Histone Chaperones

01/31/2023 - "This study aimed to investigate the effect of histone chaperones on tumor immunity in HCC. "
11/14/2022 - "Recent studies have demonstrated that multiple histone chaperones are aberrantly expressed and have distinct roles in digestive cancers. "
12/02/2020 - "We identified SSRP1, a subunit of histone-chaperone FACT complex, to be the top drug target candidate as it is highly cancer-dependent in whole-genome CRISPR-Cas9 screening across multiple MYCamp-G3-MB lines; significantly upregulated in MYCamp-G3-MB compared to normal cerebellum and most of the rest MB subtypes; its higher expression is correlated with worse prognosis; and it has a blood-brain-barrier penetrable targeted drug that has entered early phase human clinical trials already. "
02/01/2014 - "In this study, we show the histone chaperone and epigenetic regulator CHAF1A functions in maintaining the highly dedifferentiated state of this aggressive malignancy. "
01/01/2023 - "The Anti- Silencing Function of 1B histone chaperone (ASF1B) was previously studied in numerous cancers. "

01/01/2022 - "Several studies have shown that Spn1 functions as a histone chaperone to control transcription, RNA splicing, genome stability, and histone modifications. "
11/01/2023 - "Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability."
10/01/2023 - "First, we highlight new advances concerning the contribution of the histone chaperone CAF-1 and the TSK-H3.1 DNA repair pathway in preventing genomic instability during replication. "
01/01/2023 - "The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability."
01/01/2020 - "Anti-silencing factor 1A (ASF1A) is a histone chaperone and enriched in the MII oocytes as a maternal factor, which may be associated with the maintenance of genome stability. "

01/01/2019 - "Our study highlights the importance of histone chaperones to regulate multiple phases of intracellular immunity to virus infection, findings that are likely to be highly pertinent in the cellular restriction of many clinically important viral pathogens."
01/01/2023 - "The H3.3 histone chaperone complex HIRA accumulates in PML NBs upon senescence, viral infection or IFN-I treatment in primary cells. "
01/01/2021 - "Insights into the roles of histone chaperones in nucleosome assembly and disassembly in virus infection."

01/01/2023 - "The present study aimed to explore the role of histone chaperone anti‑silencing function 1B (ASF1B) in pancreatic cancer and the underlying mechanism. "

08/01/2014 - "Diverse studies have proposed that other epigenetic processes such as post-translational histone modification, the deposition of histone variants, histone chaperones, and recently non-coding RNA, can be also involved in the development of oral cancer. "