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Aspartic Acid Proteases

A subclass of peptide hydrolases that depend on an ASPARTIC ACID residue for their activity.
Also Known As:
Aspartyl Proteases; Acid Protease, Aspartic; Acid Proteases, Aspartic; Acid Proteinase, Aspartic; Protease, Aspartic Acid; Protease, Aspartyl; Proteases, Aspartic Acid; Proteases, Aspartyl; Proteinase, Aspartic; Proteinase, Aspartic Acid; Proteinase, Aspartyl; Proteinases, Aspartic; Proteinases, Aspartic Acid; Proteinases, Aspartyl; Aspartic Acid Protease; Aspartic Acid Proteinase; Aspartic Acid Proteinases; Aspartic Proteinase; Aspartic Proteinases; Aspartyl Protease; Aspartyl Proteinase; Aspartyl Proteinases
Networked: 410 relevant articles (5 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Haass, Christian: 12 articles (05/2013 - 10/2002)
2. Steiner, Harald: 8 articles (05/2009 - 10/2002)
3. Wolfe, Michael S: 6 articles (01/2020 - 06/2006)
4. Lichtenthaler, Stefan F: 6 articles (01/2019 - 12/2003)
5. Liu, Yang: 6 articles (09/2018 - 08/2016)
6. Hube, Bernhard: 6 articles (10/2016 - 06/2003)
7. Feng, Lin: 5 articles (03/2018 - 08/2016)
8. Jiang, Wei-Dan: 5 articles (03/2018 - 08/2016)
9. Kuang, Sheng-Yao: 5 articles (03/2018 - 08/2016)
10. Tang, Ling: 5 articles (03/2018 - 08/2016)

Related Diseases

1. Infections
2. Systemic candidiasis
3. Parasitic Diseases (Parasitic Disease)
4. B-Cell Lymphoma (Lymphoma, B Cell)
09/18/2018 - "Furthermore, the B-cell lymphoma 2(Bcl-2)/Bcl-2-associated X (Bax) ratio was found to increase, whereas cysteine-aspartic acid protease 3 (caspase-3) and light chain 3-II (LC3-II) levels were reduced after acute cold stress. "
12/01/2022 - "In addition, asprosin administration increased the testicular expression of cell proliferation (proliferating cell nuclear antigen: PCNA), cell survival (B cell lymphoma 2: Bcl2) and decreased germ cell apoptosis (Cysteine aspartic acid protease 3: Caspase 3) leading to increased sperm counts. "
12/01/2019 - "The gene expression related to extracellular matrix formation (amphiregulin, epiregulin, and hyaluronan synthase 2 [HAS2]) and apoptosis (Bcl-2-associated X [BAX], B-cell lymphoma 2, and cysteine-aspartic acid protease 3) was investigated after maturation. "
10/07/2023 - "Expression levels of apoptosis-related genes, including Cysteine-aspartic acid protease 3 (Caspase 3), Cysteine-aspartic acid protease 8 (Caspase 8), Cytochrome c (Cyt-c), tumor suppressor gene (P53), Nuclear factor kappa-B (NF-κB), and B cell lymphoma 2 ovarian killer (Bok) were significantly higher in the 26‱ salinity group than in the other groups at 24 h, but lower than those in the 0‱ salinity group at 96 h. "
07/01/2019 - "Immunohistochemical analysis of kidney tissues revealed that Tcm induced an increase in the immune response of tumor growth factor β (TGF-β) and Janus kinase (JAK) protein expressions and cysteine-aspartic acid protease 3 (caspase 3), while B-cell lymphoma 2 (Bcl2) was downregulated. "
5. Coccidioidomycosis

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Enzymes
3. HIV Protease Inhibitors
4. Peptide Hydrolases (Proteases)
5. Reactive Oxygen Species (Oxygen Radicals)
6. Messenger RNA (mRNA)
7. NF-kappa B (NF-kB)
8. Malondialdehyde (Propanedial)
9. Glutathione (Reduced Glutathione)
10. NF-E2-Related Factor 2

Related Therapies and Procedures

1. Highly Active Antiretroviral Therapy (HAART)
2. Therapeutics
3. Aftercare (After-Treatment)