Rare autosomal recessive syndrome of extreme insulin resistance due to mutations in the binding domain of INSULIN RECEPTOR. Clinical features include severe intrauterine and postnatal growth restriction, characteristic dysmorphic FACIES; HIRSUTISM; VIRILIZATION; multiple endocrine abnormalities, and early death.
Also Known As:
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities; Leprechaunisms; Rabson Mendenhall Syndrome; Syndrome, Donohue; Syndrome, Mendenhall; Syndrome, Rabson-Mendenhall; Leprechaunism; Mendenhall Syndrome; Rabson-Mendenhall Syndrome