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Cytoplasmic Dyneins

Dyneins that are responsible for intracellular transport, MITOSIS, cell polarization, and movement within the cell.
Also Known As:
Dynein, Cytoplasmic; Dyneins, Cytoplasmic; Cytoplasmic Dynein
Networked: 100 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hafezparast, Majid: 7 articles (02/2015 - 09/2003)
2. Fisher, Elizabeth M C: 5 articles (07/2014 - 09/2003)
3. Hirotsune, Shinji: 5 articles (04/2010 - 11/2005)
4. Vallee, Richard B: 4 articles (01/2016 - 05/2007)
5. Vallee, R B: 4 articles (05/2012 - 03/2000)
6. Wynshaw-Boris, Anthony: 4 articles (04/2010 - 11/2005)
7. Suzuki, Satoshi O: 3 articles (12/2018 - 05/2007)
8. Ahmad-Annuar, Azlina: 3 articles (10/2014 - 09/2003)
9. Yamada, Masami: 3 articles (04/2010 - 10/2009)
10. Mori, Daisuke: 3 articles (02/2010 - 11/2005)

Related Diseases

1. Motor Neuron Disease (Primary Lateral Sclerosis)
2. Stroke (Strokes)
3. Lissencephaly
4. Spinal Muscular Atrophy (Progressive Muscular Atrophy)
02/02/2023 - "Objective: To investigate the clinical features and gene variation characteristics of children with dynein cytoplasmic 1 heavy chain 1 (DYNC1H1) gene associated spinal muscular atrophy with lower extremity predominant (SMALED) 1. Methods: The clinical data of 4 SMALED1 children admitted to Peking University First Hospital from December 2018 to May 2021, who were found to have pathogenic variation of DYNC1H1 gene through genetic testing, except for other genes known to be related to motor retardation, were retrospectively summarized to analyze the phenotype and genotype characteristics. "
04/01/2022 - "Mutations in the cytoplasmic dynein 1 heavy chain gene (DYNC1H1) have been associated with spinal muscular atrophy with predominant lower extremity involvement (SMA-LED), Charcot-Marie-Tooth 2O (CMT2O) disease, cortical migration anomalies, and autosomal dominant mental retardation13. "
02/17/2015 - "To expand the clinical phenotype of autosomal dominant congenital spinal muscular atrophy with lower extremity predominance (SMA-LED) due to mutations in the dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1) gene. "
11/01/2020 - "Mutations in the cytoplasmic dynein 1 heavy chain gene (DYNC1H1) have been identified in rare neuromuscular (NMD) and neurodevelopmental (NDD) disorders such as spinal muscular atrophy with lower extremity dominance (SMALED) and autosomal dominant mental retardation syndrome 13 (MRD13). "
05/29/2012 - "We demonstrate that mutations in the tail domain of the heavy chain of cytoplasmic dynein (DYNC1H1) cause spinal muscular atrophy and provide experimental evidence that a human DYNC1H1 mutation disrupts dynein complex assembly and function. "
5. Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Dyneins (Dynein)
3. Dynactin Complex
4. Kinesins
5. Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
6. Axonemal Dyneins
7. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8. Tumor Suppressor Proteins (Proteins, Tumor Suppressor)
9. Tubulin
10. Platelet Activating Factor

Related Therapies and Procedures

1. Transjugular Intrahepatic Portasystemic Shunt
2. Therapeutics
3. Surgical Instruments (Clip)