|1.||Lee, Jin-A: 8 articles (01/2015 - 09/2007)|
|2.||Gao, Fen-Biao: 7 articles (02/2014 - 09/2007)|
|3.||Stenmark, Harald: 3 articles (05/2009 - 11/2007)|
|4.||Sadoul, Rémy: 2 articles (02/2015 - 09/2010)|
|5.||Goldberg, Yves: 2 articles (02/2015 - 09/2010)|
|6.||Blot, Béatrice: 2 articles (02/2015 - 09/2010)|
|7.||Han, Jeong-Ho: 2 articles (01/2015 - 05/2012)|
|8.||Jun, Mi-Hee: 2 articles (01/2015 - 05/2012)|
|9.||Jang, Deok-Jin: 2 articles (01/2015 - 05/2012)|
|10.||Ahmad, S Tariq: 2 articles (02/2014 - 09/2007)|
01/01/2015 - "Depletion of ESCRT-I in several additional cancer cell lines with inherently poor uptake resulted in improved activity of anti-miR-21. "
06/01/2014 - "Therefore the aim of this review is to provide an overview on different model systems used to study the role of the ESCRT machinery in cancer development, to highlight common grounds and present certain controversies in the field."
01/01/2015 - "Collectively, these data support an important role for the ESCRT-I complex in the regulation of productive free uptake of anti-miRs and reveal potential avenues for improving oligonucleotide free uptake by cancer cells."
08/01/2014 - "Chmp1 is an ESCRT-III component and a putative tumor suppressor in humans. "
06/01/2014 - "While it is clear that the function of the ESCRT machinery is important for embryonic development, its role in cancer is more controversial. "
|2.||Neurodegenerative Diseases (Neurodegenerative Disease)
05/11/2012 - "Interestingly, mutations in charged multivesicular body protein 2B (CHMP2B), which is a core subunit of ESCRT-III, have been identified in some neurodegenerative diseases. "
09/01/2010 - "Taken together, these results demonstrate that a mutant ESCRT-III subunit linked to a human neurodegenerative disease can disrupt the normal pattern of spine development."
09/18/2007 - "These findings indicate that ESCRT-III dysfunction is associated with the autophagy pathway, suggesting a novel neurodegeneration mechanism that may have important implications for understanding FTD and other age-dependent neurodegenerative diseases."
01/01/2006 - "Candidate gene analysis of BCL2, however, excludes most of this gene, except its promoter region, and draws attention to the neighboring gene VPS4B, part of the endosomal protein-sorting machinery ESCRT-III which is involved in several neurodegenerative diseases."
05/15/2009 - "In this review we discuss the possible roles of ESCRTs in protection against cancer, neurodegenerative diseases and bacterial infections, and we highlight the fact that many RNA viruses exploit the ESCRT machinery for the final abscission step of their budding from cells. "
|3.||Bacterial Infections (Bacterial Infection)
07/01/2014 - "Previous studies have indicated an infection route involving multi-vesicular bodies (MVBs), and an essential element in their biogenesis is the ESCRT machinery. "
10/01/2011 - "This echoed a number of recent studies which showed that the ESCRT-III complex is essential to productive infection. "
07/01/2014 - "These results demonstrate that TSG101 plays an important part in infection with diverse PVs, and suggests that trafficking of HPV through the ESCRT machinery and MVBs is part of infectious virus entry. "
02/26/2008 - "Using a Drosophila model of infection, we identify three host cell activities, Rab7, CG8743, and the ESCRT machinery, that modulate the mycobacterial phagosome. "
03/26/2009 - "The involvement of the ESCRT machinery in suppressing diseases such as cancer, neurodegeneration and infections underscores its importance to the cell."
02/01/2014 - "A mutation in CHMP2B (CHMP2B(Intron5), an ESCRT-III component) that is associated with a hereditary form of frontotemporal dementia (FTD3) disrupts the endosomal-lysosomal pathway and causes accumulation of autophagosomes and multilamellar structures. "
09/01/2010 - "In humans, dominant mutations in the ESCRT-III subunit CHMP2B cause frontotemporal dementia (FTD). "
10/01/2009 - "In flies and cultured mammalian cells, autophagosomes accumulate when ESCRT-III is rendered dysfunctional by reduced activity of its subunits or by ectopic expression of mutant CHMP2B associated with frontotemporal dementia linked to chromosome 3 (FTD3). "
07/01/2009 - "Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia."
12/31/2008 - "Interestingly, rare mutations in CHMP2B, an ESCRT-III subunit, are associated with frontotemporal dementia linked to chromosome 3 (FTD3). "
|1.||Endosomal Sorting Complexes Required for Transport
|4.||Proteins (Proteins, Gene)
|7.||Receptor-Interacting Protein Serine-Threonine Kinases
|8.||Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
|9.||N-Ethylmaleimide-Sensitive Proteins (N-Ethylmaleimide-Sensitive Fusion Protein)