SOX9 Transcription Factor

A SOXE transcription factor that plays a critical role in regulating CHONDROGENESIS; OSTEOGENESIS; and male sex determination. Loss of function of the SOX9 transcription factor due to genetic mutations is a cause of CAMPOMELIC DYSPLASIA.

Also Known As:

Networked: 73 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Brown, Arthur: 2 articles (01/2018 - 01/2016)
2.	Hryciw, Todd: 2 articles (01/2018 - 01/2016)
3.	Liu, Tony: 2 articles (01/2018 - 01/2016)
4.	McKillop, William M: 2 articles (01/2018 - 01/2016)
5.	Hao, Ping: 2 articles (01/2017 - 01/2017)
6.	Qi, Jin: 2 articles (01/2017 - 01/2017)
7.	Xu, Jianqiang: 2 articles (01/2017 - 01/2017)
8.	Yang, Yaoqi: 2 articles (01/2017 - 01/2017)
9.	Bruns, Christiane J: 2 articles (02/2015 - 03/2014)
10.	Camaj, Peter: 2 articles (02/2015 - 03/2014)

Related Diseases

1.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2018 - "We previously identified the transcription factor SOX9 as a key up-regulator of CSPG production and demonstrated that conditional Sox9 ablation leads to increased axonal sprouting and improved recovery after spinal cord injury. " 01/01/2016 - "The absence of axonal regeneration after spinal cord injury (SCI) has been attributed to the up-regulation of axon-repelling molecules, such as chondroitin sulfate proteoglycans (CSPGs) present in the glial scar that forms post-SCI. We previously identified the transcription factor SOX9 as a key up-regulator of CSPG production and also demonstrated that conditional Sox9 ablation leads to decreased CSPG levels and improved recovery of hind limb function after SCI. We herein demonstrate increased neural input onto spinal neurons caudal to the lesion in spinal cord injured Sox9 conditional knock out mice as indicated by increased levels of the presynaptic markers synaptophysin and vesicular glutamate transporter 1 (VGLUT1) compared to controls. "
2.	Gliosis 01/01/2016 - "The absence of axonal regeneration after spinal cord injury (SCI) has been attributed to the up-regulation of axon-repelling molecules, such as chondroitin sulfate proteoglycans (CSPGs) present in the glial scar that forms post-SCI. We previously identified the transcription factor SOX9 as a key up-regulator of CSPG production and also demonstrated that conditional Sox9 ablation leads to decreased CSPG levels and improved recovery of hind limb function after SCI. We herein demonstrate increased neural input onto spinal neurons caudal to the lesion in spinal cord injured Sox9 conditional knock out mice as indicated by increased levels of the presynaptic markers synaptophysin and vesicular glutamate transporter 1 (VGLUT1) compared to controls. "
3.	Neoplasms (Cancer) 11/01/2023 - "To overcome these difficulties, this study investigated the transcription factor SOX9 expression, morphology, and genetics of skin adnexal tumors for understanding their biology, especially their histogenesis. " 06/01/2023 - "The SOX9 transcription factor ensures proper tissue development and homeostasis and has been implicated in promoting tumor progression. " 11/01/2020 - "The transcription factor SOX9 is frequently amplified in diverse advanced-stage human tumors. " 04/01/2009 - "Recent evidence indicates that the antiproliferative effects of RA are mediated by the transcription factor SOX9 in human cancer cell lines. " 04/01/2004 - "Two cases of ovarian Sertoli-stromal cell tumor were examined for expression of a transcription factor, SOX9, which plays an essential role in Sertoli cell differentiation, downstream of Sry, as in the testis. "
4.	Carcinogenesis 01/01/2015 - "The transcription factor SOX9 plays a crucial role in normal prostate development and has been suggested to drive prostate carcinogenesis in concert with PTEN inactivation. " 06/01/2012 - "In this study, we used conditional gene targeting and organ grafting, to describe conserved roles for the transcription factor Sox9 in the initiation of both prostate organogenesis and prostate carcinogenesis in murine models. " 04/01/2021 - "CAP2 contributes to tumorigenesis in gastric cancer by targeting transcription factor SOX9." 12/04/2008 - "Among the genes with the most significant links to the development and cancer, we highlight coordinate induction of the transcription factor Sox9 and suppression of the proapoptotic phospholipid-binding protein Annexin A1 that link early prostate development to early prostate carcinogenesis. "
5.	Stomach Neoplasms (Stomach Cancer) 01/01/2018 - "Aim of this study was to investigate the prognostic value of ECG and its association with a stem cell like phenotype indicated by expression of the transcription factor SOX9 in gastric cancer. " 01/01/2019 - "Here, we sought to ascertain the relevance of SOX9 transcription factor as a prognostic marker in gastric cancer. " 04/01/2021 - "CAP2 contributes to tumorigenesis in gastric cancer by targeting transcription factor SOX9."

Related Drugs and Biologics

1.	Vesicular Glutamate Transport Protein 1
2.	Synaptophysin
3.	Chondroitin Sulfate Proteoglycans
4.	Long Noncoding RNA
5.	CEACAM1 Protein
6.	Proteins (Proteins, Gene)
7.	Collagen
8.	Type 1 Parathyroid Hormone Receptor (Parathyroid Hormone Receptor)
9.	Messenger RNA (mRNA)
10.	claudin 8

Related Therapies and Procedures

1.	Organ Transplantation
2.	Therapeutics