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Primary Myelofibrosis (Myelosclerosis)

A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
Also Known As:
Myelosclerosis; Agnogenic Myeloid Metaplasia; Bone Marrow Fibrosis; Fibrosis, Bone Marrow; Myelofibrosis; Myeloid Metaplasia; Myelosis, Nonleukemic; Agnogenic Myeloid Metaplasias; Bone Marrow Fibroses; Fibroses, Bone Marrow; Metaplasia, Agnogenic Myeloid; Metaplasia, Myeloid; Metaplasias, Agnogenic Myeloid; Metaplasias, Myeloid; Myelofibroses; Myelofibroses, Primary; Myelofibrosis, Primary; Myeloid Metaplasia, Agnogenic; Myeloid Metaplasias; Myeloid Metaplasias, Agnogenic; Myeloscleroses; Myeloses, Nonleukemic; Nonleukemic Myeloses; Nonleukemic Myelosis; Primary Myelofibroses
Networked: 1995 relevant articles (147 outcomes, 213 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Primary Myelofibrosis (Myelosclerosis)
2. Splenomegaly
3. Anemia
4. Thrombocytosis (Thrombocythemia)
5. Myelodysplastic Syndromes (Myelodysplastic Syndrome)

Experts

1. Verstovsek, Srdan: 80 articles (11/2015 - 05/2006)
2. Tefferi, Ayalew: 79 articles (12/2015 - 03/2002)
3. Mesa, Ruben A: 58 articles (11/2015 - 03/2002)
4. Barosi, Giovanni: 43 articles (12/2015 - 12/2002)
5. Vannucchi, Alessandro M: 40 articles (11/2015 - 06/2004)
6. Tefferi, A: 32 articles (11/2015 - 01/2000)
7. Hoffman, Ronald: 31 articles (09/2015 - 05/2005)
8. Kröger, Nicolaus: 27 articles (12/2015 - 12/2002)
9. Cervantes, Francisco: 26 articles (11/2015 - 11/2004)
10. Pardanani, Animesh: 26 articles (09/2015 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Primary Myelofibrosis:
1. INCB018424IBA
2. Thalidomide (Thalomid)FDA Link
3. lenalidomide (CC 5013)FDA Link
4. imatinib (Gleevec)FDA Link
5. Phosphotransferases (Kinase)IBA
6. Prednisone (Sone)FDA LinkGeneric
7. InterferonsIBA
8. Hydroxyurea (Hydrea)FDA LinkGeneric
9. IronIBA
10. Cytarabine (Cytosar-U)FDA LinkGeneric

Therapies and Procedures

1. Transplants (Transplant)
2. Stem Cell Transplantation
3. Drug Therapy (Chemotherapy)
4. Bone Marrow Transplantation (Transplantation, Bone Marrow)
5. Transplantation (Transplant Recipients)