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Loeys-Dietz Syndrome

An autosomal dominant aneurysm with multisystem abnormalities caused by increased TGF-BETA signaling due to mutations in type I or II of TGF-BETA RECEPTOR. Additional craniofacial features include CLEFT PALATE; CRANIOSYNOSTOSIS; HYPERTELORISM; or bifid uvula. Phenotypes closely resemble MARFAN SYNDROME; Marfanoid craniosynostosis syndrome (Shprintzen-Goldberg syndrome); and EHLERS-DANLOS SYNDROME.
Also Known As:
Loeys Dietz Aortic Aneurysm Syndrome; Loeys Dietz Syndrome; Syndrome, Loeys-Dietz; Loeys-Dietz Aortic Aneurysm Syndrome
Networked: 89 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Related Diseases

1. Marfan Syndrome (Marfan's Syndrome)
2. Aortic Aneurysm (Aneurysm, Aortic)
3. Aneurysm (Aneurysms)
4. Funnel Chest (Pectus Excavatum)
5. Pain (Aches)

Experts

1. Dietz, Harry C: 11 articles (02/2015 - 04/2006)
2. Loeys, Bart L: 7 articles (06/2013 - 08/2006)
3. von Kodolitsch, Yskert: 5 articles (03/2015 - 07/2010)
4. Morisaki, Takayuki: 5 articles (06/2014 - 08/2007)
5. Robinson, Peter N: 4 articles (11/2014 - 07/2010)
6. Morisaki, Hiroko: 4 articles (11/2012 - 08/2007)
7. Braverman, Alan C: 3 articles (09/2015 - 08/2006)
8. Oswald, Gretchen: 3 articles (02/2015 - 08/2012)
9. Myers, Loretha: 3 articles (02/2015 - 08/2012)
10. Schepers, Dorien: 3 articles (02/2015 - 08/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Loeys-Dietz Syndrome:
1. Transforming Growth Factor beta (TGF-beta)IBA
2. 1,3,4,6- tetra- O- acetyl- 2- azido- 2- deoxyglucopyranoseIBA
3. Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA
4. Transforming Growth Factors (Transforming Growth Factor)IBA
5. Transforming Growth Factor beta3 (TGF beta 3)IBA
6. Neuraminidase deficiency with beta-galactosidase deficiencyIBA
7. glucuronyl glucosamine glycan sulfate (Vessel)IBA
8. fibrillinIBA
9. CollagenIBA
10. MASS syndromeIBA

Therapies and Procedures

1. Electrodes (Electrode)
2. Transplants (Transplant)
3. Angioplasty (Angioplasty, Transluminal)
4. Anesthesia
5. Catheters