|2.||Muscular Dystrophies (Muscular Dystrophy)
|3.||Atrophic Muscular Disorders
|5.||Body Weight (Weight, Body)
|1.||Leeuwenburgh, Christiaan: 14 articles (01/2013 - 01/2004)|
|2.||Landi, Francesco: 13 articles (12/2015 - 07/2008)|
|3.||Volpi, Elena: 11 articles (09/2015 - 07/2004)|
|4.||Dasarathy, Srinivasan: 11 articles (08/2015 - 05/2011)|
|5.||Bernabei, Roberto: 10 articles (12/2015 - 07/2008)|
|6.||Onder, Graziano: 10 articles (01/2015 - 07/2008)|
|7.||Ferrucci, Luigi: 9 articles (01/2016 - 08/2002)|
|8.||Marzetti, Emanuele: 9 articles (12/2015 - 12/2006)|
|9.||Dardevet, Dominique: 9 articles (05/2015 - 01/2003)|
|10.||Ohlendieck, Kay: 9 articles (02/2013 - 04/2003)|
|1.||Testosterone (Sustanon)FDA Link
11/01/2010 - "Testosterone increases lean mass and may help to counter the changes in muscle architecture associated with sarcopenia. "
02/01/2015 - "The purposes of this study were to provide population-based reference data on lean body mass (LBM) in young men during the time of peak levels of GH/IGF-1 and testosterone and further to apply the reference data on a population-based sample of men aged 60-74 years to estimate the prevalence of sarcopenia. "
01/01/2014 - "Translational studies in older men using testosterone to treat sarcopenia."
11/01/2006 - "Key words included testosterone, androgen, sarcopenia, muscle loss, aged, aging, elderly, older, geriatric, randomized controlled trials, and controlled clinical trials. "
11/01/2015 - "17β-Estradiol and testosterone in sarcopenia: Role of satellite cells."
10/01/2014 - "Myostatin inhibition: a new treatment for androgen deprivation-induced sarcopenia?"
08/01/2007 - "The present study specifically tests the therapeutic value of a myostatin antagonist in sarcopenia. "
12/01/2015 - "Higher serum myostatin independently associated with higher odds for sarcopenia in men (OR = 1.11, 95 % CI 1.00-1.24, p = 0.041). "
12/01/2015 - "Myostatin inhibition for treatment of sarcopenia."
08/01/2015 - "One of the genetic contributors to sarcopenia predisposition is Myostatin (MSTN), which in humans encodes myostatin, a 376 amino acid growth factor protein that negatively regulates muscle growth. "
|3.||Vitamin DFDA LinkGeneric
11/01/2008 - "He also introduces recent findings on the relationship between serum vitamin D concentration and falls or sarcopenia among the elderly, which well be one of the effective treatment for those frail conditions."
09/01/2015 - "Studies with superior methodological characteristics are needed in order to establish a role for vitamin D on the treatment of sarcopenia in postmenopausal women."
09/01/2015 - "To elucidate the role of vitamin D with respect to sarcopenia in postmenopausal women, providing current evidence from both molecular and clinical studies. "
11/01/2013 - "In a study of noninstitutionalized elderly subjects, we investigated the simultaneous effect of vitamin D and sarcopenia on bone mineral density (BMD) and found that sarcopenia was associated with low BMD in the femur, especially in those with suboptimal vitamin D levels. "
12/01/2015 - "Several molecular pathways may account for the development of muscle wasting in sarcopenia, and there is mounting epidemiological and laboratory evidence that supports a role of vitamin D on muscle cell proliferation and function. "
|4.||Biological Markers (Surrogate Marker)IBA
01/01/2008 - "The proteomic analysis of aged muscle has identified a large cohort of new biomarkers of sarcopenia including opposite changes in PK and AK, which might be useful for the design of improved diagnostic procedures and/or therapeutic strategies to counteract ageing-induced muscle degeneration."
07/01/2013 - "The Task Force reviewed results from previous trials in related disease areas to extract lessons relevant to future sarcopenia trials, including practical issues regarding the design and conduct of trials in elderly populations, the definition of appropriate target populations, and the selection of screening tools, outcome measures, and biomarkers. "
09/01/2012 - "Importantly, sarcopenia biomarkers will have to be tested and validated in clinical trials."
09/01/2012 - "In this regard, we need good biomarkers that can be quantified in a reliable, cost-effective manner and that guide diagnosis and therapy of pathological sarcopenia in routine clinical practice and clinical trials. "
09/01/2012 - "The meeting was specifically focused at gaining knowledge on the currently available biomarkers (functional, biological, or imaging-related) that could be utilized in clinical trials of sarcopenia and considered the most reliable and promising to evaluate age-related modifications of skeletal muscle. "
|5.||Leucine (L-Leucine)FDA Link
06/01/2011 - "Further studies are needed to establish, whether and to what extent the use of leucine-enriched whey products prevent or treat age-associated sarcopenia and whether they are superior to the present commercial milk products."
04/01/2012 - "Leucine acts as a signal nutrient in promoting protein synthesis in skeletal muscle and adipose tissue via mTOR pathway activation, and may be of interest in age-related sarcopenia. "
01/01/2012 - "Leucine has been proposed as a promising pharmaconutrient in the prevention and treatment of sarcopenia and/or type 2 diabetes. "
11/01/2011 - "Consequently, it has been suggested that leucine represents an effective pharmaconutrient for the prevention and treatment of sarcopenia and type 2 diabetes. "
11/01/2011 - "Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes."
|6.||Insulin-Like Growth Factor I (IGF-1)IBA
01/01/2005 - "However, few studies have documented a precise role of IGF-I in the development of sarcopenia, frailty and poor mobility. "
12/01/2015 - "Serum IGF-1 was significantly lower amongst female sarcopenic subjects, with demonstrable trend for protective effect against sarcopenia in multiple regression models, such that each 1 ng/ml increase in IGF-1 was associated with 1 % decline in odds of sarcopenia in women (p = 0.095). "
12/01/2014 - "We hypothesized that constitutively expressed IGF-1 within skeletal muscles with or without exercise would prevent sarcopenia. "
01/01/2013 - "To confirm these observations made on humans, we studied mice overexpressing muscle-specific IGF-1, which are protected from sarcopenia. "
08/01/2012 - "Although advanced age is associated with both a reduction in the GH/IGF-I axis activity, and in skeletal muscle mass (sarcopenia) as well as in tendon connective tissue, there is no direct proof linking age-related changes in the musculotendinous tissue to an impaired GH/IGF-I axis."
|7.||Proteins (Proteins, Gene)IBA
12/01/2006 - "Therefore, the synergistic effects of CR with maintained protein intake may help to limit the progression of sarcopenia by optimizing the turnover rates and functions of major proteins in skeletal muscle."
12/01/2010 - "The aim of this study was to determine the involvement of this proteolytic system in the phenotype associated with sarcopenia by identifying key proteins (substrates or regulators) interacting with calpains during muscle aging. "
02/01/2015 - "Abundance of cytoprotective proteins, including various HSPs (HSP 27 and 70), were unaffected by aging/sarcopenia. "
01/01/2015 - "Similarly, adherence to the Mixed dietary pattern, characterized by a high consumption of animal proteins, potatoes, and refined grains, did not affect the odds of sarcopenia (OR = 1.45; 95% CI = 0.66-3.19; P for trend = 0.95). "
11/07/2014 - "The molecular mechanisms underlying skeletal muscle aging and associated sarcopenia have been linked to an altered oxidative status of redox-sensitive proteins. "
|8.||Growth Hormone (Somatotropin)IBA
10/01/2014 - "The aim of our study was to elucidate the role of growth hormone (GH) replacement therapy in three of the main mechanisms involved in sarcopenia: alterations in mitochondrial biogenesis, increase in oxidative stress, and alterations in protein balance. "
10/01/2014 - "Growth hormone replacement therapy prevents sarcopenia by a dual mechanism: improvement of protein balance and of antioxidant defenses."
11/04/2008 - "The decline of growth hormone in the development of sarcopenia is one of many factors, and its etiologic role needs to be demonstrated. "
11/04/2008 - "Growth hormone secretion and muscle mass decline from midpuberty throughout life, culminating in sarcopenia, frailty, decreased function, and loss of independence. "
01/01/2000 - "There are many candidate mechanisms leading to sarcopenia, including age-related declines in alpha-motor neurons, growth hormone production, sex steroid levels, and physical activity. "
|9.||Amino AcidsFDA Link
05/01/2013 - "In terms of managing sarcopenia, many studies have shown that physical activity (in particular resistance exercise) and specific nutrition interventions such as protein and amino acids supplementation can improve muscle mass and strength in older adults. "
06/02/2008 - "The purpose of our study was to assess the effect of an orally administered special mixture of amino acids (AAs) in elderly subjects with reduced lean body mass and sarcopenia. "
11/01/2015 - "Since amino acids and energy are required for muscle synthesis it is possible that nutritional intake influences sarcopenia. "
01/01/2010 - "Dysfunction of mTOR signaling in the elderly and its potential role as a target of amino acids in the treatment of age-related sarcopenia will be discussed."
04/01/2005 - "Role of protein and amino acids in the pathophysiology and treatment of sarcopenia."
06/01/2015 - "The aim of this study was to investigate the relationship between plasma ghrelin levels and sarcopenia in elderly people. "
06/01/2015 - "This cross-sectional study does not allow a definitive conclusion about the relationship between ghrelin levels and sarcopenia. "
06/01/2015 - "Elderly subjects without sarcopenia had the same ghrelin levels as young adults (899.3 vs. 899.6 pg mL-1). "
06/01/2015 - "In the elderly group, subjects with sarcopenia showed significantly lower ghrelin levels than those without sarcopenia (650 vs. 899 pg mL-1, P = 0.036), but these differences disappeared when stratifying by gender. "
06/01/2015 - "Sarcopenia, diagnosed according to the EWGSOP definition, fasting and postprandial plasma ghrelin levels, body composition, hand grip, Barthel score, and frailty using Fried criteria. "
08/01/2006 - "Resistance training (RT) has shown the most promise in reducing/reversing effects of sarcopenia, although the optimum regime specific for older adults remains unclear. "
01/01/2014 - "Resistance training added to aerobic exercise or high-intensity interval training promote numerous changes in skeletal muscle, many of which may help to prevent or reverse sarcopenia. "
02/01/2014 - "Although progressive resistance training has been widely accepted as an appropriate modality for the treatment of sarcopenia, it has yet to offer consistent results in terms of improved balance. "
01/01/2008 - "Progressive resistance training (PRT) is widely accepted as an appropriate modality for treating sarcopenia and has been reported to improve balance. "
06/01/2000 - "Treatment of sarcopenia with progressive resistance training is safe and effective, but dissemination of this technique to the general population has yet to occur. "
09/01/2015 - "In addition, long-term caloric restriction (CR) and lifelong wheel running exercise (WR) with CR provide significant protection against caspase-dependent apoptosis and sarcopenia. "
12/01/2015 - "However, the effectiveness and safety of caloric restriction for sarcopenia remained unclear. "
01/01/2013 - "The two major strategies that counteract sarcopenia, that is, caloric restriction and endurance training, are well known to protect neuromuscular junction (NMJ) integrity, albeit through undefined mechanisms. "
12/01/2011 - "Caloric restriction has been shown to be beneficial as a sarcopenia and aging antagonist. "
01/01/2010 - "Combined interventions that may be required to reverse sarcopenia, such as exercise, caloric restriction, and nutrition, will also be discussed."
02/01/2012 - "We also propose the study of new extrapulmonary factors, such as frailty and sarcopenia, that might help improve the prediction of complications and early death after lung transplantation, leading to an improved candidate selection process."
12/01/2014 - "Further standardization of measurement techniques is needed to assess the clinical effect of sarcopenia in lung transplantation."
12/01/2014 - "Sarcopenia in lung transplantation: a systematic review."
|4.||Activities of Daily Living (ADL)
09/01/2015 - "The aim of the present study was to determine the association between muscular function using mechanography and sarcopenia, falls and impairment in the activities of daily living (ADL) in a sample of 293 community-dwelling women and men aged 60-85 years in Berlin, Germany. "
02/01/2015 - "[Purpose] The purpose of the current study was to clarify problems associated with swallowing, related to nutrition and activities of daily living (ADL), in elderly individuals with sarcopenia. "
10/01/2013 - "Among sarcopenia patients in the baseline study, 36.8% of men and 18.8% of women became dependent in ADL at 2-year follow up. "
07/01/2001 - "Geriatric medicine has recently focused on the biological mechanisms contributing to disability in the activities of daily living (ADLs), with special emphasis given to the study of sarcopenia, an age-related decline in muscle mass. "
12/01/2015 - "We assessed the association of physical limitations, basic and instrumental activities of daily living and sarcopenia status. "
06/01/2014 - "In this study, we aimed to establish whether sarcopenia predicts increased morbidity or mortality after liver transplantation. "
11/01/2013 - "There is a compelling need for studies to examine the mechanisms and consequences of sarcopenia post liver transplantation to permit development of therapies to prevent and reverse this disorder."
06/01/2013 - "The present study investigated the impact of sarcopenia on patients undergoing living donor liver transplantation (LDLT). "
10/21/2015 - "Sarcopenia is associated with morbidity and mortality before and after liver transplantation. "
03/01/2015 - "We conclude that after liver transplantation sarcopenia does not progress but is arrested and frequently improves in the absence of confounding conditions."