Cyclin T

A cyclin subtype that is found associated with CYCLIN-DEPENDENT KINASE 9. Unlike traditional cyclins, which regulate the CELL CYCLE, type T cyclins appear to regulate transcription and are components of positive transcriptional elongation factor B.

Also Known As:

Networked: 60 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rice, Andrew P: 5 articles (01/2017 - 08/2004)
2.	Goldstein, Harris: 4 articles (01/2016 - 11/2009)
3.	Zheng, Jian Hua: 3 articles (01/2016 - 11/2009)
4.	Herrmann, Christine H: 3 articles (02/2006 - 08/2004)
5.	Liou, Li-Ying: 3 articles (02/2006 - 08/2004)
6.	Könemann, Stephanie: 2 articles (01/2021 - 01/2019)
7.	Wenzel, Kristin: 2 articles (01/2021 - 01/2019)
8.	Hussain, Afzal: 2 articles (07/2019 - 09/2017)
9.	Verma, Chandan Kumar: 2 articles (07/2019 - 09/2017)
10.	Wang, Shudong: 2 articles (01/2017 - 02/2013)

Related Diseases

1.	Infections 01/13/2009 - "Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo." 01/01/2017 - "Current strategies for a functional cure of HIV-1 infection therefore are likely to require development of latency reversal agents that up-regulate CDK9 and Cyclin T1 function in resting CD4+ T cells." 01/01/2016 - "The second model, hCD4/R5/cT1 mice, consists of transgenic mice carrying human CD4, CCR5 and cyclin T1 genes, which enables murine CD4-expressing cells to support HIV-1 entry, Tat-mediated LTR transcription and consequently develop productive infection. " 09/01/2015 - "To investigate whether HSV-2 infection directly facilitates mucosal HIV-1 acquisition, we used our transgenic hCD4/R5/cT1 mouse model which circumvents major entry and transcription blocks preventing murine HIV-1 infection by targeting transgenic expression of human CD4, CCR5, and cyclin T1 genes to CD4(+) T cells and myeloid-committed cells. " 04/28/2015 - "Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection."
2.	Fibrosarcoma 11/01/2017 - "Among these, compound 6b induced a significant reduction in the expression level of CDK9 (cyclin-dependent kinase 9)/cyclin T1 in CFPAC-1 cells concomitant with attenuation of proliferative signaling mediated by c-Raf (rapidly accelerated fibrosarcoma) and p38 MAP (mitogen-activated protein) kinases. "
3.	Hypertrophy 01/01/2021 - "In this study, we determined whether the UPS and ALP are altered in a mouse model of eccentric left ventricular (LV) hypertrophy expressing both cyclin T1 and Gαq under the control of the cardiac-specific α-myosin heavy chain promoter (double transgenic; DTG). " 06/19/2009 - "These data suggest that the reduced level of CLP-1 introduced in the background of elevated levels of cyclin T1 elevates derepression of P-TEFb activity and emphasizes the importance of the role of CLP-1 in the mechanism governing compensatory hypertrophy in cardiomyocytes." 09/01/2004 - "Previously, we showed that hypertrophy is accompanied by activation of cyclin T/Cdk9, which phosphorylates the C-terminal domain of the large subunit of RNA polymerase II, stimulating transcription elongation and pre-mRNA processing; Cdk9 activity was required for hypertrophy in culture, whereas heart-specific activation of Cdk9 by cyclin T1 provoked hypertrophy in mice. "
4.	HIV Infections (HIV Infection) 11/01/2009 - "This study provides evidence that HIV infection of cells occurs in the vagina of mice expressing human CD4, CCR5, and Cyclin T1 and that HSV-2 infection increases HIV infection. " 02/01/2006 - "Cyclin T1 can be reinduced by pathogen-associated molecular patterns (PAMPs) or HIV infection. "
5.	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 06/01/2016 - "However, there have been limited studies regarding the role of cyclin T1 and Cdk9 in gastric gastrointestinal stromal tumors (GISTs). " 06/01/2016 - "Positive cyclin T expression as a favorable prognostic factor in treating gastric gastrointestinal stromal tumors."

Related Drugs and Biologics

1.	Cyclin-Dependent Kinase 9
2.	Mitogen-Activated Protein Kinases
3.	Proteins (Proteins, Gene)
4.	Phosphotransferases (Kinase)
5.	Myosin Heavy Chains (Myosin Heavy Chain)
6.	Positive Transcriptional Elongation Factor B
7.	RNA Polymerase II (RNA Polymerase B)
8.	Cyclin T
9.	Protein Kinases (Protein Kinase)
10.	Long Noncoding RNA