Cathepsin Z

A ubiquitously-expressed cysteine peptidase that exhibits carboxypeptidase activity. It is highly expressed in a variety of immune cell types and may play a role in inflammatory processes and immune responses.

Also Known As:

Networked: 38 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Reinheckel, Thomas: 4 articles (10/2017 - 02/2010)
2.	Campden, Rhiannon I: 2 articles (01/2022 - 10/2017)
3.	Greene, Catherine J: 2 articles (01/2022 - 10/2017)
4.	Warren, Amy L: 2 articles (01/2022 - 10/2017)
5.	Yates, Robin M: 2 articles (01/2022 - 10/2017)
6.	Aiba, Yoshihiro: 2 articles (01/2018 - 01/2018)
7.	Eguchi, Susumu: 2 articles (01/2018 - 01/2018)
8.	Harada, Kenichi: 2 articles (01/2018 - 01/2018)
9.	Hitomi, Yuki: 2 articles (01/2018 - 01/2018)
10.	Kawashima, Minae: 2 articles (01/2018 - 01/2018)

Related Diseases

1.	Tuberculosis (Tuberculoses) 06/01/2011 - "A previous genome-wide linkage study performed by Cooke et al identified the genes melanocortin-3-receptor (MC3R) and cathepsin Z (CTSZ) as possible candidates in tuberculosis susceptibility. " 05/01/2011 - "Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study." 07/15/2008 - "An independent, multistage genetic association study in West African populations mapped this latter region in detail, finding evidence that variation in the melanocortin 3 receptor (MC3R) and cathepsin Z (CTSZ) genes play a role in the pathogenesis of tuberculosis. "
2.	Infections 10/29/2010 - "Our previous studies have shown an association between Helicobacter pylori infection, the strong up-regulation of cathepsin X (CTSX, also called cathepsin Z/P), and the development of gastric cancer. " 03/21/2022 - "microti infection the differentially expressed proteins in mice mainly include fibrinogen α (Fgα), fibrinogen β (Fgβ), Serpina1b, Serpina1c, cathepsin Z, cytochrome c oxidases (COXs), RPS11, and RPS20. "
3.	Genetic Predisposition to Disease (Genetic Predisposition) 05/01/2011 - "Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study."
4.	Stomach Neoplasms (Stomach Cancer) 10/29/2010 - "Our previous studies have shown an association between Helicobacter pylori infection, the strong up-regulation of cathepsin X (CTSX, also called cathepsin Z/P), and the development of gastric cancer. "
5.	Osteoporosis 01/01/2019 - "The results show for the first time that cathepsin Z could be a future diagnostic biomarker for osteoporosis including female osteoporosis patients over the age of 50 years." 01/01/2019 - "Importantly, cathepsin Z mRNA was significantly associated with fragility fracture in osteoporosis patients (P = 0.0018). " 01/01/2019 - "Cathepsin Z as a novel potential biomarker for osteoporosis." 01/01/2019 - "ROC analysis showed that cathepsin Z mRNA has strong diagnostic value for osteoporosis and osteoporotic fracture. " 01/01/2019 - "Cathepsin Z mRNA in human peripheral blood mononuclear cells was significantly differentially-expressed among non-osteoporotic controls, osteopenia and osteoporosis patients (p < 0.0001) and in female osteoporosis patients over the age of 50 years (P = 0.0016). "

Related Drugs and Biologics

1.	Cathepsins
2.	Peptide Hydrolases (Proteases)
3.	Messenger RNA (mRNA)
4.	Type 3 Melanocortin Receptor
5.	Proteins (Proteins, Gene)
6.	Cysteine Proteases (Cysteine Protease)
7.	Biomarkers (Surrogate Marker)
8.	Collagen
9.	Cathepsin B
10.	Blood Coagulation Factors (Coagulation Factor)