Orphan Nuclear Receptors

A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.

Also Known As:

Networked: 423 relevant articles (7 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Safe, Stephen: 16 articles (05/2022 - 03/2010)
2.	Choi, Hueng-Sik: 12 articles (01/2021 - 05/2004)
3.	Lee, Syng-Ook: 8 articles (05/2022 - 03/2010)
4.	Lee, In-Kyu: 7 articles (01/2021 - 02/2007)
5.	Kim, Don-Kyu: 5 articles (01/2021 - 01/2012)
6.	Lee, Chul-Ho: 5 articles (01/2021 - 08/2013)
7.	Wu, Dinglan: 5 articles (01/2021 - 05/2015)
8.	Park, Keun-Gyu: 5 articles (01/2019 - 02/2007)
9.	Giguère, Vincent: 5 articles (01/2018 - 07/2005)
10.	Murphy, Evelyn P: 5 articles (04/2013 - 10/2009)

Related Diseases

1.	Allergic Rhinitis 02/15/2011 - "To study the effects of allergen and corticosteroid on T help 17 (Th17) and orphan nuclear receptor gammat (RORγt) in allergic-rhinitis mice. " 08/01/2017 - "Furthermore, treatment with AST or DEX significantly suppressed the mRNA and protein expression levels of the transcription factor GATA‑3 and retinoic acid receptor‑related orphan nuclear receptor (ROR)γt in tissue samples isolated from the spleen and nasal mucosa of mice with allergic rhinitis. " 06/01/2023 - "Saikosaponin D inhibits nasal inflammation by regulating the transcription factors T-box protein expressed in T cells/GATA-3 and retinoic acid-related orphan nuclear receptor γt in a murine model of allergic rhinitis." 08/01/2017 - "Protective effects of astragaloside IV against ovalbumin-induced allergic rhinitis are mediated by T-box protein expressed in T cells/GATA-3 and forkhead box protein 3/retinoic acid-related orphan nuclear receptor γt."
2.	Insulin Resistance 05/01/2012 - "Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models." 11/01/2022 - "Orphan nuclear receptor NUR77 relieves insulin resistance in HTR-8/SVneo trophoblast cells through activation of autophagy and insulin signaling." 03/01/2013 - "Prostaglandin A2 enhances cellular insulin sensitivity via a mechanism that involves the orphan nuclear receptor NR4A3." 11/01/2009 - "Expression of the orphan nuclear receptor Nur77, which is induced by beta-adrenergic signaling and is associated with insulin sensitivity, was lower in LCR (P < 0.05). " 03/01/2012 - "The retinoic acid receptor-related orphan nuclear receptor γ1 (RORγ1): a novel player determinant of insulin sensitivity in morbid obesity."
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 03/15/2021 - "In addition to current oral treatments and biologics, a new treatment option for psoriasis is now being developed, such as retinoic-acid-receptor-related orphan nuclear receptor γt inhibitors, IL-36 receptor antagonist, or aryl hydrocarbon receptor agonist. " 04/09/2020 - "The retinoic acid receptor-related orphan nuclear receptor γt (RORγt), a promising therapeutic target, is a major transcription factor of genes related to psoriasis pathogenesis such as interleukin (IL)-17A, IL-22, and IL-23R. " 01/01/2021 - "The retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt), which is a promising therapeutic target for immune diseases, is a major transcription factor of genes related to psoriasis pathogenesis, such as interleukin (IL)-17A, IL-22, and IL-23R. " 12/20/2018 - "Finally,both the psoriasis AMSCs+PBL co-culture group and the healthy people AMSCs+PBL co-culture group showed no obvious inhibitory effect on the expression and secretion of Th17 transcription factor retinoid-related orphan nuclear receptor Γt and pro-inflammatory cytokines IL-17 and IL-23 in PBL,and there was no significant difference between these two groups.Conclusions"
4.	Hepatocellular Carcinoma (Hepatoma) 01/01/2022 - "Nur77, an orphan nuclear receptor, has antitumor activity in hepatocellular carcinoma (HCC). " 10/01/2008 - "The induction of orphan nuclear receptor Nur77 expression by n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma cell therapy." 01/01/2012 - "Recently the Small Heterodimer Partner (SHP), an orphan nuclear receptor, was suggested to be involved as a tumor suppressor in hepatocellular carcinoma development. " 01/01/2012 - "Loss of the orphan nuclear receptor SHP is more pronounced in fibrolamellar carcinoma than in typical hepatocellular carcinoma." 12/01/2022 - "Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma."
5.	Endometrial Neoplasms (Endometrial Cancer) 08/01/2023 - "Overexpression of the orphan nuclear receptor NR2F6 is associated with improved survival across molecular subgroups in endometrial cancer patients." 05/01/2006 - "[Regulatory effect of 17beta-estradiol on expression of orphan nuclear receptor ERRalpha in endometrial carcinoma cell lines]." 03/01/2002 - "The agonist activity of tamoxifen is inhibited by the short heterodimer partner orphan nuclear receptor in human endometrial cancer cells."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Tretinoin (Retinoic Acid)
3.	Ovalbumin
4.	Transcription Factors (Transcription Factor)
5.	Retinoic Acid Receptors (Retinoic Acid Receptor)
6.	Ligands
7.	Forkhead Transcription Factors (Forkhead Box Proteins)
8.	Metformin (Glucophage)
9.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
10.	Fluvoxamine (Luvox)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Castration
5.	Cell- and Tissue-Based Therapy (Cell Therapy)