Cyclin D

A cyclin subtype that is specific for CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. Unlike most cyclins, cyclin D expression is not cyclical, but rather it is expressed in response to proliferative signals. Cyclin D may therefore play a role in cellular responses to mitogenic signals.

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Networked: 612 relevant articles (9 outcomes, 55 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bergsagel, P Leif: 7 articles (04/2017 - 08/2003)
2.	Kuehl, W Michael: 5 articles (03/2014 - 08/2003)
3.	Bai, Qian: 3 articles (06/2022 - 07/2018)
4.	Fang, Yujiang: 3 articles (06/2022 - 07/2018)
5.	Wakefield, Mark R: 3 articles (06/2022 - 07/2018)
6.	Xiao, Huaping: 3 articles (06/2022 - 07/2018)
7.	Zhu, Ziwen: 3 articles (06/2022 - 07/2018)
8.	Wang, Shudong: 3 articles (01/2022 - 01/2018)
9.	Bartek, Jiri: 3 articles (01/2021 - 10/2002)
10.	Bartkova, Jirina: 3 articles (01/2021 - 10/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "The effect of APRIN depletion on cancer cell proliferation was examined in the present study, and the IL-6/STAT3/cyclin D axis was identified as a novel regulatory mechanism. " 01/01/2017 - "To date, this is the first preclinical study evaluating the response to CDK4/6 inhibition in endometrial malignancies driven by PTEN deficiency, and it reveals an important role of cyclin D-CDK4/6 activity in their development. " 11/01/2001 - "Aberrant levels of p53, p16, cyclin D or E were comparable to published studies indicating that the clinicopathological distribution of these cases did not favor advanced stage tumors. " 11/26/2023 - "Besides, it elevated the oxidative stress, the expression of key apoptotic genes and suppressed the expression of key oncogenes (NF-κB, BCL2 and cyclin D); implying its promising efficacy in cancer treatment as adjuvant drug. " 01/01/2023 - "CCND, the gene encoding cyclin D, is known to be amplified in a variety of solid tumors. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "This study provides a novel insight regarding the potential role of cyclin D-CDK4/6-pRb pathway in mediating the proliferative effects of BPS in breast cancer cells." 08/01/2017 - "The aims of the present study were to validate this differential ER-related effect and furthermore explore the relationship between cyclin D overexpression and CCND1 gene amplification status in a node-negative breast cancer case-control study. " 09/01/2022 - "Dysregulation of the cyclin D-CDK4/6-INK4-RB pathway, which leads to uncontrolled cell proliferation, is frequently observed in breast cancer. " 01/01/2021 - "Our findings indicated that the high expression of NUDT5 is probably involved in the poor prognosis of breast cancer via the activation of the AKT / Cyclin D pathways, which could be a prognostic factor and potential target in the diagnosis and treatment of breast cancer." 01/01/2021 - "The high expression of NUDT5 indicates poor prognosis of breast cancer by modulating AKT / Cyclin D signaling."
3.	Retinoblastoma (Glioblastoma, Retinal) 01/01/2019 - "To determine a molecular profile/phenotype that will predict CDK4/6 inhibitor activity, researchers will have to take into account simultaneously occurring events in the cyclin-D/CDK4/CDK6/retinoblastoma and associated pathways." 01/06/2015 - "We found that simultaneous mutation of lin-35, a retinoblastoma (Rb)-related gene, and fzr-1, an orthologue to the APC/C co-activator Cdh1, completely eliminates the essential requirement of CDK4/6-cyclin D (CDK-4/CYD-1) in C. " 02/01/2010 - "Under hypoxic condition, the silencing of STC2 reduced while the overexpression of STC2 increased the levels of phosphorylated retinoblastoma and cyclin D in both SKOV3 and MCF7 cells. " 12/01/1999 - "This indicates that the activities of the retinoblastoma family members, via the cyclin D pathway, are likely to be the major targets for MAD1-mediated inhibition of proliferation in primary mouse fibroblasts." 10/10/1998 - "Previously, we have shown that the retinoblastoma susceptibility gene product (pRb), a key substrate of cyclin D-cdk complex, was maintained in the hypophosphorylated state in the CeReS-18-inhibited cells. "
4.	Carcinogenesis 07/01/2008 - "We also found that lower levels of tumorigenesis were correlated with the decreased expression of cyclin D and CDK as well as decreased cell proliferation. " 12/01/1996 - "Major advances have also been made in our understanding of a key role of the pathway involving cyclin D, Cdks, CKIs, pRb and E2F both in commitment to traversing the cell cycle and in restraining oncogenesis." 10/01/1995 - "These results suggest that cyclin D overexpression is frequently involved in keratinocyte carcinogenesis and that this is an early event, as well as p53 abnormality. " 07/01/1995 - "Although the absence of p53 immunoreactivity in this mouse model differs from the observed changes in human premalignant squamous lesions, the sequence of morphological changes and the final incidence of p53 and cyclin D staining abnormalities are very similar to the well-known alterations that take place during human squamous carcinogenesis." 02/01/1993 - "Cyclin D and oncogenesis."
5.	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 02/01/2007 - "The most promising results have been seen in mantle cell lymphoma (MCL), likely because of its dependence on Cyclin D, the translation of which is largely regulated by mTOR activity. " 12/01/2020 - "Mantle cell lymphomas (MCLs) are the prototypic B-cell non-Hodgkin lymphomas defined by cyclin D1 gene (CCND1; or other cyclin D family gene) rearrangements. " 09/01/2018 - "Immunophenotypically, tumor proliferate cells expressed CD20, CD76b, CD5, and cyclin D, and the tumor immunophenotype matched mantle cell lymphoma. " 03/01/2003 - "Immunohistochemistry of a biopsied lymph node revealed that lymphoma cells were positive for cyclin D 1. Mantle cell lymphoma (MCL) was diagnosed at clinical stage IV A. " 08/01/1997 - "BCL-1 (PRAD-1/cyclin D-1) overexpression distinguishes the blastoid variant of mantle cell lymphoma from B-lineage lymphoblastic lymphoma."

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Aromatase Inhibitors
3.	Cyclin E
4.	Cyclin-Dependent Kinase 4
5.	ribociclib
6.	Cyclin-Dependent Kinases (cdk Proteins)
7.	Retinoblastoma Protein
8.	Cyclin D1
9.	Estrogen Receptors
10.	abemaciclib

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Chemoprevention
4.	Transplantation
5.	Immunotherapy