Retinoblastoma-Binding Protein 2

A retinoblastoma binding protein that is also a member of the Jumonji-domain histone demethylases. It has demethylation activity towards specific LYSINE residues found on HISTONE H3.

Also Known As:

Networked: 18 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kaelin, William G: 2 articles (08/2011 - 03/2007)
2.	Yan, Qin: 2 articles (08/2011 - 03/2007)
3.	Choi, Hee-Joo: 1 article (01/2018)
4.	Joo, Hyeong-Seok: 1 article (01/2018)
5.	Kim, Hyung-Yong: 1 article (01/2018)
6.	Kong, Gu: 1 article (01/2018)
7.	Lee, Jeong-Yeon: 1 article (01/2018)
8.	Min, Kyueng-Whan: 1 article (01/2018)
9.	Oh, Young-Ha: 1 article (01/2018)
10.	Son, Taekwon: 1 article (01/2018)

Related Diseases

1.	Neoplasms (Cancer) 06/05/2017 - "BACKGROUND Recently, some studies have found that retinoblastoma-binding protein 2 (RBP2) is involved in the development and progression of many kinds of malignant tumors. " 12/20/2016 - "Jumonji domain-containing protein 1A (JMJD1A) plays a key role in the development and progression of several cancers. " 12/01/2015 - "To investigate the effect of retinoblastoma-binding protein 2 (RBP2) on epithelial-mesenchymal transition (EMT) in esophageal squamous cancer cells and to compare the effect of RBP2 in lung squamous cancer cells and esophageal squamous cancer cells. " 12/01/2015 - "Retinoblastoma-binding protein 2 induces epithelial-mesenchymal transition in esophageal squamous cancer cells." 06/11/2015 - "Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells."
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2014 - "Retinoblastoma binding protein 2 (RBP2) promotes HIF-1α-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway." 01/01/2014 - "The aim of this study is to detect the potential role of Retinoblastoma binding protein 2 (RBP2) in the tumor angiogenesis of non-small cell lung cancer (NSCLC). "
3.	Stomach Neoplasms (Stomach Cancer) 12/01/2013 - "MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2." 01/01/2013 - "The H3K4 demethylase retinoblastoma binding protein 2 (RBP2) is involved in the pathogenesis of gastric cancer, but its role and regulation in hepatocellular carcinoma (HCC) is unknown. " 12/01/2013 - "Retinoblastoma binding protein 2 (RBP2), a newly found histone demethylase, is overexpressed in gastric cancer. "
4.	Hepatocellular Carcinoma (Hepatoma) 06/05/2017 - "High Expression of Retinoblastoma-Binding Protein 2 (RBP2) in Patients with Hepatocellular Carcinoma and Its Prognostic Significance." 01/01/2013 - "The H3K4 demethylase retinoblastoma binding protein 2 (RBP2) is involved in the pathogenesis of gastric cancer, but its role and regulation in hepatocellular carcinoma (HCC) is unknown. " 01/01/2013 - "Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212."
5.	Carcinogenesis 08/16/2011 - "Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1."

Related Drugs and Biologics

1.	Histone Demethylases
2.	Proteins (Proteins, Gene)
3.	Lysine (L-Lysine)
4.	Histones (Histone)
5.	Chromatin
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)
7.	Small Interfering RNA (siRNA)
8.	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)
9.	Messenger RNA (mRNA)
10.	Pyruvate Kinase

Related Therapies and Procedures

1.	Therapeutics