Cathepsin K

06/11/2015 - "Inhibition of Cathepsin K: A Novel and Promising Treatment for Osteoporosis."
08/01/2009 - "Inhibition of cathepsin K (CatK) is a potential new treatment for osteoporosis. "
03/01/2012 - "The usefulness of cathepsin K inhibitors in osteoporosis is now being examined in phase 2 and phase 3 clinical trials of postmenopausal osteoporotic women."
07/27/2011 - "Inhibitors of cathepsin K are in clinical trials for treatment of osteoporosis. "
05/01/2022 - "A patent review on cathepsin K inhibitors to treat osteoporosis (2011 - 2021)."

01/01/2022 - "In an in vitro study, BS inhibited osteoclast formation and bone resorption function in a dose-dependent manner, and the elevated osteoclastic-related genes induced by RANKL, such as NFATc1, cathepsin K, RANK, and TRAP, were also attenuated following BS treatment. "
01/01/2017 - "To study the role of NCX1 during osteoclast differentiation and bone resorption, we crossed mice with exon 11 of the NCX1 gene flanked by loxP sites with cathepsin K-Cre transgenic mice. "
01/01/2016 - "Morning vs evening dosing of the cathepsin K inhibitor ONO-5334: effects on bone resorption in postmenopausal women in a randomized, phase 1 trial."
02/01/2013 - "In this study, we applied a novel gene therapeutic approach using recombinant adeno-associated virus (AAV)-mediated RNAi knockdown of Cathepsin K (Ctsk) gene expression, to target osteoclasts and periapical bone resorption in a mouse model. "
04/01/2009 - "The present study describes the intracellular mechanisms by which overexpression of cathepsin K in osteoclasts results in enhanced bone resorption. "

01/01/2006 - "Serum cathepsin K concentrations reflect osteoclastic activity in women with postmenopausal osteoporosis and patients with Paget's disease."
10/01/2016 - "Pharmacological inhibition of cathepsin K: A promising novel approach for postmenopausal osteoporosis therapy."
05/01/2007 - "These data suggest that targeting cathepsin K may prove therapeutically beneficial in the treatment of diseases with accelerated bone loss such as postmenopausal osteoporosis not only by inhibiting bone resorption but also by potentially stimulating cortical bone formation."
10/01/2001 - "These data show that inhibition of cathepsin K results in a significant reduction of bone resorption in vivo and provide further evidence that this may be a viable approach to the treatment of postmenopausal osteoporosis."
01/01/2006 - "Serum concentrations of cathepsin K appear to reflect osteoclastic activity in patients with postmenopausal osteoporosis and Paget's disease of bone and may hold promise as a marker of osteoclast activity."

01/01/2022 - "Our aim was to systematically review the relevant roles of cathepsin K (CTSK) in various possible cancers in existing studies. "
03/01/2011 - "The aim of this study is to examine stromal expression of cathepsin K in skin tumors. "
08/01/2023 - "Expression of CD200 and cathepsin K (CTSK) in cancer tissues and para-cancerous tissues was analyzed by immunohistochemistry. "
01/16/2023 - "Immunohistochemistry showed that the tumor cells were strongly positive for cathepsin-K, HMB45 and TFE3. "
05/01/2022 - "All tumors were positive for MTOR and negative for Cathepsin-K. "

05/22/2015 - "We reveal that genetic deletion of cathepsin K (Ctsk) caused a radical reduction in inflammation and bone erosion within RA joint capsules and periodontal lesions, a drastic decrease in immune-cell infiltration, and a significant reduction in osteoclasts, macrophages, dendritic and T-cells. "
04/01/2013 - "Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice."
06/01/2023 - "The study evaluates the levels of matrix metalloprotease-8 (MMP-8), and Cathepsin-K (CatK) in peri-implant crevicular fluid (PICF) among patients with immediate loaded (IL) and delayed-loaded (DL) implants at different time points to know the inflammation and osteogenic status. "
02/01/2013 - "Our study shows that AAV-RNAi silencing of Cathepsin K in periapical tissues can significantly reduce endodontic disease development, bone destruction, and inflammation in the periapical lesion. "
01/01/2022 - "However, the role of cathepsin K in cutaneous inflammation is understudied. "