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Chemical and Drug Induced Liver Injury

A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
Also Known As:
Acute Liver Injury, Drug-Induced; Chemically-Induced Liver Toxicity; Drug-Induced Acute Liver Injury; Drug-Induced Liver Disease; Hepatitis, Drug-Induced; Hepatitis, Toxic; Liver Injury, Drug-Induced, Acute; Toxic Hepatitis; Acute Liver Injury, Drug Induced; Chemically Induced Liver Toxicity; Chemically-Induced Liver Toxicities; Disease, Drug-Induced Liver; Diseases, Drug-Induced Liver; Drug Induced Acute Liver Injury; Drug Induced Liver Disease; Drug Induced Liver Injury; Drug-Induced Hepatitides; Drug-Induced Hepatitis; Drug-Induced Liver Diseases; Drug-Induced Liver Injuries; Hepatitides, Drug-Induced; Hepatitides, Toxic; Hepatitis, Drug Induced; Injuries, Drug-Induced Liver; Injury, Drug-Induced Liver; Liver Disease, Drug-Induced; Liver Diseases, Drug-Induced; Liver Injuries, Drug-Induced; Liver Injury, Drug Induced; Liver Toxicities, Chemically-Induced; Liver Toxicity, Chemically-Induced; Toxic Hepatitides; Toxicities, Chemically-Induced Liver; Toxicity, Chemically-Induced Liver; Drug-Induced Liver Injury; Liver Injury, Drug-Induced
Networked: 2749 relevant articles (63 outcomes, 212 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Tuberculosis (Tuberculoses)
2. Hepatitis
3. Jaundice (Icterus)
4. Pruritus (Itching)
5. Liver Diseases (Liver Disease)

Experts

1. Watkins, Paul B: 52 articles (01/2022 - 01/2005)
2. Fontana, Robert J: 47 articles (04/2022 - 11/2007)
3. Yokoi, Tsuyoshi: 35 articles (10/2021 - 09/2009)
4. Chalasani, Naga: 34 articles (04/2022 - 01/2009)
5. Andrade, Raúl J: 33 articles (02/2022 - 12/2003)
6. Lucena, M Isabel: 33 articles (01/2022 - 08/2006)
7. Aithal, Guruprasad P: 25 articles (01/2022 - 11/2004)
8. Tong, Weida: 23 articles (01/2020 - 01/2009)
9. Park, B Kevin: 22 articles (11/2020 - 10/2008)
10. Bonkovsky, Herbert L: 21 articles (04/2022 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chemical and Drug Induced Liver Injury:
1. Acetaminophen (Paracetamol)FDA LinkGeneric
2. Acetylcysteine (Siran)FDA LinkGeneric
3. Isoniazid (Ftivazide)FDA LinkGeneric
4. Rifampin (Rifampicin)FDA LinkGeneric
5. Biomarkers (Surrogate Marker)IBA
6. EnzymesIBA
7. SilymarinIBA
8. Polysaccharides (Glycans)IBA
9. Glutathione (Reduced Glutathione)IBA
10. Dexamethasone (Maxidex)FDA LinkGeneric
01/01/2018 - "This study aims to determine whether dexamethasone is a safe and effective addition to the first 6-8 weeks of anti-tuberculosis treatment of TBM in patients with HIV, and investigate alternative management strategies in a subset of patients who develop drug induced liver injury (DILI) that will enable the safe continuation of rifampicin and isoniazid therapy.  Methods: We will perform a parallel group, randomised (1:1), double blind, placebo-controlled multi-centre Phase III trial, comparing the effect of dexamethasone versus placebo on overall survival in HIV-infected patients with TBM, in addition to standard anti-tuberculosis and antiretroviral treatment. "
01/01/2018 - "This study aims to determine whether dexamethasone is a safe and effective addition to the first 6-8 weeks of anti-tuberculosis treatment of TBM in patients with HIV, and investigate alternative management strategies in a subset of patients who develop drug induced liver injury (DILI) that will enable the safe continuation of rifampicin and isoniazid therapy.  Methods: We will perform a parallel group, randomised (1:1), double blind, placebo-controlled multi-centre Phase III trial, comparing the effect of dexamethasone versus placebo on overall survival in HIV-infected patients with TBM, in addition to standard anti-tuberculosis and antiretroviral treatment. "
01/01/2018 - "The secondary aim is to investigate alternative management strategies in individuals who develop drug induced liver injury (DILI) that will enable the safe continuation of rifampicin and isoniazid therapy.  Methods: We will perform a parallel group, randomised (1:1), double blind, placebo-controlled,  multi-centre Phase III non-inferiority trial, comparing dexamethasone versus placebo for 6-8 weeks in addition to standard anti-tuberculosis treatment in HIV-uninfected patients with TBM stratified by LTA4H genotype. "

Therapies and Procedures

1. Therapeutics
2. Oral Administration
3. Liver Transplantation
4. Drug Therapy (Chemotherapy)
5. Transplantation