Histone Deacetylase 2

A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 1; RETINOBLASTOMA-BINDING PROTEIN 4; and RETINOBLASTOMA-BINDING PROTEIN 7 as core components of histone deacetylase complexes.

Also Known As:

Networked: 184 relevant articles (4 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eun, Jung Woo: 6 articles (03/2014 - 04/2005)
2.	Lee, Jung Young: 6 articles (03/2014 - 04/2005)
3.	Nam, Suk Woo: 6 articles (03/2014 - 04/2005)
4.	Noh, Ji Heon: 6 articles (03/2014 - 04/2005)
5.	Bae, Hyun Jin: 5 articles (03/2014 - 01/2011)
6.	Park, Won Sang: 5 articles (03/2014 - 04/2005)
7.	Eom, Gwang Hyeon: 4 articles (11/2019 - 11/2008)
8.	Kook, Hyun: 4 articles (11/2019 - 11/2008)
9.	Rahman, Irfan: 4 articles (01/2018 - 04/2009)
10.	Barnes, Peter J: 4 articles (01/2016 - 04/2004)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2020 - "To the best of our knowledge, the current study demonstrated for the first time that miR-489-3p suppressed BC cell-derived tumor growth in vivo via the downregulation of histone deacetylase 2 (HDAC2). " 01/01/2019 - "In the present study, we found that histone deacetylase 2 (HDAC2) acts as a co-activator of tumor suppressor p53 and participates in the early molecular events following DNA damage. " 09/27/2023 - "Histone deacetylase 2 (HDAC2), belonging to the class I HDAC family, holds significant therapeutic potential as a crucial target for diverse cancer types. " 09/16/2023 - "Several histone deacetylase 2 inhibitors have shown advantages in ICIs in many solid cancers, except for HCC. " 08/01/2023 - "Histone deacetylase 2 (HDAC2), prevent the aberrant transcription of a number of genes that are primarily responsible for controlling the cell cycle, cell proliferation, and signaling pathways in numerous cancers. "
2.	Pneumonia (Pneumonitis) 12/17/2010 - "Abnormal lung inflammation and oxidant burden are associated with a significant reduction in histone deacetylase 2 (HDAC2) abundance and steroid resistance. " 01/01/2016 - "Lung inflammation and the released pro-inflammatory cytokines affect glucocorticoid receptor (GR), histone deacetylase 2 (HDAC2) and surfactant protein D (SP-D) activities in many cell types. " 04/01/2009 - "Cigarette smoke (CS)-induced lung inflammation involves the reduction of histone deacetylase 2 (HDAC2) abundance, which is associated with steroid resistance in patients with chronic obstructive pulmonary disease and in individuals with severe asthma who smoke cigarettes. "
3.	Liver Neoplasms (Liver Cancer) 08/28/2021 - "The rational design of selective histone deacetylase 2 (HDAC2) inhibitors is beneficial for the therapeutic treatment of liver cancer, though HDAC2 is highly homologous to HDAC8, which may lead to undesired side effects due to the pan-inhibition towards HDAC2 and HDAC8. " 07/28/2013 - "MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer."
4.	Penile Induration (Peyronie's Disease) 12/01/2014 - "Silencing histone deacetylase 2 using small hairpin RNA induces regression of fibrotic plaque in a rat model of Peyronie's disease." 12/01/2014 - "To examine the therapeutic effect of adenovirus encoding histone deacetylase 2 (HDAC2) small hairpin RNA (Ad-HDAC2 shRNA) in a rat model of Peyronie's disease (PD) and to determine the mechanisms by which HDAC2 knockdown ameliorates fibrotic responses in primary fibroblasts derived from human PD plaque. "
5.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2021 - "Previous studies have shown that histone deacetylase 2 (HDAC2) plays an important role in the progression of COPD. " 10/01/2020 - "Histone deacetylase 2 (HDAC2), a critical regulator of chromatin remodeling, plays a pivotal role in the development of COPD. " 01/01/2016 - "Reduced activity of histone deacetylase 2 (HDAC2) has been described in patients with chronic obstructive pulmonary disease (COPD), but the mechanisms resulting in decreased expression of this important epigenetic modifier remain unknown. " 01/01/2016 - "MicroRNA-223 controls the expression of histone deacetylase 2: a novel axis in COPD." 01/01/2016 - "Decreased Histone Deacetylase 2 (HDAC2) in Peripheral Blood Monocytes (PBMCs) of COPD Patients."

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Steroids
3.	Small Interfering RNA (siRNA)
4.	Oxidants (Oxidizing Agents)
5.	Immune Checkpoint Inhibitors
6.	Adrenal Cortex Hormones (Corticosteroids)
7.	Smoke
8.	Enzymes
9.	Dexamethasone (Maxidex)
10.	histone deacetylase 3

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Off-Label Use
4.	Electroacupuncture
5.	Chinese Traditional Medicine (Traditional Chinese Medicine)