Cyclin H

A cyclin subtype that is found as a component of a heterotrimeric complex containing cyclin-dependent kinase 7 and CDK-activating kinase assembly factor. The complex plays a role in cellular proliferation by phosphorylating several CYCLIN DEPENDENT KINASES at specific regulatory threonine sites.

Networked: 30 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Peng, Chen: 2 articles (01/2020 - 09/2011)
2.	Huang, Guo-Hua: 1 article (01/2022)
3.	Li, Ni: 1 article (01/2022)
4.	Song, Xiao-Hui: 1 article (01/2022)
5.	Wu, Yanyang: 1 article (01/2022)
6.	Yang, Chang-Jin: 1 article (01/2022)
7.	Chen, Ji: 1 article (01/2021)
8.	Ling, Xu: 1 article (01/2021)
9.	Mao, Lili: 1 article (01/2021)
10.	Ji, Li: 1 article (01/2020)

Related Diseases

1.	Retinoblastoma (Glioblastoma, Retinal) 03/01/2003 - "FTY720 eliminated proliferating cell nuclear antigen, retinoblastoma family members, differentiation regulated transcription factor polypetide-1, and cyclin H. " 12/01/1997 - "Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity."
2.	Carcinogenesis 01/01/2006 - "This study was designed to investigate the correlation of cyclin H expression with tumorigenesis of the endometrium and clinicopathologic variables. " 01/01/2021 - "Studies have previously shown that Cyclin H (CCNH) is involved in the tumorigenesis and development of many cancers. " 11/01/2007 - "Recent observations reveal that the components of CAK: Cdk7, MAT1 and cyclin H, may play important roles in cell cycle control, transcriptional control, and DNA repairing process, all of which are important in carcinogenesis. " 02/27/2003 - "The expression of several genes physically mapped to 2q11-2q16 and potentially involved in carcinogenesis including Ccnb (cyclin B1), Ccnh (cyclin H), Rasa (Ras GAP), Rasgrf2, Pi3kr1 (p85alpha), and Il6st (gp130) was also examined by quantitative real-time PCR and immunohistochemistry (IHC) across a large bank of PhIP-induced SD rat mammary gland carcinomas. "
3.	Neoplasms (Cancer) 07/02/2010 - "Cyclin H expression is increased in GIST with very-high risk of malignancy." 01/01/2006 - "The expression of cyclin H could be involved in the transformation of the endometrium into malignancy and might be a marker for more proliferative and malignant features. " 10/08/2002 - "RESULTS: We have determined that RA inhibits cyclin H and cdk7 expression thereby decreasing levels of phosphorylated RARalpha in human cancer cell lines. " 01/01/2021 - "Studies have previously shown that Cyclin H (CCNH) is involved in the tumorigenesis and development of many cancers. " 01/10/2023 - "The CDK-activating kinase, CDK7/cyclin H/MAT1, has recently gained tremendous attention in targeted cancer drug discovery. "
4.	Stomach Neoplasms (Stomach Cancer) 01/01/2018 - "Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family, which forms the CDK activating kinase complex with Cyclin H and RING finger protein Mat1 to control cell cycle progression and transcription by phosphorylating other CDKs and RNA polymerase II. In this study, we analyzed TCGA data and found that upregulation of CDK7 frequently occurred in human gastric cancer. "
5.	Lung Neoplasms (Lung Cancer) 11/01/2007 - "Further analyses revealed that cyclin H 11817C/T, MAT1 12199A/G, MAT1 70650A/G, MAT1 79023A/G and MAT1 85693C/T significantly influenced the susceptibility of lung cancer in a dominant genetic model while cyclin H 12128A/T and MAT1 42172A/G did in a recessive model. " 11/01/2007 - "To test whether the genetic variants of CAK genes modify the risk of lung cancer, we compared the manifestation of 25 single nucleotide polymorphisms (SNPs) and the haplotypes of Cdk7, MAT1 and cyclin H between 500 patients with lung cancer and 517 healthy controls. " 01/01/2021 - "Cyclin H Regulates Lung Cancer Progression as a Carcinoma Inducer." 11/01/2007 - "Our results suggested that genetic variants in CAK genes, Cdk7, cyclin H, MAT1, might modulate the risk of lung cancer in a gene-gene interaction mode, which consist to the biochemical interaction of corresponding proteins." 11/01/2007 - "Strongest association between cyclin H alleles and lung cancer patients was found in the non-smoke subpopulation. "

Related Drugs and Biologics

1.	Proliferating Cell Nuclear Antigen (PCNA)
2.	Transcription Factors (Transcription Factor)
3.	Fingolimod Hydrochloride (FTY720)
4.	Proteins (Proteins, Gene)
5.	Cyclin-Dependent Kinases (cdk Proteins)
6.	Cyclin-Dependent Kinase-Activating Kinase
7.	RNA Polymerase II (RNA Polymerase B)
8.	Cyclins
9.	Messenger RNA (mRNA)
10.	Cyclin B1