Apexification

Endodontic procedure performed to induce TOOTH APEX barrier development. ROOT CANAL FILLING MATERIALS are used to repair open apex or DENTAL PULP NECROSIS in an immature tooth. CALCIUM HYDROXIDE and mineral trioxide aggregate are commonly used as the filling materials.

Also Known As:

Networked: 133 relevant articles (4 outcomes, 10 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Huang, George T-J: 3 articles (06/2008 - 12/2006)
2.	Lin, Jiacheng: 2 articles (07/2022 - 11/2017)
3.	Lu, Jiaxuan: 2 articles (07/2022 - 11/2017)
4.	Zeng, Qian: 2 articles (07/2022 - 11/2017)
5.	Zhao, Wei: 2 articles (07/2022 - 11/2017)
6.	Meschi, Nastaran: 2 articles (06/2022 - 05/2022)
7.	Keinan, David: 2 articles (01/2022 - 05/2013)
8.	Forner, Leopoldo: 2 articles (02/2020 - 03/2018)
9.	Llena, Carmen: 2 articles (02/2020 - 03/2018)
10.	Kahler, Bill: 2 articles (01/2020 - 12/2008)

Related Diseases

1.	Periapical Periodontitis (Apical Periodontitis) 12/01/2010 - "To compare the therapeutic efficacy both apexification and revascularization in the immature anterior teeth of animal model with apical periodontitis, and observe the histological situation of revascularization in the root canal. " 08/01/2021 - "The aim of the present study was to investigate in the fractal dimension (FD) time-dependent changes of periapical bone after two different apexification treatments in teeth with immature apices and apical periodontitis. " 11/01/2017 - "Regenerative Endodontics Versus Apexification in Immature Permanent Teeth with Apical Periodontitis: A Prospective Randomized Controlled Study." 12/01/2016 - "Within the limitation of this study, the outcome of revascularization, wherein healing of periapical periodontitis and maturation of roots occurs, is fairly high, making it a viable treatment option in comparison with apexification." 08/01/2023 - "At 8 months, apexification with apical plug was attempted upon radiographic evidence of apical periodontitis. "
2.	Dental Pulp Necrosis 06/01/2022 - "Microscopic revascularization for pulp necrosis of young permanent teeth can effectively promote root development, lengthen root canal and increase the thickness of canal wall, which is better than apexification." 06/01/2022 - "To compare the curative effect of microscopic revascularization and apexification in the treatment of pulp necrosis of permanent teeth. " 06/01/2022 - "[Comparative study on the effect of microscopic revascularization and apexification in the treatment of pulp necrosis of permanent teeth]." 08/01/2018 - "Apexification procedures have been widely used to treat teeth with incomplete root development and pulp necrosis. " 01/01/2017 - "The use of revascularization protocols in teeth that develop pulp necrosis and exhibit early stage of root development could be a better alternative than traditional apexification techniques."
3.	Pulpitis 10/01/2023 - "For DE teeth with irreversible pulpitis, vital pulp therapy, ie, partial or full/coronal pulpotomy, should be considered when the pulpal inflammation is limited to the coronal pulp to preserve the vitality of the radicular pulp that induces apexogenesis. " 06/26/2014 - "Recently, the advances and achievements in the field of stem cell biology and regenerative medicine have inspired novel biological approaches to apexogenesis in young patients suffering from pulpitis or periapical periodontitis. " 03/01/2005 - "MTA has been proposed as a potential medicament for various pulpal procedures like pulp capping with reversible pulpitis, apexification, repair of root perforations, etc. Hence the present study was done to evaluate the efficacy of MTA as a pulpotomy medicament. " 03/01/1999 - "This article describes the clinical procedures for application of MTA in capping of pulps with reversible pulpitis, apexification, repair of root perforations nonsurgically and surgically, as well as its use as a root-end filling material." 01/01/2017 - "This article describes successful use of calcium-enriched mixture (CEM) cement and Biodentine in apexogenesis treatment in two 8-year-old patients, one with immature permanent molar diagnosed primarily with irreversible pulpitis and the other with partially vital maxillary central incisor. "
4.	Pain (Aches) 04/01/2018 - "They reduce the overall microbial load within the root canal system, help reduce inter-appointment pain, and induce apexification during RCT of permanent teeth with immature apices. " 01/01/2015 - "In 96.7% of the cases, success was observed (no pain, integrity of restoration margins, absence of radiographic alterations and apexogenesis). " 10/01/2010 - "This article describes the apexogenesis of a mandibular right second molar in a 12-year-old girl who was referred with a history of lingering pain and pain on chewing. " 05/01/2009 - "Six patients dropped from the study (as a result of pain or failure to induce bleeding after canal disinfection) and instead received a standard apexification procedure. " 10/01/2023 - "Included were studies of patients with permanent immature or mature teeth and pulp necrosis with or without signs of apical periodontitis (P) comparing ETE (I) with calcium hydroxide apexification, apical plug and root canal treatment (C) in terms of tooth survival, pain, tenderness, swelling, need for medication (analgesics and antibiotics), radiographic evidence of reduction in apical lesion size, radiographic evidence of normal periodontal ligament space, function (fracture and restoration longevity), the need for further intervention, adverse effects (including exacerbation, restoration integrity, allergy and discolouration), oral health-related quality of life (OHRQoL), presence of sinus tract and response to sensibility testing (O). "
5.	Hypersensitivity (Allergy) 10/01/2023 - "Included were studies of patients with permanent immature or mature teeth and pulp necrosis with or without signs of apical periodontitis (P) comparing ETE (I) with calcium hydroxide apexification, apical plug and root canal treatment (C) in terms of tooth survival, pain, tenderness, swelling, need for medication (analgesics and antibiotics), radiographic evidence of reduction in apical lesion size, radiographic evidence of normal periodontal ligament space, function (fracture and restoration longevity), the need for further intervention, adverse effects (including exacerbation, restoration integrity, allergy and discolouration), oral health-related quality of life (OHRQoL), presence of sinus tract and response to sensibility testing (O). " 10/01/2023 - "The objective of the study was to elucidate the effectiveness of revitalization in treating apical periodontitis in necrotic mature and immature permanent teeth based on the following PICO question: In patients with permanent immature or mature teeth and pulp necrosis with or without signs of apical periodontitis (P) what is the effectiveness of revitalization (I) in comparison with calcium hydroxide apexification, apical plug and root canal treatment (C) in terms of tooth survival, pain, tenderness, swelling, need for medication (analgesics and antibiotics), radiographic evidence of reduction of apical lesion size, radiographic evidence of normal periodontal ligament space, radiographic evidence of increased root thickness and length (not for mature teeth), tooth function (fracture and restoration longevity), need for further intervention, adverse effects (including exacerbation, restoration integrity, allergy and discolouration), oral health-related quality of life (OHRQoL), presence of sinus tract and response to sensibility testing (O). "

Related Drugs and Biologics

1.	Pemetrexed (MTA)
2.	hydroxide ion
3.	Calcium Hydroxide
4.	Anti-Bacterial Agents (Antibiotics)
5.	Analgesics (Analgesic Drugs)
6.	mineral trioxide aggregate
7.	Gutta-Percha (Guttapercha)
8.	Composite Resins
9.	tricalcium silicate
10.	Ointments (Pastes)

Related Therapies and Procedures

1.	Regenerative Endodontics
2.	Dental Pulp Capping
3.	Pulpotomy
4.	Therapeutics
5.	Apexification