2010)
2. Lee, Syng-Ook: 5 articles (04/2021 - 09/2010)
3. Zeng, Huiyan: 5 articles (01/2020 - 10/2014)
4. Zhao, Dezheng: 5 articles (01/2020 - 10/2014)
5. Li, Yan: 4 articles (01/2020 - 10/2014)
6. Chang, Xiaolan: 4 articles (01/2019 - 12/2015)
7. Huang, Dongyang: 4 articles (01/2019 - 12/2015)
8. Liang, Bin: 4 articles (01/2019 - 12/2015)
9. Song, Xuhong: 4 articles (01/2019 - 12/2015)
10. Xie, Xina: 4 articles (01/2019 - 12/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Osteosarcoma (Osteogenic Sarcoma)
09/19/2013 - "Five selected hub proteins, B-cell translocation gene 2 (BTG2), FBJ murine osteosarcoma viral oncogene homolog (FOS), nuclear receptor subfamily 4, group A, member 1 (NR4A1), NR4A member 2 (NR4A2), and NR4A member 3 (NR4A3), were mainly related to angiogenesis and B-cell activation. "
12/01/2007 - "The gene list generated by this comparison included: activating transcription factor 3, B-cell translocation gene (BTG2), Nuclear receptor subfamily 4, group A, member 1 (NR4A1), NR4A2, NR4A3, early growth response 1, v-fos FBJ murine osteosarcoma viral oncogene homolog (c-FOS), FOSB, and Jun family member B (JUNB). "
05/01/2012 - "Refeeding with a 50 % casein diet after 48 h of fasting led to a rapid (within 2-3 h) and abnormal elevation in serum ALT (P = 0·006) and AST (P = 0·001) activities and a marked increase in liver Finkel-Biskis-Jinkins (FBJ) osteosarcoma oncogene (P = 0·007) and nuclear receptor subfamily 4, group A, member 1 (P = 0·002) mRNA levels. "
09/01/2022 - "The present study evaluated expression patterns of chemokine (C-C motif) ligand 2 gene/Monocyte chemoattractant protein-1 gene (CCL2/MCP-1), prostaglandin F2 alpha receptor gene (PTGFR) and immediate early genes including nuclear receptor subfamily 4, group A, member 1 (NR4A1), early growth response 1 (EGR1) and FBJ murine osteosarcoma viral oncogene homolog (FOS) in cells of the bovine corpus luteum after intrauterine infusion of a low dose of prostaglandin F2α (PGF2A) aimed at enhancing our understanding of the mechanisms of luteolysis. "
3. Pancreatic Neoplasms (Pancreatic Cancer)
4. Rhabdomyosarcoma
5. Inflammation (Inflammations)

Related Drugs and Biologics

1. Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
2. Dinoprost
3. Prostaglandins
4. Proteins (Proteins, Gene)
5. Messenger RNA (mRNA)
6. Orphan Nuclear Receptors
7. Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
8. Dynamin I
9. Dynamins (Dynamin)
10. GTP Phosphohydrolases (GTPases)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)