|2.||Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
|4.||Brain Neoplasms (Brain Tumor)
|1.||van der Knaap, Marjo S: 29 articles (07/2015 - 02/2002)|
|2.||Scheper, Gert C: 15 articles (04/2014 - 11/2003)|
|3.||Schiffmann, Raphael: 9 articles (05/2013 - 06/2003)|
|4.||Labauge, Pierre: 9 articles (12/2012 - 06/2003)|
|5.||Proud, Christopher G: 8 articles (12/2015 - 11/2003)|
|6.||Vanderver, Adeline: 8 articles (04/2015 - 01/2008)|
|7.||Boespflug-Tanguy, Odile: 8 articles (01/2015 - 06/2003)|
|8.||Onodera, Osamu: 8 articles (01/2014 - 01/2007)|
|9.||Gärtner, Jutta: 8 articles (12/2012 - 04/2005)|
|10.||Wu, Ye: 7 articles (07/2015 - 02/2009)|
|1.||Methotrexate (Mexate)FDA LinkGeneric
02/01/1998 - "Two patients had diffusely delayed flow studies and both developed methotrexate leukoencephalopathy. "
01/01/1989 - "An experimental study on the pathogenesis of methotrexate (MTX)-related neurotoxicity including disseminated necrotizing leukoencephalopathy (DNL) was conducted in cats. "
01/01/2015 - "A unique radiological case of intrathecal methotrexate-induced toxic leukoencephalopathy."
03/20/2014 - "Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. "
02/01/2014 - "Leukoencephalopathy due to oral methotrexate."
|2.||Leucovorin (Folinic Acid)FDA Link
01/01/1990 - "The leukoencephalopathy, documented clinically and by CT and EEG, cleared after 2350 mg of leucovorin (citrovorum factor, folinic acid) was given in addition to the 135 mg given as part of the therapy. "
03/20/2014 - "A high 42-hour plasma MTX to leucovorin ratio (measure of MTX exposure) was associated with increased risk of leukoencephalopathy in multivariable analysis (P = .038). "
01/01/1990 - "A review of the literature suggests that leukoencephalopathy may be prevented by high doses of leucovorin and can be treated by high doses, if lower doses were used initially. "
08/01/2009 - "Prevention of neurotoxicity by high-dose folinic acid rescue after high-dose methotrexate and intrathecal methotrexate without compromising cure inspite of previous transient leukoencephalopathy after intrathecal methotrexate."
01/01/1990 - "Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature."
08/01/2008 - "The purpose of this study was to determine if proton MR spectroscopic imaging ((1)H-MRSI) may help identify tissue pathophysiology in patients with leukoencephalopathies. "
04/01/2004 - "MR imaging and proton MR spectroscopic studies in Sjögren-Larsson syndrome: characterization of the leukoencephalopathy."
02/01/2009 - "Proton magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) yield different parameters for characterizing the evolution of a demyelinating white matter disease. "
06/01/2007 - "A novel leukoencephalopathy was recently identified based on magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy ((1)H-MRS) findings. "
08/01/2003 - "The authors report a patient diagnosed as multifocal inflammatory leukoencephalopathy for which thallium-201 (201Tl) single photon emission computed tomography (SPECT) and proton magnetic resonance spectroscopy (MRS) were employed as noninvasive diagnostic tools. "
09/01/1997 - "The clinical features, electrophysiologic manifestations, and imaging studies strongly indicated a lipophilic toxin-induced demyelinating process, mainly involving the central motor system, as the most likely cause of heroin leukoencephalopathy. "
07/01/2015 - "The discussion summarizes eight previously reported cases of intravenous heroin associated spongiform leukoencephalopathy and compares them to the authors'case."
07/01/2015 - "The authors report a 41-year-old man who was diagnosed with delayed spongiform leukoencephalopathy three weeks after injecting heroin intravenously. "
07/01/2015 - "Heroin-associated spongiform leukoencephalopathy is a rare, and sometimes fatal, condition usually caused by vapor inhalation of heroin. "
07/01/2015 - "Intravenous Heroin-Associated Delayed Spongiform Leukoencephalopathy: Case Report and Reviews of the Literature."
05/01/2014 - "The diagnosis of CO-mediated delayed post-hypoxic leukoencephalopathy was assumed after exclusion of other mimickers. "
05/01/2014 - "Delayed leukoencephalopathy is an uncommon complication of hypoxic-ischemic events of different etiologies, including carbon monoxide intoxication. "
05/01/2014 - "Delayed leukoencephalopathy after acute carbon monoxide intoxication."
10/10/2012 - "Higher thoracic radiation dose was associated with impaired cardiac diastolic function (E/E'; ratio of peak mitral flow velocity of early rapid filling [E] to early diastolic velocity of the mitral annulus [E']; P = .003), impaired pulmonary function (diffusing capacity of lungs for carbon monoxide [DL(co)(corr); P = .04), and leukoencephalopathy (P = .02). "
05/01/2012 - "Delayed restricted diffusion in carbon monoxide leukoencephalopathy."
06/01/1992 - "Leukoencephalopathy induced by tegafur: serial studies of somatosensory evoked potentials and cerebrospinal fluid."
10/15/2015 - "Lethal leukoencephalopathy secondary to Tegafur, a 5-fluorouracil prodrug."
11/01/1998 - "We report an autopsy case of a 64 year-old Japanese man diagnosed as having leukoencephalopathy caused by tegafur, a 5-fluorouracil derivative, and review seven previous cases, mostly reported in Japan. "
06/01/1992 - "A case of leukoencephalopathy induced by tegafur, an antineoplastic derivative of 5-FU, is reported. "
11/01/1998 - "Leukoencephalopathy induced by chemotherapy with tegafur, a 5-fluorouracil derivative."
10/01/1996 - "CT scan detected minor brain alterations in 9 patients: 6 of these, the 4 with merosin deficiency and 2 others in whom merosin was not evaluated, presented leukoencephalopathy: on neuroimaging reappraisal it was unchanged in 3, improved in 2 and worse in 1 (a merosin-deficient case). "
10/01/1996 - "Overall, during our study the brain alterations found in classical CMD showed a stationary or an improving course; progressive worsening was observed only in 1 of 4 merosin-deficient cases with leukoencephalopathy."
12/01/2007 - "Merosin-negative CMD should be considered in the imaging differential diagnosis of white matter diseases. "
10/01/1998 - "Initial investigations revealed a leukoencephalopathy and cortical dysplasia, but the patient subsequently was shown to have merosin-positive congenital muscular dystrophy. "
|8.||Factor IX (PTC)FDA LinkGeneric
01/01/1999 - "Although the association between SLE and PTC has been reported previously in 21 cases, the findings of leukoencephalopathy is known in only one other patient."
01/01/1999 - "We describe an adolescent with systemic lupus erythematosus (SLE) and pseudotumor cerebri (PTC) associated with diffuse white matter lesions (leukoencephalopathy) on neuroimaging studies. "
09/10/2013 - "The efficacy of SMG-8 knockdown to improve the mutant phenotype was confirmed using another cell line, from a cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy patient who carries a PTC-containing mutation in HtrA serine peptidase 1. Our results suggest that SMG-8 is an appropriate target for inhibiting NMD to improve NMD-exacerbated mutant phenotypes. "
|9.||Tacrolimus (Prograf)FDA LinkGeneric
03/01/2011 - "Tacrolimus leukoencephalopathy--is it posterior reversible encephalopathy syndrome?"
01/01/2010 - "Tacrolimus-related posterior reversible leukoencephalopathy (PRLE) is a rare complication which should be recognized by clinicians who regularly use immunosuppressive therapy. "
09/01/2008 - "[Reversible posterior leukoencephalopathy secondary to treatment with tacrolimus]."
09/28/2004 - "Tacrolimus leukoencephalopathy: a neuropathologic confirmation."
04/01/2004 - "Magnetic resonance imaging for the diagnosis of acute leukoencephalopathy in children treated with tacrolimus."
|10.||Cyclosporine (Ciclosporin)FDA LinkGeneric
02/01/2007 - "Under immunosuppressive treatment with cyclosporine A (CSA) the patient developed early-onset (day +33) and ultimately fatal leukoencephalopathy. "
10/01/2003 - "Posterior leukoencephalopathy with cyclosporine."
12/01/2002 - "Steroid therapy was ineffective and cyclosporin A (CsA) was discontinued due to its neurotoxicity with the development of leukoencephalopathy. "
07/01/2002 - "This is an example of posterior leukoencephalopathy owing to cyclosporine toxicity. "
11/01/2001 - "In the second case, the patient developed a leukoencephalopathy following cyclosporin administration. "
|1.||Drug Therapy (Chemotherapy)
11/01/2011 - "If leukoencephalopathy was suspected, chemotherapy should have been discontinued as soon as possible. "
10/01/2011 - "While classic radionecrosis or chemonecrosis have become less common, more subtle changes such as progressive cognitive dysfunction are increasingly reported after RT (radiation-induced leukoencephalopathy) or chemotherapy (administered alone or in combination). "
09/01/2010 - "Presented here are four cases of reversible posterior leukoencephalopathy induced by chemotherapy, with a brief review of the literature and consideration of possible mechanisms. "
09/01/2010 - "Reversible posterior leukoencephalopathy, defined by both clinical and neuroimaging findings, can affect children receiving chemotherapy. "
06/01/2010 - "Hyperperfusion on magnetic resonance imaging in acute chemotherapy-related leukoencephalopathy."
08/01/2007 - "We report the efficacy of the steroid pulse and mizoribine (MZB) combined with plasmapheresis (PP) for a case of FSGS with leukoencephalopathy induced by cyclosporine (CyA). "
01/01/2015 - "Two cocaine users with multifocal leukoencephalopathy, treated with steroids and plasmapheresis, are described. "
08/01/1997 - "Anticoagulants, corticosteroids, intravenous gamma globulin, and intravenous cyclophosphamide had all failed to halt the progression of CAPS, but repeated plasmapheresis not only halted the condition, but it led to the reversal of a leukoencephalopathy. "
|4.||Activities of Daily Living (ADL)
01/01/2009 - "[Leukoencephalopathy due to radiotherapy]."
06/01/2005 - "After 4 years, the rate of leukoencephalopathy in patients surviving more than 12 months was 58% with and 10% without whole-brain radiotherapy given at relapse (p = 0.11). "
12/01/2002 - "Delayed neurological sequelae of radiotherapy have several manifestations; leukoencephalopathy is one of the most common. "
05/22/2001 - "Leukoencephalopathy was more severe in the group that had postoperative irradiation than in the group without radiotherapy, and correlated to poor memory performances only in the postoperative radiotherapy group. "
05/01/1998 - "To assess the clinical benefit of ventriculoperitoneal shunting in patients suffering from radiotherapy-induced leukoencephalopathy. "