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Mediator Complex

A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.
Also Known As:
Mediator Transcription Complex; Mediator-Like Complex; Mediator-Like Complexes; TR-Associated Protein (TRAP) Complex; TRAP (Thyroid Hormone Associated Protein) Complex; Thyroid Hormone-Associated Protein Complex; Mediator Like Complex; Mediator Like Complexes; Thyroid Hormone Associated Protein Complex
Networked: 65 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Vahteristo, Pia: 5 articles (10/2014 - 10/2011)
2. Aaltonen, Lauri A: 4 articles (10/2014 - 10/2011)
3. Sjöberg, Jari: 4 articles (10/2014 - 10/2011)
4. Mäkinen, Netta: 4 articles (10/2014 - 10/2011)
5. Kämpjärvi, Kati: 3 articles (10/2014 - 11/2013)
6. Bützow, Ralf: 3 articles (09/2014 - 11/2013)
7. Xu, Wei: 2 articles (10/2015 - 01/2015)
8. Boyer, Thomas G: 2 articles (10/2015 - 09/2014)
9. Surti, Urvashi: 2 articles (08/2015 - 01/2012)
10. Rajkovic, Aleksandar: 2 articles (08/2015 - 01/2012)

Related Diseases

1. Neoplasms (Cancer)
2. Leiomyoma (Uterine Fibroids)
3. Pancreatic Neoplasms (Pancreatic Cancer)
4. Shock
5. Ovarian Neoplasms (Ovarian Cancer)

Related Drugs and Biologics

1. Transcription Factor TFIIB (TFIIB)
2. TATA-Binding Protein Associated Factors (TBP-Associated Factor)
3. TATA-Box Binding Protein (TATA-Binding Protein)
4. Small Interfering RNA (siRNA)
5. Interferons
6. transcription factor TFIIF (TFIIF)
7. tributyl phosphate (TBP)
8. RNA Polymerase II (RNA Polymerase B)
9. Transcription Factors (Transcription Factor)
10. Cyclins

Related Therapies and Procedures

1. Castration