Abdominal Obesity

A condition of having excess fat in the abdomen. Abdominal obesity is typically defined as waist circumferences of 40 inches or more in men and 35 inches or more in women. Abdominal obesity raises the risk of developing disorders, such as DIABETES; HYPERTENSION; and METABOLIC SYNDROME.

Also Known As:

Obesity, Abdominal; Obesity, Visceral; Visceral Obesity; Abdominal Obesities; Central Obesities; Obesities, Abdominal; Obesities, Central; Obesities, Visceral; Obesity, Central; Visceral Obesities; Central Obesity

Networked: 6390 relevant articles (133 outcomes, 691 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Insulin Resistance
2.	Obesity
3.	Hypertension (High Blood Pressure)
4.	Body Weight (Weight, Body)
5.	Type 2 Diabetes Mellitus (MODY)

Experts

1.	Després, Jean-Pierre: 36 articles (01/2020 - 07/2002)
2.	Azizi, Fereidoun: 33 articles (05/2021 - 07/2003)
3.	Kelishadi, Roya: 25 articles (01/2022 - 03/2007)
4.	Tchernof, André: 21 articles (09/2022 - 12/2003)
5.	Qorbani, Mostafa: 21 articles (02/2022 - 09/2013)
6.	Lamarche, Benoît: 21 articles (10/2019 - 01/2003)
7.	Watts, Gerald F: 20 articles (04/2016 - 02/2002)
8.	Onat, Altan: 19 articles (03/2017 - 11/2002)
9.	Bergeron, Jean: 17 articles (01/2020 - 02/2002)
10.	Chan, Dick C: 17 articles (10/2015 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Abdominal Obesity:

1.	Glucose (Dextrose)FDA LinkGeneric 01/01/2016 - "Risk prediction was significantly improved by adding these metabolites in addition to known T2D risk factors, including central obesity and glucose. " 06/05/2011 - "Aims/Introduction: The aim of the present study was to determine the predictors of deterioration of glucose tolerance in individuals with normal glucose tolerance (NGT) and abdominal obesity, and whether a lifestyle intervention to reduce visceral fat is effective in these individuals. " 01/24/2023 - "The main aim of this study was to determine the association between serum omentin-1 levels and the occurrence of central obesity and abnormal glucose tolerance, taking into account gender. " 06/01/2022 - "Our study demonstrated that abrogating gut epithelial GLUT1 activity affected the gut microbiota, fat mass accumulation, and glucose tolerance; and LCZ administration reduced fat mass accumulation and central obesity." 09/01/2018 - "Recent studies have demonstrated that a significant proportion of adolescents exhibit abdominal obesity in early-middle adolescence, and impaired glucose metabolism. "
2.	Triglycerides (Triacylglycerol)IBA 06/01/2012 - "The IG improved abdominal obesity (p = 0.016), blood pressure (p = 0.030), and triglyceride (p = 0.005) more than the CG did. " 01/01/2022 - "PM10 exposure interacts with abdominal obesity to increase blood triglycerides: a cross-sectional linkage study." 01/01/2020 - "Meta-analyses considering all-cause (103,859 individuals, 48,830 men, 55,029 women; 10 studies) and CV mortality (94,965 individuals, 44,699 men, 50,266 women; 8 studies) did not reveal any significant association for abdominal obesity and high triglycerides in either gender. " 10/01/2015 - "Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity: Multicenter Tracer Kinetic Study." 04/01/2015 - "However, this study confirmed that increasing age, abdominal obesity, systolic blood pressure and triglyceride level have positive relationship with the prevalence of diabetes and IFG. "
3.	HDL CholesterolIBA 10/11/2021 - "Subjects with TPOAb positive had a significantly greater risk of abdominal obesity (OR 1.675, 95% CI: 1.302-2.154, P < 0.001), low high-density lipoprotein cholesterol (OR: 1.603, 95% CI: 1.244-2.066, P < 0.001) and elevated blood pressure (OR: 1.418, 95% CI: 1.099-1.829, P = 0.007) as compared to those with TPOAb negative. " 05/01/1995 - "Patients with central obesity and other associated disturbances showed maximal reduction in BP and other cardiovascular risk factors with a significantly greater increase in HDL-cholesterol. " 07/01/2001 - "Results of the present study suggest that regular endurance exercise training may be particularly helpful in men with low HDL cholesterol, elevated TGs, and abdominal obesity." 07/18/2011 - "These SNPs may help to explain why low HDL-cholesterol levels and abdominal obesity frequently co-occur." 02/01/2012 - "The most common MetS parameters findings of our study were abdominal obesity (45.6%, waist circumference>88 cm) and low high-density lipoprotein cholesterol. "
4.	Insulin (Novolin)FDA Link 01/01/2019 - "Our data suggest that higher quality diet is associated with improved adiposity measures and a less insulin resistant, pro-inflammatory, pro-thrombotic and pro-atherogenic cardiometabolic profile which may impact on central obesity and MetS risk. " 01/01/2023 - "The purpose of this study was to test the hypothesis that maternal age at childbirth (MAC) was associated with central obesity in offspring among the adult population, and fasting insulin may play a role in this association as a mediating factor. " 04/01/2017 - "This study was designed to investigate whether an elevated fasting insulin level predicts abdominal obesity. " 03/01/2014 - "The purpose of this study was to determine the independent associations between physical activity (PA), cardiorespiratory fitness (CRF), abdominal obesity and insulin action in obese women. " 12/02/2009 - "This study uses a large existent cohort of patients and will generate valuable information as to the continuing effects of exercise specifically targeting cardiovascular function and disease risk, insulin metabolism, abdominal obesity, physical function, quality of life and psychological distress. "
5.	LipidsIBA 08/01/2010 - "Long-term Danhak practice, a traditional Korean exercise, was effective at reducing body fat (%) and abdominal obesity, and improved lipid profiles, self-confidence, and stress." 03/01/2013 - "In conclusion, consumption of oat reduced obesity, abdominal fat, and improved lipid profiles and liver functions. " 01/01/2023 - "The aim of this study was to simultaneously explore the associations of major dietary patterns (DP) with lipid profiles and the associations of these profiles with general and central obesity risks and to evaluate the extent to which the metabolites mediate such associations. " 01/01/2023 - "Our study identified 4 lipid metabolites associated with abdominal obesity, including PC3 (O-21:2), SM (d21:1), PG (43:6), and one did not match with any candidate compounds in the databases. " 10/17/2022 - "This study examined the prevalence of visceral obesity in Chinese adults across different body mass index (BMI) groups and their associated lipid profiles and demographic risk factors. "
6.	AdiponectinIBA 01/01/2013 - "In conclusion, circulating adiponectin levels were independently associated with dysglycemia in non-fasting Japanese employees with metabolic risk factors, but they improved the screening capacity only in those without abdominal obesity. " 01/01/2018 - "The objective of this study was to elucidate the changes in serum adiponectin levels after SC and the effects of abdominal obesity on those changes. " 03/26/2014 - "The present study results suggest that prevention of abdominal obesity could contribute to the prevention of lower adiponectin levels, especially in boys." 03/26/2014 - "The aim of the present study was to investigate the relationship between abdominal obesity and serum adiponectin complexes among population-based elementary school children in Japan. " 03/26/2014 - "There are a limited number of studies regarding the association between abdominal obesity and serum adiponectin complexes (high, medium, and low molecular weight adiponectins) among population-based elementary school children, especially in Japan, where blood collection is not usually performed during annual health examinations of school children. "
7.	LeptinIBA 10/19/2020 - "As the leptin level serves as mediator between central obesity and severity of CAN, a longitudinal study is needed to confirm that control of WC can decrease leptin levels and can be effective in reducing CAN progression." 07/01/2021 - "For this study we compared serum leptin levels between two groups of pregnant women: those with abdominal obesity (AC>88cm) and those without abdominal obesity (AC<88cm), diagnosed at the beginning of pregnancy. " 06/01/2010 - "The aim of the study was to investigate the factors contributing to serum CRP, assess the relationship between CRP level and the parameters of visceral obesity, and examine the association between leptin and CRP level in type 2 diabetic patients. " 01/01/2022 - "A novel missense mutation Lys36Arg in exon 2 of LEP was observed in one subject with abdominal obesity and decreased serum leptin level. " 10/26/2021 - "Leptin had a significant linear correlation as a parameter of central obesity with BMI and WC in all three groups, but not with WHR."
8.	C-Reactive ProteinIBA 01/01/2023 - "This study aims to determine feasibility and efficacy of an anti-inflammatory dietary intervention to lower levels of C-reactive protein in weight stable postmenopausal women with abdominal obesity. " 12/01/2010 - "The aim of this study was thus to examine the association between overall and central obesity and C-reactive protein (CRP) levels in Cypriot children of Greek ancestry. " 06/20/2023 - "General and abdominal obesity were assessed, and serum C-reactive protein (CRP) levels were measured at baseline. " 01/01/2023 - "Central obesity plays a significant mediating role in the association between HEI-2015 and high-sensitivity C-reactive protein (hs-CRP), mediating 26.87% of the associations between the two; it also mediates 15.24% of the associations between DII and hs-CRP. " 12/30/2022 - "Excessive sugar-sweetened beverages (SSB) consumption and abdominal obesity have been independently linked to numerous disorders, including diabetes and elevated C-reactive protein (CRP). "
9.	Blood Glucose (Blood Sugar)IBA 01/01/2020 - "This study estimated the prevalence and associated factors of abdominal obesity, elevated blood pressure, elevated blood glucose, and the 3-factor MetS components among urban adults in Dire Dawa, East Ethiopia. " 01/01/2016 - "In this study, the blood pressure and blood glucose levels of the patients along with their waist circumference that indicated a central obesity were specified as the determinants of microalbuminuria. " 11/08/2023 - "Other risk factors include abdominal obesity and elevated fasting blood glucose. " 06/12/2023 - "There were linear positive associations of increasing curry consumption with waist circumference, fasting blood glucose, TyG, AIP, CRI-1, CRI-2, central obesity and diabetes prevalence, and inverse association with eGFR. " 01/01/2023 - "The prevalence of abdominal obesity and high fasting blood glucose levels also significantly increased from 2019 to 2021. "
10.	CholesterolIBA 05/01/2015 - "The main aim of this study is to evaluate the association between serum cholesterol level and abdominal obesity in adult men and women in the north of Iran. " 11/01/2009 - "There are few studies that compare measures of diagnostic accuracy for selected waist cutoff points and the criteria of abdominal obesity given by the International Diabetes Federation (IDF) and the National Cholesterol Education Program (NCEP). " 11/01/2006 - "National Cholesterol Education Program's Adult Treatment Panel III, a modified Adult Treatment Panel III that adopts the World Health Organization's criterion for central obesity in Asian populations, and one recently proposed by the International Diabetes Federation, were used in the study. " 10/28/2022 - "In a subgroup analysis of individuals with normal BMI (n = 126), those with RKOA had higher VFA, more central obesity, higher levels of CRP and total cholesterol, compared with individuals without RKOA. " 10/01/2022 - "Abdominal obesity, high total cholesterol, smoking and having diabetes were associated with higher odds of having PHA excess, whereas higher education and employment were inversely associated with excess PHA. "

Therapies and Procedures

1.	Therapeutics 01/01/2015 - "[Conclusion] The use of the high-frequency current therapy may be beneficial for reducing the levels of abdominal obesity in young women. " 01/01/2015 - "Ongoing GC replacement therapy together with polymorphisms in two genes related with GC sensitivity is associated with abdominal obesity and adverse skeletal health in patients with CS in long-term remission." 01/01/2015 - "[Purpose] The aim of this study was to determine the effects of high-frequency current therapy on the abdominal obesity levels of young women. " 10/01/2021 - "Thus, flaxseed consumption could be an adjunctive therapy to attenuate central obesity. " 01/01/2021 - "Our findings illustrate the molecular mechanisms behind the intronic SNP rs12454712 for central obesity, which would be a potential and promising target for developing appropriate therapies."
2.	Glycemic Control 01/01/2022 - "The prevalence of good glycemic control in people with T2D in Anhui Province was relatively low, and gender, region, education level, central obesity and course of the disease were influencing factors. " 01/01/2022 - "The factors associated with pool glycemic control were female gender [OR = 0.67, 95%CI (0.52, 0.86), P = 0.001], higher level of education [OR = 0.47, 95%CI (0.27, 0.83), P = 0.001], living in rural areas [OR = 1.77, 95%CI (1.39, 2.26), P < 0.001], central obesity [OR = 1.58, 95%CI (1.19, 2.09), P = 0.001] and longer duration of disease [OR = 2.66, 95%CI (1.91, 3.69), P < 0.001]. " 01/01/2022 - "Hence, this paper is to evaluate the predictive performance of central obesity indices for glycemic control among adult patients with diabetes in eastern Ethiopia. " 01/01/2021 - "Conclusions: T1D patients with alexithymia had higher prevalence of high Gal3BP levels, depression, impaired glycemic control, anxiety, and abdominal obesity, which are known risk factors for cardiovascular disease. " 01/01/2021 - "Most patients had poor glycemic control (71⋅1 %), BMI ≥ 25 kg/m2 (85⋅2 %) and central obesity (75⋅8 %), and moderate (54⋅4 %) and poor (32⋅9 %) level of NQOL. "
3.	Caloric Restriction 12/01/2016 - "With no concomitant caloric restriction, an HIIT program in postmenopausal women with T2D (twice a week for 16 weeks) appeared to be more effective for reducing central obesity than MICT, and could be proposed as an alternative exercise training program for this population." 07/01/2011 - "Increasing low fat milk consumption significantly reduces the general and central obesity beyond a low calorie diet." 05/01/1997 - "Dieting and exercise have different consequences in the two genders: men, unlike women, maintain HDL levels and lose central obesity simply by dieting, while women require exercise in addition to restricted caloric intake to produce the same effects. " 11/15/2012 - "Thus, postnatal caloric restriction superimposed on intrauterine under nutrition significantly improved insulin sensitivity and adiposity of rats that would otherwise develop metabolic inflexibility and visceral obesity. " 12/01/2020 - "Our results indicate that dAGEs restriction plus a low-calorie diet is superior to a low-calorie diet in amelioration of central obesity and IR at least partially through reduction of OS and inflammation in Mets subjects."
4.	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/01/2020 - "In this cohort study, 78 Chinese patients with central obesity (WC ≥ 90 cm for males, WC ≥ 85 cm for females) or BMI above 27.5 kg/m2 underwent gastric bypass between October 2010 and October 2012. " 09/01/2015 - "However, since 2011, laparoscopic Roux-Y gastric bypass (LRYGB) with a small stomach pouch has been performed at our center, with prominent resolution of abdominal visceral obesity and lower incidences of postoperative complications. " 08/01/2014 - "Although insulin resistance and central obesity play an important role in the pathogenesis, the factors that determine its development and ultimate remission after Roux-en-Y gastric bypass (RYGB) are not fully understood. " 11/01/2018 - "Erratum: The role of visceral adipose tissue on improvement in insulin sensitivity following Roux-en-Y gastric bypass: a study in Chinese diabetic patients with mild and central obesity." 11/01/2018 - "The role of visceral adipose tissue on improvement in insulin sensitivity following Roux-en-Y gastric bypass: a study in Chinese diabetic patients with mild and central obesity."
5.	Bariatric Surgery 09/01/2011 - "Visceral obesity is a negative predictor of remission of diabetes 1 year after bariatric surgery." 01/01/2021 - "The association between a GRS for abdominal obesity and the response to bariatric surgery may be dependent on the association between the GRS and baseline BMI." 01/01/2020 - "We recommend its use for the evaluation of central obesity, particularly for research issues and body imaging before and after bariatric surgery." 12/01/2019 - "The implementation of an exercise program prior to bariatric surgery reduces fat mass and central obesity and improves cardiometabolic risk factors and quality of life, especially in the physical scales. " 01/01/2017 - "Forty obese individuals who underwent bariatric surgery, divided in three groups based on the number of components of MetS, in addition to abdominal obesity (0, 1, and 2-3 additional components), were studied. "