Nuclear Receptor Coactivator 1

A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and THYROID HORMONE RECEPTORS. It contains a HISTONE ACETYLTRANSFRASE activity that may play a role in the transcriptional activation of CHROMATIN regions.

Also Known As:

Networked: 29 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Xu, Jianming: 3 articles (01/2022 - 07/2015)
2.	Li, Ming: 2 articles (01/2022 - 07/2015)
3.	Mo, Pingli: 2 articles (01/2022 - 07/2015)
4.	Ren, Wenjing: 2 articles (01/2022 - 07/2015)
5.	Tong, Zhangwei: 2 articles (01/2022 - 07/2015)
6.	Yu, Chundong: 2 articles (01/2022 - 07/2015)
7.	Zhang, Hao: 2 articles (10/2018 - 07/2015)
8.	Nakshatri, Harikrishna: 2 articles (10/2005 - 11/2004)
9.	Chen, Qiang: 1 article (01/2022)
10.	Guo, Peng: 1 article (01/2022)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 11/01/2013 - "Steroid receptor coactivator-1: a versatile regulator and promising therapeutic target for breast cancer." 07/01/2005 - "AIB1, a member of the steroid receptor coactivator 1 family, has been cloned on 20q12 and is a candidate oncogene in human breast cancer. " 09/15/2015 - "Nuclear receptor coactivator 1 (NCOA1) is overexpressed in a subset of breast cancer and its increased expression positively correlates with disease recurrence and metastasis. " 08/01/2009 - "In further studies, BRCA1 overexpression inhibited the recruitment of coactivators (steroid receptor coactivator 1 and amplified in breast cancer 1) and enhanced the recruitment of a corepressor (histone deacetylase 1) to the c-Myc PRE, whereas BRCA1 knockdown increased the abundance of AIB1 and decreased the abundance of HDAC1 at the c-Myc PRE. " 07/01/2007 - "The activation of the NKG2E gene by E2 and selective ER modulators was associated with the recruitment of the p160 coactivators glucocorticoid receptor-interacting protein 1 and amplified in breast cancer 1 but not steroid receptor coactivator 1. These studies identified one of the most complex ER regulatory units thus far reported and demonstrate that a cluster of flanking transcription factors collaborate with ER to induce a functional ERE in the NKG2E promoter."
2.	Carcinoma (Carcinomatosis) 10/01/2018 - "The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma." 02/01/2017 - "Here, we show that significantly higher levels of nuclear receptor coactivator 1 and significantly lower levels of miR-223-3p were detected in bladder carcinoma tissue, compared to the adjacent non-tumor tissue. " 02/01/2017 - "Together, our study highlights miR-223-3p as a previously unrecognized microRNA that inhibits bladder carcinoma invasiveness via nuclear receptor coactivator 1, and this finding may be important for developing innovative therapeutic targets in treating bladder carcinoma." 02/01/2017 - "In vitro, depletion of miR-223-3p increased bladder carcinoma cell invasion, which was abolished by overexpression of nuclear receptor coactivator 1. Bioinformatics studies demonstrate that miR-223-3p may bind to the 3'-UTR of nuclear receptor coactivator 1 messenger RNA to inhibit its protein translation in bladder carcinoma cells. " 11/15/2003 - "To examine the steroid hormone dependent growth mechanism of human endometrial hyperplasia and carcinoma, expression levels of steroid receptor cofactors, such as coactivators (steroid receptor coactivator 1 [SRC-1] and p300/cyclic AMP-response element-binding protein (p300/CBP]) and corepressors (nuclear receptor corepressor [NCoR] and silencing mediator for retinoid and thyroid-hormone receptors [SMRT]), were investigated. "
3.	Prostatic Neoplasms (Prostate Cancer) 11/01/2018 - "Because a human pharmacokinetic study indicated that single nanomolar bufalin was safely achievable in the peripheral circulation, we evaluated its cellular activity within range with the AR-positive and P53 wild-type human LNCaP prostate cancer cells in vitro Our data show that bufalin induced caspase-mediated apoptosis at 20 nmol/L or higher concentration with concomitant suppression of AR protein and its best-known target, PSA and steroid receptor coactivator 1 and 3 (SRC-1, SRC-3). " 06/01/2001 - "Here we report that a majority of recurrent prostate cancers express high levels of the androgen receptor and two nuclear receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. Overexpression of these coactivators increases androgen receptor transactivation at physiological concentrations of adrenal androgen. "
4.	Neoplasms (Cancer) 01/01/2019 - "Steroid receptor coactivator 1 (Src-1) and Twist1 are aberrantly upregulated in a variety of tumors and play an important role in tumor progression. " 02/01/2017 - "Here, we show that significantly higher levels of nuclear receptor coactivator 1 and significantly lower levels of miR-223-3p were detected in bladder carcinoma tissue, compared to the adjacent non-tumor tissue. " 03/01/2014 - "Steroid receptor coactivator 1 (SRC-1) drives diverse gene expression programs necessary for the dynamic regulation of cancer metastasis, inflammation and gluconeogenesis, pointing to its overlapping roles as an oncoprotein and integrator of cell metabolic programs. " 01/01/2018 - "Steroid receptor coactivator 1 (SRC-1) interacts with nuclear receptors and other transcription factors (TFs) to initiate transcriptional networks and regulate downstream genes which enable the cancer cell to evade therapy and metastasise. " 11/16/2010 - "Steroid receptor coactivator 1 deficiency increases MMTV-neu mediated tumor latency and differentiation specific gene expression, decreases metastasis, and inhibits response to PPAR ligands."
5.	Neoplasm Metastasis (Metastasis) 09/15/2015 - "Nuclear receptor coactivator 1 (NCOA1) is overexpressed in a subset of breast cancer and its increased expression positively correlates with disease recurrence and metastasis. " 03/01/2014 - "Steroid receptor coactivator 1 (SRC-1) drives diverse gene expression programs necessary for the dynamic regulation of cancer metastasis, inflammation and gluconeogenesis, pointing to its overlapping roles as an oncoprotein and integrator of cell metabolic programs. " 11/16/2010 - "Steroid receptor coactivator 1 deficiency increases MMTV-neu mediated tumor latency and differentiation specific gene expression, decreases metastasis, and inhibits response to PPAR ligands."

Related Drugs and Biologics

1.	Co-Repressor Proteins
2.	Proteins (Proteins, Gene)
3.	Nuclear Receptor Coactivator 2
4.	Transcription Factors (Transcription Factor)
5.	Histone Deacetylase 1
6.	Chemokine CXCL12
7.	MicroRNAs (MicroRNA)
8.	Caspases
9.	Messenger RNA (mRNA)
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Therapeutics